IP Library › Granted Patent US 12,239,365
Granted Patent B2
US 12,239,365 · App. 17/529,037 · Granted Mar 4, 2025

Electroporation for obesity or diabetes treatment

Inventors: Christopher V. Desimone (Rochester, MN); Barham K. Abu Dayyeh (Rochester, MN); Samuel J. Asirvatham (Rochester, MN)
Assignee: Mayo Foundation for Medical Education and Research
A61B18/1492A61B1/00082A61B1/00151A61B90/361A61N1/327A61N1/36007A61B2018/00065A61B2018/00083A61B2018/0016A61B2018/0022A61B2018/00238A61B2018/00261A61B2018/00285A61B2018/00494A61B2018/00577A61B2018/00613A61B2018/00839A61B2018/00982A61B2018/126A61B2018/1467A61B2018/1472A61B2090/3966A61B2218/002A61M2025/1004A61M25/1011A61M2025/1015A61M25/10181A61M2025/105A61M2025/1052A61M2025/1079
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,239,365
App. No.
17/529,037
Granted
Mar 4, 2025
Kind
B2
Abstract

Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.

Claims (27)

1. A method of treating diabetes in a patient, comprising:

advancing an electroporation device comprising one or more electrodes into a duodenum of the patient; and

delivering electroporation energy to mucosa of the duodenum using the one or more electrodes to treat diabetes, wherein the electroporation energy is delivered to crypts of the mucosa of the duodenum.

2. The method of claim 1 further comprising transitioning the electroporation device from a first configuration to a second configuration.

3. The method of claim 2 , wherein the first configuration is a contracted configuration and the second configuration is an expanded configuration.

4. The method of claim 2 , wherein transitioning the electroporation device to the second configuration stretches at least a portion of the duodenum.

5. The method of claim 1 , wherein the electroporation energy comprises pulse currents.

6. The method of claim 1 , wherein the one or more electrodes comprise bipolar electrodes.

7. The method of claim 1 , wherein the one or more electrodes comprise a plurality of spaced-apart electrodes.

8. The method of claim 1 , wherein the electroporation device comprises a rolled-up member comprising the one or more electrodes.

9. The method of claim 8 , wherein the one or more electrodes are disposed on an outer surface of the rolled-up member.

10. The method of claim 8 , wherein the rolled-up member defines one or more apertures.

11. The method of claim 8 further comprising delivering a fluid into an interior space of the duodenum through the one or more apertures.

12. The method of claim 11 , wherein the fluid is circulated in the interior space of the duodenum while delivering the electroporation energy.

13. The method of claim 11 , wherein at least a portion of the rolled-up member is spaced apart from an inner wall of the duodenum, and wherein the fluid conducts at least some of the electroporation energy to the inner wall of the duodenum.

14. The method of claim 11 , wherein the fluid comprises a hydrogel.

15. The method of claim 11 , wherein the fluid comprises an electrically conductive liquid.

16. The method of claim 11 , wherein the fluid comprises a drug.

17. The method of claim 16 , wherein delivering the fluid comprises pheresing the drug to cells within the mucosa of the duodenum.

18. The method of claim 8 , wherein the rolled-up member defines a lumen and the method further comprises advancing an endoscope through the lumen of the rolled-up member.

19. The method of claim 1 further comprising measuring one or more characteristics of the delivered electroporation energy.

20. The method of claim 1 , wherein the electroporation energy treats the entirety of a circumferential portion of the duodenum.

21. The method of claim 1 , wherein delivering electroporation energy comprises delivering irreversible electroporation energy.

22. The method of claim 1 , wherein the electroporation energy resets diseased mucosa of the duodenum.

23. The method of claim 1 , wherein the electroporation energy increases a level of a gut hormone important in appetite regulation.

24. The method of claim 1 , wherein the electroporation energy increases a level of a gut hormone important in insulin secretion.

