IP Library › Granted Patent US 10,030,033
Granted Patent B2
US 10,030,033 · App. 15/227,527 · Granted Jul 24, 2018

Synthesis of an antiviral compound

Inventors: Amy Cagulada (San Francisco, CA); Johann Chan (Foster City, CA); Lina Chan (Foster City, CA); Denise A. Colby (San Francisco, CA); Kapil Kumar Karki (Foster City, CA); Darryl Kato (San Francisco, CA); Katie Ann Keaton (Burlingame, CA); Sudha Kondappally (Foster City, CA); Chris Levins (Redwood City, CA); Adam Littke (Oakland, CA); Ruben Martinez (San Diego, CA); Dominika Pcion (Foster City, CA); Troy Reynolds (San Francisco, CA); Bruce Ross (El Granada, CA); Michael Sangi (San Mateo, CA); Adam J. Schrier (Redwood City, CA); Pamela Seng (San Francisco, CA); Dustin Siegel (Half Moon Bay, CA); Nathan Shapiro (Belmont, CA); Donald Tang (Millbrae, CA); James G. Taylor (Burlingame, CA); Jonathan Tripp (San Mateo, CA); Andrew W. Waltman (San Francisco, CA); Lawrence Yu (Foster City, CA)
Assignee: GILEAD SCIENCES, INC.
C07D498/18C07C205/57C07C233/09C07C251/12C07C255/61C07C271/34C07D241/44C07D403/12C07C2601/02
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,030,033
App. No.
15/227,527
Granted
Jul 24, 2018
Kind
B2
Abstract

The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Claims (14)

1. A compound selected from the group consisting of formula, V, VI, XV, XVIII, and XIX:

or a salt thereof, wherein R is C 1-6 alkyl and PG is a protective group.

2. The compound of claim 1 which is of formula V:

or a salt thereof, wherein R is C 1-6 alkyl and PG is a protective group.

3. The compound of claim 1 which is of formula VI:

or a salt thereof, wherein R is C 1-6 alkyl.

4. The compound of claim 1 which is of formula VIII:

or a salt thereof, wherein R is C 1-6 alkyl.

5. The compound of claim 1 which is of formula XV:

or a salt thereof, wherein R is C 1-6 alkyl and PG is a protective group.

6. The compound of claim 1 which is of formula XVIII:

or a salt thereof.

7. The compound of claim 1 which is of formula XIX:

or a salt thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2016
From: CAGULADA, AMY; CHAN, JOHANN; CHAN, LINA; KARKI, KAPIL KUMAR; KATO, DARRYL; KEATON, KATIE ANN; KONDAPALLY, SUDHA; LEVINS, CHRIS; LITTKE, ADAM; MARTINEZ, RUBEN; PCION, DOMINIKA; REYNOLDS, TROY; ROSS, BRUCE; SANGI, MICHAEL; SCHRIER, ADAM J.; SENG, PAMELA; SIEGEL, DUSTIN; SHAPIRO, NATHAN; TANG, DONALD; TAYLOR, JAMES G.; TRIPP, JONATHAN; WALTMAN, ANDREW W.; YU, LAWRENCE; COLBY, DENISE A.
To: GILEAD SCIENCES, INC.
Reel/Frame 039862/0180 →
Continuity (3)
Continuation 14576143 · Dec 18, 2014
Provisional Application 61920446 · Dec 23, 2013
Related Publication 20170210756A1 · Jul 27, 2017