Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
Systems, devices, and method for performing pulmonary artery denervation are disclosed. An ablation device is positioned in a pulmonary artery trunk of a patient. Target tissue is ablated in the pulmonary artery trunk under conditions effective to affect a reduction in mean pulmonary artery pressure and systolic pulmonary artery pressure. The target tissue includes at least one of the distal portion of the main pulmonary artery, the proximal portion of the left pulmonary artery, or the proximal portion of the right pulmonary artery.
1. A method of performing pulmonary artery denervation comprising:
positioning an ablation device in a pulmonary artery trunk of a patient, the pulmonary artery trunk including a distal portion of a main pulmonary artery, a proximal portion of a left pulmonary artery, and a proximal portion of a right pulmonary artery; and
ablating target tissue in the pulmonary artery trunk under conditions effective to affect a reduction in mean pulmonary artery pressure of the patient,
wherein the target tissue comprises at least one of the distal portion of the main pulmonary artery, the proximal portion of the left pulmonary artery, or the proximal portion of the right pulmonary artery with the ablation device,
wherein the conditions effective to affect the reduction in mean pulmonary artery pressure also affect a reduction in systolic pulmonary artery pressure.
2. The method of claim 1 , wherein the reduction in mean pulmonary artery pressure is about 10%.
3. The method of claim 1 , wherein the reduction in mean pulmonary artery pressure is about 30%.
4. The method of claim 1 , wherein the reduction in systolic pulmonary artery pressure is about 10%.
5. The method of claim 1 , wherein the reduction in systolic pulmonary artery pressure is about 30%.
6. The method of claim 1 , wherein ablating the target tissue comprises ablating the target tissue at a temperature of about 50° degrees C. to about 60° degrees C.
7. The method of claim 1 , wherein ablating the target tissue comprises ablating the target tissue with an energy of between about 8 W to about 10 W.
8. The method of claim 1 , wherein ablating the target tissue comprises ablating the target tissue for between about 60 and about 120 seconds.
9. The method of claim 1 , wherein ablating the target tissue comprises applying at least one of radiofrequency (RF) energy, microwave energy, ultrasound energy, focused ultrasound energy, ionizing energy, electroporation, a drug, a chemical agent, or cryoablation to the target tissue.
10. The method of claim 1 , wherein ablating the target tissue causes disruption of sympathetic nerves at the pulmonary artery trunk.
11. The method of claim 1 , wherein ablating the target tissue comprises generating a continuous ablation pattern.
12. The method of claim 1 , wherein ablating the target tissue comprises generating a non-continuous ablation pattern.
13. The method of claim 1 , wherein ablating the target tissue comprises ablating the target tissue with a distal annular ring of the ablation device, the distal annular ring comprising one or more ablation electrodes.
14. The method of claim 1 , wherein positioning the ablation device in the pulmonary artery trunk of the patient comprises passing the ablation device into a femoral vein of the patient, upwardly into an inferior vena cava of the patient, then upwards into a right atrium of the patient, then down into a right ventricle of the patient, and then up through a pulmonary semilunar valve of the patient to the main pulmonary artery trunk.
15. The method of claim 1 , further comprising visualizing at least one of the main pulmonary artery trunk or the ablation device positioned in the main pulmonary artery trunk to confirm to positioning of the ablation device.
16. The method of claim 1 , further comprising visualizing the main pulmonary artery prior to positioning the ablation device in the pulmonary artery trunk.
17. The method of claim 1 , wherein the main pulmonary artery is visualized with one or more of magnetic resonance imaging (MRI) or computed tomograpghy (CT) scanning.
18. The method of claim 1 , further comprising withdrawing the ablation device from the main pulmonary artery after the target tissue has been ablated.
19. The method of claim 18 , further comprising visualizing the main pulmonary artery after the ablation device has been withdrawn.
20. The method of claim 1 , wherein the ablated target tissue comprises the distal portion of the main pulmonary artery and the proximal portion of the left pulmonary artery.
21. The method of claim 1 , wherein the ablated target tissue comprises the distal portion of the main pulmonary artery and the proximal portion of the right pulmonary artery.
22. The method of claim 1 , wherein the ablated target tissue comprises the proximal portion of the left pulmonary artery and the proximal portion of the right pulmonary artery.
23. The method of claim 1 , wherein the ablated target tissue comprises the distal portion of the main pulmonary artery, the proximal portion of the left pulmonary artery, and the proximal portion of the right pulmonary artery.
24. The method of claim 1 , wherein ablating the target tissue comprises ablating an anterior wall of the distal portion of the main pulmonary artery.
25. The method of claim 1 , wherein ablating the target tissue comprises ablating a posterior wall of the right pulmonary artery.
26. The method of claim 1 , wherein positioning the ablation device comprises positioning a distal annular ring adjacent the target tissue.
27. The method of claim 26 , wherein positioning the distal annular ring comprises one or more of rotating or pushing a handle of the ablation device.