Systems and methods for treating acute and chronic heart failure
Systems and methods and devices are provided for arresting or reversing the effects of myocardial remodeling and degeneration after cardiac injury, without the potential drawbacks associated with previously existing systems and methods, by at least partially occluding flow through the superior vena cava over multiple cardiac cycles, and more preferably, by adjusting the interval or degree of occlusion responsive to a sensed level of patient activity. In some embodiments, a controller is provided that actuates a drive mechanism responsive to a sensed level of patient activity to provide at least partial occlusion of the patient's superior vena cava, while a data transfer circuit of the controller provides bi-directional transfer of physiologic data to the patient's smartphone or tablet to permit display and review of such data.
1. A method for treating heart failure in a patient, the method comprising:
inserting and guiding to a superior vena cava of a patient a catheter having a proximal end, a distal region, and a flow limiting element disposed at the distal region of the catheter;
intermittently actuating the flow limiting element responsive to instructions programmed in a controller to expand the flow limiting element to maintain at least partial occlusion of only the superior vena cava for a predetermined interval over multiple cardiac cycles followed by contraction of the flow limiting element;
sensing a physiologic parameter indicative of the patient's hemodynamic state;
generating an output signal corresponding to the sensed physiologic parameter indicative of the patient's hemodynamic state; and
adjusting the actuation of the flow limiting element responsive to the output signal corresponding to the sensed physiologic parameter indicative of the patient's hemodynamic state.
2. The method of claim 1 , further comprising, after adjusting the predetermined interval of actuation, actuating the flow limiting element only once at the predetermined interval.
3. The method of claim 1 , wherein adjusting the actuation of the flow limiting element further comprises adjusting the predetermined interval of actuation responsive to the output signal corresponding to the sensed physiologic parameter.
4. The method of claim 3 , further comprising adjusting the predetermined interval of actuation to comprise a specified time interval.
5. The method of claim 1 , wherein intermittently actuating the flow limiting element responsive to instructions programmed in the controller further comprises actuating the flow limiting element to a predetermined degree of expansion.
6. The method of claim 5 , wherein adjusting the actuation of the flow limiting element further comprises adjusting the predetermined degree of expansion of the flow limiting element responsive to the output signal corresponding to the sensed physiologic parameter indicative of the patient's hemodynamic state.
7. The method of claim 1 , wherein intermittently actuating the flow limiting element further comprises actuating the flow limiting element to impede blood flow in the superior vena cava by at least 50%.
8. The method of claim 1 , wherein sensing a physiologic parameter indicative of the patient's hemodynamic state comprises sensing one or more of blood flow rate, blood volume, pressure including cardiac filling pressure, or central venous pressure.
9. A method for treating heart failure in a patient, the method comprising:
inserting and guiding to a superior vena cava of a patient a catheter haying a proximal end, a distal region, and a flow limiting element disposed at the distal region of the catheter;
programming a controller operatively coupled to the catheter to intermittently actuate the flow limiting element at a predetermined interval to expand the flow limiting element to maintain at least partial occlusion of only the superior vena cava over multiple cardiac cycles followed by contraction of the flow limiting element;
actuating the flow limiting element according to the predetermined interval;
sensing a physiologic parameter indicative of the patient's hemodynamic state;
generating an output signal corresponding to the sensed physiologic parameter indicative of the patient's hemodynamic state; and
adjusting the predetermined interval of actuation responsive to the output signal corresponding to the sensed physiologic parameter indicative of the patient's hemodynamic state.
10. The method of claim 9 , further comprising programming the controller operatively coupled to the catheter to actuate the flow limiting element to a predetermined degree of expansion.
11. The method of claim 10 , further comprising adjusting the predetermined degree of expansion responsive to the output signal corresponding'to the sensed physiologic parameter indicative of the patient's hemodynamic state.
12. The method of claim 11 , wherein adjusting the predetermined degree of expansion responsive to the output signal farther comprises actuating the flow limiting element to impede blood flow in the superior vena cava by at least 50%.
13. The method of claim 9 , further comprising receiving at a data transfer circuit the output signal corresponding to the sensed physiologic parameter and transmitting the output signal to the controller.
14. The method of claim 13 , wherein receiving at the data transfer circuit further comprises wirelessly transmitting the output signal from a sensor to the data transfer circuit.
15. The method of claim 13 , further comprising transmitting the output signal corresponding to the sensed physiological parameter to a computing device of the patient.