25. The method of claim 1 , wherein the electroporation energy reshapes the mucosa of the duodenum.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 27, 2022
From: DESIMONE, CHRISTOPHER V.; ABU DAYYEH, BARHAM K.; ASIRVATHAM, SAMUEL J.
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 061567/0865 →
Continuity (3)
Continuation 15766604
Provisional Application 62238191 · Oct 7, 2015
Related Publication 20220071700A1 · Mar 10, 2022
References Cited (400)
US 1953819A · Payne · 1934 [cited by applicant]
US 3245408A · Gonser · 1966 [cited by applicant]
US 4325374A · Komiya · 1982 [cited by examiner]
US 4676228A · Krasner et al. · 1987 [cited by applicant]
US 4969885A · Farin · 1990 [cited by applicant]
US 4979948A · Geddes · 1990 [cited by examiner]
US 5019034A · Weaver et al. · 1991 [cited by applicant]
US 5084044A · Quint · 1992 [cited by applicant]
US 5117828A · Metzger et al. · 1992 [cited by applicant]
US 5122137A · Lennox · 1992 [cited by applicant]
US 5137817A · Busta et al. · 1992 [cited by applicant]
US 5190540A · Lee · 1993 [cited by applicant]
US 5282785A · Shapland et al. · 1994 [cited by applicant]
US 5286254A · Shapland et al. · 1994 [cited by applicant]
US 5383917A · Desai et al. · 1995 [cited by applicant]
US 5419763A · Hildebrand · 1995 [cited by applicant]
US 5427118A · Nita et al. · 1995 [cited by applicant]
US 5464386A · Hofmann · 1995 [cited by applicant]
US 5498238A · Shapland et al. · 1996 [cited by applicant]
US 5505700A · Leone et al. · 1996 [cited by applicant]
US 5507724A · Hofmann et al. · 1996 [cited by applicant]
US 5515100A · Nogo · 1996 [cited by applicant]
US 5549603A · Feiring · 1996 [cited by applicant]
US 5575772A · Lennox · 1996 [cited by applicant]
US 5674267A · Mir et al. · 1997 [cited by applicant]
US 5697281A · Eggers et al. · 1997 [cited by applicant]
US 5702359A · Hofmann et al. · 1997 [cited by applicant]
US 5704908A · Hofmann et al. · 1998 [cited by applicant]
US 5800484A · Gough et al. · 1998 [cited by applicant]
US 5807306A · Shapland et al. · 1998 [cited by applicant]
US 5810762A · Hofmann · 1998 [cited by applicant]
US 5879349A · Edwards · 1999 [cited by applicant]
US 5944710A · Dev et al. · 1999 [cited by applicant]
US 5964753A · Edwards · 1999 [cited by applicant]
US 5968012A · Ren et al. · 1999 [cited by applicant]
US 6027488A · Hofmann et al. · 2000 [cited by applicant]
US 6045532A · Eggers et al. · 2000 [cited by applicant]
US 6053937A · Edwards et al. · 2000 [cited by applicant]
US 6055453A · Hofmann et al. · 2000 [cited by applicant]
US 6056744A · Edwards · 2000 [cited by applicant]
US 6068650A · Hofmann et al. · 2000 [cited by applicant]
US 6086581A · Reynolds et al. · 2000 [cited by applicant]
US 6112123A · Kelleher et al. · 2000 [cited by applicant]
US 6120493A · Hofmann · 2000 [cited by applicant]
US 6162237A · Chan · 2000 [cited by applicant]
US 6216034B1 · Hofmann et al. · 2001 [cited by applicant]
US 6219577B1 · Brown, II et al. · 2001 [cited by applicant]
US 6233482B1 · Hofmann et al. · 2001 [cited by applicant]
US 6241701B1 · Hofmann · 2001 [cited by applicant]
US 6325777B1 · Zadno-Azizi et al. · 2001 [cited by applicant]
US 6326177B1 · Schoenbach et al. · 2001 [cited by applicant]
US 6389314B2 · Feiring · 2002 [cited by applicant]
US 6428538B1 · Blewett et al. · 2002 [cited by applicant]
