Immunotherapy against several tumors including neuronal and brain tumors
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
1. A peptide consisting of the amino acid sequence of TLVGIIVGV (SEQ ID NO: 22) in the form of pharmaceutically acceptable salt, wherein said peptide is produced by solid phase peptide synthesis or produced by a yeast cell or bacterial cell expression system.
2. A pegylated peptide consisting of the amino acid sequence of TLVGIIVGV (SEQ ID NO: 22) or a pharmaceutically acceptable salt thereof.
3. A composition comprising a peptide consisting of the amino acid sequence of TLVGIIVGV (SEQ ID NO: 22) in the form of pharmaceutically acceptable salt and an immune-stimulating adjuvant.
4. A composition comprising the pegylated peptide of claim 2 or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
5. The peptide of claim 1 , wherein the pharmaceutical pharmaceutically acceptable salt is a chloride salt or acetate salt.
6. A peptide consisting of the amino acid sequence of TLVGIIVGV (SEQ ID NO: 22), wherein at least one amino acid of the peptide is a D-amino acid.
7. The composition of claim 3 , wherein the adjuvant is selected from the group consisting of interleukin (IL)-1, IL-2, IL-4, IL-7, IL-12, IL-13, IL-15, IL-21, and IL-23.
8. The composition of claim 7 , wherein the adjuvant is IL-2.
9. The composition of claim 7 , wherein the adjuvant is IL-7.