Nanoparticle fabrication methods, systems, and materials for fabricating artificial red blood cells
A plurality of artificial red blood cell particles includes each particle of the plurality being substantially monodisperse and each particle having a largest common linear dimension of about 5 μm to about 10 μm. The particles can also have a modulus configured such that a particle of the plurality of particles can pass through a tube having an inner diameter of less than about 3 μm.
1. A synthetic particle, comprising:
a molded synthetic polymer particle having:
a largest linear dimension of between about 5 μm to about 10 μm; and,
a modulus of less than about 1 MPa, wherein the particle can pass through an opening of less than about 3 μm.
2. The particle of claim 1 , wherein the synthetic polymer comprises a biocompatible polymer.
3. The particle of claim 1 , wherein the synthetic polymer comprises poly(ethylene glycol) or poly(ethylene glycol) diacrylate.
4. The particle of claim 1 , wherein the particle further comprises a cargo selected from the group consisting of a therapeutic agent, a biologic, a diagnostic agent, hemoglobin, and an imaging agent.
5. The particle of claim 1 , wherein the opening is an orifice or an opening of a tube or a lumen.
6. The particle of claim 1 , wherein the particle further comprises an engineered shape characteristic comprising an arc or vertex imparted on the particle by the mold.
7. A drug delivery particle, comprising:
a molded synthetic polymer particle comprising a cargo and having:
a largest linear dimension less than about 10 μm; and,
a modulus of less than about 1 MPa, wherein the particle can pass through an opening of less than about 60% the largest linear dimension of the particle.
8. The drug delivery particle of claim 7 , wherein the particle can pass through an opening of less than about 37.5% the largest linear dimension of the particle.
9. The drug delivery particle of claim 7 , wherein the particle can pass through an opening of less than about 30% the largest linear dimension of the particle.
10. The drug delivery particle of claim 7 , wherein the synthetic polymer comprises a biocompatible polymer.
11. The drug delivery particle of claim 7 , wherein the synthetic polymer comprises poly(ethylene glycol) or poly(ethylene glycol) diacrylate.
12. The drug delivery particle of claim 7 , wherein the cargo is selected from the group consisting of a therapeutic agent, a biologic, a diagnostic agent, hemoglobin, and an imaging agent.
13. The drug delivery particle of claim 7 , wherein the opening is an orifice or an opening of a tube or a lumen.
14. The drug delivery particle of claim 7 , wherein the particle further comprises an engineered shape characteristic comprising an arc or vertex imparted on the particle by the mold.
15. A polymeric medical device, comprising:
a molded polymer having:
a largest linear dimension less than about 10 μm; and,
a modulus of less than about 1 MPa, wherein the device can pass through an opening less than about 60% the largest linear dimension of the device.
16. The polymeric medical device of claim 15 , wherein the device can pass through an opening of less than about 37.5% the largest linear dimension of the device.
17. The polymeric medical device of claim 15 , wherein the synthetic polymer comprises poly(ethylene glycol) or poly(ethylene glycol) diacrylate.
18. The polymeric medical device of claim 15 , wherein the device further comprises a cargo selected from the group consisting of a therapeutic agent, a biologic, a diagnostic agent, hemoglobin, and an imaging agent.
19. The polymeric medical device of claim 15 , wherein the opening is an orifice or an opening of a tube or a lumen.