US 6516223B2 · Hofmann · 2003 [cited by applicant]
US 6529778B2 · Prutchi · 2003 [cited by applicant]
US 6542778B1 · Fuhr et al. · 2003 [cited by applicant]
US 6582423B1 · Thapliyal et al. · 2003 [cited by applicant]
US 6675809B2 · Stack et al. · 2004 [cited by applicant]
US 6678558B1 · Dimmer et al. · 2004 [cited by applicant]
US 6697669B2 · Dev et al. · 2004 [cited by applicant]
US 6697670B2 · Chomenky et al. · 2004 [cited by applicant]
US 6714861B2 · Okude et al. · 2004 [cited by applicant]
US 6758846B2 · Goble et al. · 2004 [cited by applicant]
US 6795728B2 · Chornenky et al. · 2004 [cited by applicant]
US 6905496B1 · Ellman et al. · 2005 [cited by applicant]
US 6936024B1 · Houser · 2005 [cited by applicant]
US 6978172B2 · Mori et al. · 2005 [cited by applicant]
US 6994706B2 · Chornenky et al. · 2006 [cited by applicant]
US 7004941B2 · Tvinnereim et al. · 2006 [cited by applicant]
US 7054685B2 · Dimmer et al. · 2006 [cited by applicant]
US 7150745B2 · Stern et al. · 2006 [cited by applicant]
US 7175669B2 · Geitz · 2007 [cited by applicant]
US 7220284B2 · Kagan et al. · 2007 [cited by applicant]
US 7272050B2 · Han et al. · 2007 [cited by applicant]
US 7285117B2 · Krueger et al. · 2007 [cited by applicant]
US 7326207B2 · Edwards · 2008 [cited by examiner]
US 7412284B2 · Hofmann · 2008 [cited by applicant]
US 7422587B2 · Bek et al. · 2008 [cited by applicant]
US 7458378B2 · Utley et al. · 2008 [cited by applicant]
US 7571729B2 · Saadat et al. · 2009 [cited by applicant]
US 7620451B2 · Demarais et al. · 2009 [cited by applicant]
US 7737109B2 · Miller · 2010 [cited by applicant]
US 7742795B2 · Stone et al. · 2010 [cited by applicant]
US 7758623B2 · Dzeng et al. · 2010 [cited by applicant]
US 7904172B2 · Kon et al. · 2011 [cited by applicant]
US 7909755B2 · Itoi · 2011 [cited by applicant]
US 7959627B2 · Utley et al. · 2011 [cited by applicant]
US 8032207B2 · Lapanashvili et al. · 2011 [cited by applicant]
US 8048067B2 · Davalos et al. · 2011 [cited by applicant]
US 8221411B2 · Francischelli et al. · 2012 [cited by applicant]
US 8251986B2 · Chornenky et al. · 2012 [cited by applicant]
US 8267932B2 · Baxter et al. · 2012 [cited by applicant]
US 8282631B2 · Davalos et al. · 2012 [cited by applicant]
US 8323229B2 · Shin et al. · 2012 [cited by applicant]
US 8355799B2 · Marion et al. · 2013 [cited by applicant]
US 8361066B2 · Long et al. · 2013 [cited by applicant]
US 8428735B2 · Littlewood et al. · 2013 [cited by applicant]
US 8473051B1 · Wessels et al. · 2013 [cited by applicant]
US 8529612B2 · Singh · 2013 [cited by applicant]
US 8562588B2 · Hobbs et al. · 2013 [cited by applicant]
US 8636648B2 · Gazdzinski · 2014 [cited by applicant]
US 8647338B2 · Chornenky et al. · 2014 [cited by applicant]
US 8740894B2 · Edwards · 2014 [cited by applicant]
US 8790339B2 · Edwards et al. · 2014 [cited by applicant]
US 8814860B2 · Davalos et al. · 2014 [cited by applicant]
US 8915911B2 · Azure · 2014 [cited by applicant]
US 8926576B2 · Mikkaichi · 2015 [cited by applicant]
US 8926606B2 · Davalos et al. · 2015 [cited by applicant]
US 9005100B2 · Gnanashanmugam et al. · 2015 [cited by applicant]
US 9005189B2 · Davalos et al. · 2015 [cited by applicant]
US 9011431B2 · Long et al. · 2015 [cited by applicant]
US 9078665B2 · Moss et al. · 2015 [cited by applicant]
US 9119600B2 · Richardson et al. · 2015 [cited by applicant]
