Intravascular treatment catheters
The present invention provides devices and methods for decalcifying an aortic valve. The methods and devices of the present invention break up or obliterate calcific deposits in and around the aortic valve through application or removal of heat energy from the calcific deposits.
1. An apparatus, comprising:
a catheter configured for intravascular placement within a body lumen of a human patient,
wherein the catheter comprises an expandable distal basket formed from a plurality of elongate members;
wherein the distal basket is transformable between—
a low-profile delivery configuration, and
an expanded deployed configuration wherein one or more of the elongate members of the distal basket contact a wall of the body lumen and are arranged such that blood is allowed to flow therethrough; and
a plurality of electrodes arranged along the elongate members of the basket and adapted to be positioned into contact with the wall of the body lumen when the basket is in the deployed configuration, wherein at least two of the electrodes are at different longitudinal positions along the basket, and wherein the electrodes are configured to deliver an electric field to target tissue adjacent the body lumen,
wherein the distal basket comprises a plurality of infusion ports or outlets distributed along each of the elongate members of the basket and configured to allow infusion of a pharmaceutical agent into the body lumen, and wherein the plurality of infusion ports or outlets are interspersed among and distinct from the plurality of electrodes arranged along the elongate members of the basket.
2. The apparatus of claim 1 wherein the elongate members of the distal basket are fabricated from shape-memory material.
3. The apparatus of claim 1 wherein the elongate members of the distal basket are composed, at least in part, of a metal material.
4. The apparatus of claim 1 wherein the elongate members of the distal basket are composed, at least in part, of plastic.
5. The apparatus of claim 1 wherein the basket is collapsible for delivery to the body lumen within a guide catheter, and further wherein the basket is configured to self-expand into contact with the wall of the body lumen upon removal from the guide catheter.
6. The apparatus of claim 1 wherein the basket is collapsible for delivery to the body lumen within a guide catheter, and further wherein the basket is configured to be mechanically actuated to transform the basket from the low-profile delivery configuration into the expanded deployed configuration.
7. The apparatus of claim 1 wherein the electrodes are arranged in a staggered configuration along the members of the basket, and wherein the electrodes are configured to be energized to produce a plurality of treatment areas along the wall of the body lumen.
8. The apparatus of claim 1 wherein the electric field delivered by the electrodes comprises a non-pulsed thermal RF electric field.
9. The apparatus of claim 1 wherein the electric field delivered by the electrodes comprises a pulsed electric field.
10. The apparatus of claim 1 wherein a plurality of electrodes are carried by each elongate member of the basket.
11. The apparatus of claim 1 wherein the infusion ports or outlets are configured to allow infusion of the pharmaceutical agent before, during, and/or after delivery of electrical energy to the target tissue.