Allergen dosage form
The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided. Suitable matrices are gelatine, starch and mannitol. Methods for the dosage forms are also provided.
1. A method for reducing house dust mite-induced allergic symptoms in a patient, said method comprising:
sublingually administering to a patient having at least one clinical allergy symptom of house dust mite-induced allergy a sublingual dosage form containing an effective dose of house dust mite allergen, and
repeatedly administering a sublingual dosage form comprising said effective dose of house dust mite allergen daily to said patient, wherein the method does not comprise an up-dosing phase, wherein the repeated administration of said sublingual dosage forms reduces the at least one clinical allergy symptom, and wherein said allergen is a Dermatophagoides house dust mite allergen.
2. The method of claim 1 , wherein said sublingual dosage form is a tablet.
3. The method of claim 2 , wherein said sublingual tablet is packaged in a multiple tablet blister pack comprising multiple tablets.
4. The method of claim 2 , wherein the sublingual administration comprises placing the tablet under the tongue for at least 1 minute before swallowing.
5. The method of claim 1 , wherein the Dermatophagoides house dust mite allergen comprises Der f 1, Der f 2, Der p 1, and Der p 2.
6. The method of claim 1 , wherein the at least one clinical allergy symptom is reduced in severity or relieved.
7. The method of claim 1 , wherein the at least one clinical allergy symptom is allergic rhinitis.
8. The method of claim 1 , wherein the at least one clinical allergy symptom is asthma.
9. The method of claim 1 , wherein the Dermatophagoides house dust mite allergen is comprised within an extract.
10. The method of claim 9 , wherein the Dermatophagoides house dust mite extract is a freeze-dried extract.
11. The method of claim 9 , wherein the Dermatophagoides house dust mite allergen extract comprises the allergens Der f 1, Der f 2, Der p 1, and Der p 2.
12. A method for treating house dust mite-induced allergy in a patient said method comprising:
sublingually administering to a patient having house dust mite-induced allergy a sublingual dosage form containing an effective dose of house dust mite allergen, and
repeatedly administering a sublingual dosage form comprising said effective dose of house dust mite allergen daily to said patient, wherein the method does not comprise an up-dosing phase, wherein the repeated administration of said sublingual dosage form treats the house dust mite-induced allergy, and wherein said allergen is a Dermatophagoides house dust mite allergen.
13. The method of claim 12 , wherein said sublingual dosage form is a tablet.
14. The method of claim 13 , wherein said sublingual tablet is packaged in a multiple tablet blister pack comprising multiple tablets.
15. The method of claim 13 , wherein the sublingual administration comprises placing the tablet under the tongue for at least 1 minute before swallowing.
16. The method of claim 12 , wherein the Dermatophagoides house dust mite allergen comprises Der f 1, Der f 2, Der p 1, and Der p 2.
17. The method of claim 12 , wherein the house dust mite-induced allergy is reduced in severity or relieved.
18. The method of claim 12 , wherein the house dust mite-induced allergy is allergic rhinitis.
19. The method of claim 12 , wherein the house dust mite-induced allergy is asthma.
20. The method of claim 12 , wherein the Dermatophagoides house dust mite allergen is comprised within an extract.
21. The method of claim 20 , wherein the Dermatophagoides house dust mite extract is a freeze-dried extract.
22. The method of claim 20 , wherein the Dermatophagoides house dust mite allergen extract comprises the allergens Der f 1, Der f 2, Der p 1, and Der p 2.
23. The method of claim 12 , wherein said sublingual dosage form comprises an allergen extract comprising said effective dose of house dust mite allergen.