US 9168096B2 · Kreindel · 2015 [cited by applicant]
US 9173704B2 · Hobbs et al. · 2015 [cited by applicant]
US 9179970B2 · Utley et al. · 2015 [cited by applicant]
US 9191801B2 · Kwak · 2015 [cited by applicant]
US 9198733B2 · Neal, II et al. · 2015 [cited by applicant]
US 9277957B2 · Long et al. · 2016 [cited by applicant]
US 9283051B2 · Garcia et al. · 2016 [cited by applicant]
US 9289606B2 · Paul et al. · 2016 [cited by applicant]
US 9308043B2 · Zarins et al. · 2016 [cited by applicant]
US 9314620B2 · Long et al. · 2016 [cited by applicant]
US 9345538B2 · Deem et al. · 2016 [cited by applicant]
US 9351789B2 · Novichenok et al. · 2016 [cited by applicant]
US 9351790B2 · Zemel et al. · 2016 [cited by applicant]
US 9358020B2 · Smith · 2016 [cited by applicant]
US 9462960B2 · Kassab · 2016 [cited by applicant]
US 9480524B2 · Chorenky et al. · 2016 [cited by applicant]
US 9555020B2 · Pasricha et al. · 2017 [cited by applicant]
US 9597147B2 · Jackson et al. · 2017 [cited by applicant]
US 9598691B2 · Davalos · 2017 [cited by applicant]
US 9737360B2 · West et al. · 2017 [cited by applicant]
US 9788885B2 · Long et al. · 2017 [cited by applicant]
US 9801681B2 · Laske et al. · 2017 [cited by applicant]
US 9827041B2 · Zarins et al. · 2017 [cited by applicant]
US 9861435B2 · Richardson et al. · 2018 [cited by applicant]
US 9867652B2 · Sano et al. · 2018 [cited by applicant]
US 9918789B2 · Bagley et al. · 2018 [cited by applicant]
US 9924991B2 · West et al. · 2018 [cited by applicant]
US 9937344B2 · Starkebaum et al. · 2018 [cited by applicant]
US 9988885B1 · Shahinpour et al. · 2018 [cited by applicant]
US 9993297B2 · Ben-Oren et al. · 2018 [cited by applicant]
US 9999467B2 · Moss et al. · 2018 [cited by applicant]
US 10004558B2 · Long et al. · 2018 [cited by applicant]
US 10010666B2 · Rubinsky et al. · 2018 [cited by applicant]
US 10016232B1 · Bowers et al. · 2018 [cited by applicant]
US 10039596B2 · Zarins et al. · 2018 [cited by applicant]
US 10064697B2 · Sharma et al. · 2018 [cited by applicant]
US 10070914B2 · Schoenbach et al. · 2018 [cited by applicant]
US 10117701B2 · Davalos et al. · 2018 [cited by applicant]
US 10154874B2 · Davalos et al. · 2018 [cited by applicant]
US 10154876B2 · Callas et al. · 2018 [cited by applicant]
US 10238447B2 · Neal, II et al. · 2019 [cited by applicant]
US 10245098B2 · Davalos et al. · 2019 [cited by applicant]
US 10245105B2 · Davalos · 2019 [cited by applicant]
US 10292755B2 · Arena et al. · 2019 [cited by applicant]
US 10299857B2 · Rajagopalan et al. · 2019 [cited by applicant]
US 10322286B2 · Viswanathan et al. · 2019 [cited by applicant]
US 10342598B2 · Long et al. · 2019 [cited by applicant]
US 10349998B2 · Levin et al. · 2019 [cited by applicant]
US 10350004B2 · Gifford, III et al. · 2019 [cited by applicant]
US 10368944B2 · Schaer · 2019 [cited by applicant]
US 10448989B2 · Arena et al. · 2019 [cited by applicant]
US 10463426B2 · Chornenky et al. · 2019 [cited by applicant]
US 10548653B2 · Hoey et al. · 2020 [cited by applicant]
US 10558665B2 · Mazumder · 2020 [cited by applicant]
US 10569081B2 · Howard · 2020 [cited by applicant]
US 10582963B2 · Woloszko et al. · 2020 [cited by applicant]
US 10610663B2 · Rajagopalan et al. · 2020 [cited by applicant]
US 10614949B2 · Smith et al. · 2020 [cited by applicant]
US 10722302B2 · Sherman et al. · 2020 [cited by applicant]
US 10722305B2 · Moss et al. · 2020 [cited by applicant]
US 10765474B2 · Kadamus et al. · 2020 [cited by applicant]
US 10842668B2 · Singh · 2020 [cited by applicant]
US 10856926B2 · Azamian et al. · 2020 [cited by applicant]
US 10869718B2 · Rajagopalan et al. · 2020 [cited by applicant]
US 10881455B2 · Schwartz et al. · 2021 [cited by applicant]
US 10888377B2 · Ben-Oren et al. · 2021 [cited by applicant]
US 10898263B2 · Bagley et al. · 2021 [cited by applicant]
US 10912609B2 · De La Rama et al. · 2021 [cited by applicant]
US 10939949B2 · Rubinsky et al. · 2021 [cited by applicant]
US 10946193B2 · Athos et al. · 2021 [cited by applicant]
US 10953241B2 · Luttrull et al. · 2021 [cited by applicant]
US 10959774B2 · Kadamus et al. · 2021 [cited by applicant]
US 10973561B2 · Caplan et al. · 2021 [cited by applicant]
US 10987149B2 · Rajagopalan et al. · 2021 [cited by applicant]
US 11103674B2 · Rajagopalan et al. · 2021 [cited by applicant]
US 11185367B2 · Rajagopalan et al. · 2021 [cited by applicant]
US 11246639B2 · Rajagopalan et al. · 2022 [cited by applicant]
US 11254926B2 · Neal, II et al. · 2022 [cited by applicant]
US 11272979B2 · Garcia et al. · 2022 [cited by applicant]
US 11278349B2 · Stewart et al. · 2022 [cited by applicant]
US 11298175B2 · Konings · 2022 [cited by applicant]
US 11311333B2 · Rajagopalan et al. · 2022 [cited by applicant]
US 11337749B2 · Desimone et al. · 2022 [cited by applicant]
US 11357978B2 · Bowers et al. · 2022 [cited by applicant]
US 11364072B2 · Howard et al. · 2022 [cited by applicant]
US 11376064B2 · Rankin · 2022 [cited by applicant]
US 11382681B2 · Arena et al. · 2022 [cited by applicant]
US 11389171B2 · Goldsmith · 2022 [cited by applicant]
US 11419659B2 · Levin et al. · 2022 [cited by applicant]
US 11439457B2 · Caplan et al. · 2022 [cited by applicant]
US 11453873B2 · Davalos et al. · 2022 [cited by applicant]
US 11464968B2 · Howard · 2022 [cited by applicant]
US 11471208B2 · Waldstreicher et al. · 2022 [cited by applicant]
US 11547851B2 · Krimsky et al. · 2023 [cited by applicant]
US 11596474B2 · Van Der Weide et al. · 2023 [cited by applicant]
US 11638603B2 · Sano et al. · 2023 [cited by applicant]
US 11638819B2 · Gundert et al. · 2023 [cited by applicant]
US 11655466B2 · Neal, II et al. · 2023 [cited by applicant]
US 11723712B2 · Athos et al. · 2023 [cited by applicant]
US 11826521B2 · Rajagopalan et al. · 2023 [cited by applicant]
US 11878128B2 · Rajagopalan et al. · 2024 [cited by applicant]
US 11912975B2 · Soden et al. · 2024 [cited by applicant]
US 20010044596A1 · Jaafar · 2001 [cited by applicant]
US 20020087208A1 · Koblish et al. · 2002 [cited by applicant]
US 20030055464A1 · Darvish · 2003 [cited by examiner]
US 20030093072A1 · Friedman · 2003 [cited by applicant]
US 20030153905A1 · Edwards et al. · 2003 [cited by applicant]
US 20030181898A1 · Bowers · 2003 [cited by applicant]
US 20030236496A1 · Samson et al. · 2003 [cited by applicant]
US 20040095100A1 · Thompson · 2004 [cited by applicant]
US 20040215180A1 · Starkebaum et al. · 2004 [cited by applicant]
US 20040215296A1 · Ganz et al. · 2004 [cited by applicant]
US 20040220559A1 · Kramer et al. · 2004 [cited by applicant]
US 20040236376A1 · Miklavcic et al. · 2004 [cited by applicant]
US 20050090873A1 · Imran · 2005 [cited by examiner]
US 20050183732A1 · Edwards · 2005 [cited by examiner]
US 20050192652A1 · Cioanta et al. · 2005 [cited by applicant]
US 20050234293A1 · Yamamoto et al. · 2005 [cited by applicant]
US 20060084962A1 · Joye et al. · 2006 [cited by applicant]
US 20060095032A1 · Jackson et al. · 2006 [cited by applicant]
US 20060135963A1 · Kick et al. · 2006 [cited by applicant]
US 20060217698A1 · Starkebaum et al. · 2006 [cited by applicant]
US 20060293730A1 · Rubinsky et al. · 2006 [cited by applicant]
US 20070016262A1 · Gross · 2007 [cited by examiner]
US 20070043345A1 · Davalos et al. · 2007 [cited by applicant]
US 20070100355A1 · Bonde et al. · 2007 [cited by applicant]
US 20070225800A1 · Sahatjian · 2007 [cited by applicant]
US 20080058786A1 · Boyden et al. · 2008 [cited by applicant]
US 20080058887A1 · Griffin · 2008 [cited by examiner]
US 20080207994A1 · Gonon · 2008 [cited by applicant]
US 20080223380A1 · Chinn · 2008 [cited by applicant]
US 20080275445A1 · Kelly · 2008 [cited by examiner]
US 20090012469A1 · Nita · 2009 [cited by applicant]
US 20090203995A1 · Matonick · 2009 [cited by applicant]
US 20090248012A1 · Maor et al. · 2009 [cited by applicant]
US 20090269317A1 · Davalos · 2009 [cited by applicant]
US 20090281477A1 · Mikus · 2009 [cited by examiner]
US 20100023004A1 · Francischelli et al. · 2010 [cited by applicant]
US 20100023047A1 · Simpson · 2010 [cited by applicant]
US 20100114325A1 · Yang et al. · 2010 [cited by applicant]
US 20100179530A1 · Long et al. · 2010 [cited by applicant]
US 20100191235A1 · Moshe et al. · 2010 [cited by applicant]
US 20100204560A1 · Salahieh et al. · 2010 [cited by applicant]
US 20100210994A1 · Zarif · 2010 [cited by applicant]
US 20100222677A1 · Placek et al. · 2010 [cited by applicant]
US 20100249771A1 · Pearson et al. · 2010 [cited by applicant]
US 20100256630A1 · Hamilton et al. · 2010 [cited by applicant]
US 20110091564A1 · Chu · 2011 [cited by applicant]
US 20110106273A1 · Belhe et al. · 2011 [cited by applicant]
US 20110118732A1 · Rubinsky et al. · 2011 [cited by applicant]
US 20110144635A1 · Harper et al. · 2011 [cited by applicant]
US 20110160514A1 · Long et al. · 2011 [cited by applicant]
US 20110172659A1 · Brannan · 2011 [cited by applicant]
US 20110208175A1 · Sobotka et al. · 2011 [cited by applicant]
US 20110224768A1 · Edwards · 2011 [cited by applicant]
US 20110288543A1 · Cheng et al. · 2011 [cited by applicant]
US 20120010610A1 · Keppel · 2012 [cited by applicant]
US 20120041465A1 · Shalon · 2012 [cited by applicant]
US 20120059255A1 · Paul et al. · 2012 [cited by applicant]
US 20120109122A1 · Arena et al. · 2012 [cited by applicant]
US 20120116266A1 · Houser et al. · 2012 [cited by applicant]
US 20120191089A1 · Gonzalez et al. · 2012 [cited by applicant]
US 20120259269A1 · Meyer · 2012 [cited by applicant]
US 20130030430A1 · Stewart et al. · 2013 [cited by applicant]
US 20130178910A1 · Azamian · 2013 [cited by examiner]
US 20130184702A1 · Neal, II et al. · 2013 [cited by applicant]
US 20130190675A1 · Sandoski · 2013 [cited by applicant]
US 20130345670A1 · Rajagopalan et al. · 2013 [cited by applicant]
US 20140031810A1 · Mahvi et al. · 2014 [cited by applicant]
US 20140074077A1 · Lane · 2014 [cited by applicant]
US 20140088362A1 · Terliuc et al. · 2014 [cited by applicant]
US 20140088529A1 · Bengtson · 2014 [cited by applicant]
US 20140114304A1 · Wang et al. · 2014 [cited by applicant]
US 20140121646A1 · Lodin et al. · 2014 [cited by applicant]
US 20140135606A1 · Yasui · 2014 [cited by applicant]
US 20140214026A1 · Degen · 2014 [cited by applicant]
US 20140371736A1 · Levin et al. · 2014 [cited by applicant]
US 20150141987A1 · Caplan et al. · 2015 [cited by applicant]
US 20150148738A1 · Caplan et al. · 2015 [cited by applicant]
US 20150164584A1 · Davalos et al. · 2015 [cited by applicant]
US 20150173824A1 · Davalos et al. · 2015 [cited by applicant]
US 20150182282A1 · Zemel · 2015 [cited by examiner]
US 20150182735A1 · Chang et al. · 2015 [cited by applicant]
US 20150216592A1 · Gnanashanmugam et al. · 2015 [cited by applicant]
US 20150289923A1 · Davalos et al. · 2015 [cited by applicant]
US 20150327944A1 · Neal, II et al. · 2015 [cited by applicant]
US 20160051324A1 · Stewart et al. · 2016 [cited by applicant]
US 20160058493A1 · Neal, II et al. · 2016 [cited by applicant]
US 20160066977A1 · Neal, II et al. · 2016 [cited by applicant]
US 20160081745A1 · Rajagopalan et al. · 2016 [cited by applicant]
US 20160175582A1 · Serna et al. · 2016 [cited by applicant]
US 20160235470A1 · Callas et al. · 2016 [cited by applicant]
US 20160287314A1 · Arena et al. · 2016 [cited by applicant]
US 20160331441A1 · Konings · 2016 [cited by applicant]
US 20160338761A1 · Chornenky et al. · 2016 [cited by applicant]
US 20160354142A1 · Pearson et al. · 2016 [cited by applicant]
US 20160361109A1 · Weaver et al. · 2016 [cited by applicant]
US 20160367310A1 · Onik et al. · 2016 [cited by applicant]
US 20160374754A1 · Asirvatham et al. · 2016 [cited by applicant]
US 20170000559A1 · Rioux et al. · 2017 [cited by applicant]
US 20170014183A1 · Gifford, III et al. · 2017 [cited by applicant]
US 20170035501A1 · Chornenky et al. · 2017 [cited by applicant]
US 20170095290A1 · Sherman et al. · 2017 [cited by applicant]
US 20170105781A1 · Pasricha et al. · 2017 [cited by applicant]
US 20170112562A1 · Woloszko et al. · 2017 [cited by applicant]
US 20170203132A1 · Luttrull et al. · 2017 [cited by applicant]
US 20170232269A1 · Luttrull et al. · 2017 [cited by applicant]
US 20170245928A1 · Xiao et al. · 2017 [cited by applicant]
US 20170265929A1 · Callas et al. · 2017 [cited by applicant]
US 20170333122A1 · Rajagopalan et al. · 2017 [cited by applicant]
US 20170348049A1 · Vrba et al. · 2017 [cited by applicant]
US 20180021084A1 · Onik et al. · 2018 [cited by applicant]
US 20180028252A1 · Lalonde · 2018 [cited by applicant]
US 20180028264A1 · Onik et al. · 2018 [cited by applicant]
US 20180042661A1 · Long et al. · 2018 [cited by applicant]
US 20180043153A1 · Viswanathan et al. · 2018 [cited by applicant]
US 20180071014A1 · Neal et al. · 2018 [cited by applicant]
US 20180125575A1 · Schwartz et al. · 2018 [cited by applicant]
US 20180193082A1 · Rubinsky et al. · 2018 [cited by applicant]
US 20180193090A1 · de la Rama et al. · 2018 [cited by applicant]
US 20180193590A1 · Rajagopalan et al. · 2018 [cited by applicant]
US 20180214202A1 · Howard et al. · 2018 [cited by applicant]
US 20180221622A1 · Rajagopalan et al. · 2018 [cited by applicant]
US 20180250074A1 · Ben-Oren et al. · 2018 [cited by applicant]
US 20180250508A1 · Howard · 2018 [cited by applicant]
US 20180263694A1 · Moss et al. · 2018 [cited by applicant]
US 20190069949A1 · Vrba et al. · 2019 [cited by applicant]
US 20190175248A1 · Neal, II et al. · 2019 [cited by applicant]
US 20190223938A1 · Arena et al. · 2019 [cited by applicant]
US 20190223948A1 · Stewart et al. · 2019 [cited by applicant]
US 20190233809A1 · Neal, II et al. · 2019 [cited by applicant]
US 20190254740A1 · Koya et al. · 2019 [cited by applicant]
US 20190256839A1 · Neal, II et al. · 2019 [cited by applicant]
US 20190282294A1 · Davalos et al. · 2019 [cited by applicant]
US 20190328445A1 · Sano et al. · 2019 [cited by applicant]
US 20190344053A1 · Wang et al. · 2019 [cited by applicant]
US 20190376055A1 · Davalos et al. · 2019 [cited by applicant]
US 20200060758A1 · Rajagopalan et al. · 2020 [cited by applicant]
US 20200060942A1 · Rajagopalan et al. · 2020 [cited by applicant]
US 20200093541A9 · Neal, II et al. · 2020 [cited by applicant]
US 20200129230A1 · Forsyth et al. · 2020 [cited by applicant]
US 20200155217A1 · Morneau et al. · 2020 [cited by applicant]
US 20200315700A1 · Petitpierre et al. · 2020 [cited by applicant]
US 20200323576A1 · Neal et al. · 2020 [cited by applicant]
US 20210113265A1 · D'agostino et al. · 2021 [cited by applicant]
US 20210161582A1 · Byrd et al. · 2021 [cited by applicant]
US 20210393327A1 · Eyster et al. · 2021 [cited by applicant]
US 20220022952A1 · Koop et al. · 2022 [cited by applicant]
US 20220054184A9 · Rajagopalan et al. · 2022 [cited by applicant]
US 20220071700A1 · Desimone · 2022 [cited by applicant]
US 20220117658A1 · Rajagopalan et al. · 2022 [cited by applicant]
US 20220265337A1 · Rajagopalan et al. · 2022 [cited by applicant]
US 20220331601A1 · D'Agostino et al. · 2022 [cited by applicant]
US 20220354571A1 · Caplan et al. · 2022 [cited by applicant]
US 20230000543A1 · Sano et al. · 2023 [cited by applicant]
US 20230149706A1 · Krimsky et al. · 2023 [cited by applicant]
US 20230165621A1 · Biasella et al. · 2023 [cited by applicant]
US 20230172650A1 · Castellvi et al. · 2023 [cited by applicant]
US 20230200883A1 · Caplan et al. · 2023 [cited by applicant]
US 20230233250A1 · Rajagopalan et al. · 2023 [cited by applicant]
US 20230310066A1 · Tegg et al. · 2023 [cited by applicant]
US 20230380897A1 · Liu et al. · 2023 [cited by applicant]
US 20230414274A1 · Moss et al. · 2023 [cited by applicant]
US 20240016536A1 · Kato et al. · 2024 [cited by applicant]
US 20240156523A1 · D'Agostino et al. · 2024 [cited by applicant]
US 20240180613A1 · D'Agostino et al. · 2024 [cited by applicant]
AU 2014200616A1 · 2014 [cited by applicant]
CN 103517731A · 2014 [cited by applicant]
EP 2865349A1 · 2015 [cited by applicant]
EP 3050531A1 · 2016 [cited by applicant]
EP 3316813A1 · 2018 [cited by applicant]
EP 3169260B1 · 2019 [cited by applicant]
JP 2015097780A · 2015 [cited by applicant]
JP 2019516512A · 2019 [cited by applicant]
WO WO199116945A1 · 1991 [cited by applicant]
WO WO9519735A1 · 1995 [cited by applicant]
WO WO199815318A1 · 1998 [cited by applicant]
WO WO200035349A1 · 2000 [cited by applicant]
WO WO2001068015 · 2001 [cited by applicant]
WO WO2005089433A2 · 2005 [cited by applicant]
WO WO2005089433A3 · 2005 [cited by applicant]
WO WO2008137757A1 · 2008 [cited by applicant]
WO WO2009009444A1 · 2009 [cited by applicant]
WO WO2009132190A2 · 2009 [cited by applicant]
WO WO2011017387A3 · 2011 [cited by applicant]
WO WO2011047387A2 · 2011 [cited by applicant]
WO WO2011072221A1 · 2011 [cited by applicant]