IP Library › Granted Patent US 12,544,130
Granted Patent B2
US 12,544,130 · App. 18/365,099 · Granted Feb 10, 2026

Systems and methods for applying energy to denervate a pulmonary artery

Inventors: David Amaoua (Versailles, FR); Martin Grasse (Basel, CH); William Cannon (County Galway, IE)
Assignee: Gradient Denervation Technologies SAS
A61B18/1492A61N7/02A61B2018/0022A61B2018/00434A61B2018/00577A61N2007/003A61N2007/0091
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,544,130
App. No.
18/365,099
Granted
Feb 10, 2026
Kind
B2
Abstract

A catheter system for ablation of tissue around a blood vessel, e.g., the pulmonary artery, to reduce neural activity of nerves surrounding the blood vessel. The catheter system includes an elongate shaft having a proximal portion coupled to a handle, and a distal portion. The distal portion includes a transducer and an expandable anchor, which may be actuated to transition between a collapsed delivery state and an expanded deployed state where the anchor centralizes the transducer within the blood vessel. The transducer may be actuated to emit energy to reduce neural activity of the nerves surrounding the blood vessel. Systems and method are further provided for confirming that neural activity of the nerves surround the blood vessel has been sufficiently reduced.

Claims (63)

1 . A system for reducing neural activity of nerves around a blood vessel of a patient, the system comprising:

a catheter assembly comprising a proximal region operatively coupled to a handle and a distal region sized and shaped to be positioned within the blood vessel;

an ultrasound transducer disposed at the distal region of the catheter assembly parallel to a longitudinal axis of the catheter assembly, the ultrasound transducer configured to be actuated to emit ultrasonic energy within the blood vessel to reduce neural activity of nerves around the blood vessel; and

an expandable metal anchor disposed at the distal region of the catheter assembly such that the ultrasound transducer is disposed entirely within the expandable metal anchor, the expandable metal anchor comprising a plurality of struts and configured to transition between a collapsed delivery state and an expanded deployed state wherein, in the expanded deployed state, the plurality of struts of the expandable metal anchor are configured to form a cage having a profile that extends in a direction parallel to the longitudinal axis of the catheter assembly across an entire length of the ultrasound transducer and are spaced apart from the ultrasound transducer,

wherein, in the expanded deployed state, the cage is sized and shaped to contact an inner wall of the blood vessel without occluding the blood vessel to centralize the ultrasound transducer within the blood vessel such that the ultrasound transducer is spaced apart from the inner wall of the blood vessel while preserving blood flow through the blood vessel, and

wherein, in the expanded deployed state, an entire length of the parallel extending portion of the cage is configured to contact the inner wall of the blood vessel.

2 . The system of claim 1 , wherein, in the expanded deployed state, the cage is configured to apply a force to the inner wall of the blood vessel to distend the blood vessel without occluding the blood vessel.

3 . The system of claim 2 , wherein the force applied to the inner wall of the blood vessel by the cage in the expanded deployed state is sufficient to distend the blood vessel and stimulate baroreceptors within the blood vessel.

4 . The system of claim 1 , wherein the handle is configured to permit a user to feel when the expandable metal anchor contacts the inner wall of the blood vessel in the expanded deployed state upon actuation at the handle.

5 . The system of claim 1 , wherein the catheter assembly comprises:

an inner catheter comprising a guidewire lumen extending through at least a portion of a length of the inner catheter;

a transducer shaft comprising a lumen sized and shaped to slidably receive the inner catheter therein, wherein the ultrasound transducer is disposed on the transducer shaft; and

an outer catheter comprising a lumen sized and shaped to receive the transducer shaft therein,

wherein a distal end of the expandable metal anchor is coupled to the inner catheter and a proximal end of the expandable metal anchor is coupled to the outer catheter, such that, upon actuation at the handle, relative movement between the inner catheter and the outer catheter causes the expandable metal anchor to transition between the collapsed delivery state and the expanded deployed state.

6 . The system of claim 5 , wherein the catheter assembly further comprises a sheath comprising:

a proximal region operatively coupled to the handle;

a distal region; and

a lumen sized and shaped to slidably receive the outer catheter and the expandable metal anchor in the collapsed delivery state therein,

wherein the distal region of the sheath comprises a stiffness sufficient to facilitate transitioning of the expandable metal anchor from the expanded deployed state to the collapsed delivery state upon movement of the distal region of the sheath relative to the expandable metal anchor without buckling the distal region of the sheath.

7 . The system of claim 1 , wherein the expandable metal anchor comprises a shape memory material.

8 . The system of claim 1 , wherein the plurality of struts extend from a proximal end of the expandable metal anchor to a distal end of the expandable metal anchor, the plurality of struts comprising a plurality of connections configured to form diamond-shaped struts in the expanded deployed state.

9 . The system of claim 8 , wherein the plurality of struts comprise round edges formed via an electropolishing treatment.

10 . The system of claim 1 , wherein, in the expanded deployed state, the profile of the expandable metal anchor comprises a rectangular shape configured to reduce slipping of the expandable metal anchor over the inner wall of the blood vessel.

11 . The system of claim 1 , wherein, in the expanded deployed state, the expandable metal anchor is configured to exert a radial force to the inner wall of the blood vessel that is greater than a stiffness force of the catheter assembly to centralize the ultrasound transducer within a curved portion of the blood vessel.

12 . The system of claim 1 , further comprising:

one or more sensors configured to measure pressure within the blood vessel; and

a controller operatively coupled to the one or more sensors, the controller programmed to:

receive first pressure information within the blood vessel from the one or more sensors at a first time;

receive second pressure information within the blood vessel from the one or more sensors at a second time while a distension mechanism applies a first force to the inner wall of the blood vessel sufficient to distend the blood vessel and stimulate baroreceptors within the blood vessel;

receive, after ultrasonic energy is emitted within the blood vessel via the ultrasound transducer, third pressure information within the blood vessel from the one or more sensors at a third time while the distension mechanism applies a second force to the inner wall of the blood vessel sufficient to distend the blood vessel and stimulate baroreceptors within the blood vessel; and

compare the second pressure information to the third pressure information to determine whether the ultrasonic energy has reduced neural activity of nerves around the blood vessel.

13 . The system of claim 12 , wherein the second pressure information is indicative of a first pressure gradient between pressure within the blood vessel while the first force is applied to the inner wall of the blood vessel and pre-distension pressure within the blood vessel associated with the first pressure information, and wherein the third pressure information is indicative of a second pressure gradient between pressure within the blood vessel while the second force is applied to the inner wall of the blood vessel and pre-distension pressure within the blood vessel associated with the first pressure information.

14 . The system of claim 13 , wherein the controller is programmed to determine that the ultrasonic energy has reduced neural activity of nerves around the blood vessel if the comparison of the second and third pressure information indicates that the second pressure gradient is less than the first pressure gradient by more than a predetermined threshold.

15 . The system of claim 13 , wherein the controller is programmed to determine that the ultrasonic energy has reduced neural activity of nerves around the blood vessel if the second pressure gradient is zero.

16 . The system of claim 12 , wherein the expandable metal anchor comprises the distension mechanism.

17 . The system of claim 12 , wherein the distension mechanism comprises a torqueing mechanism configured to bend a shaft of the catheter assembly within the blood vessel to apply force to the inner wall of the blood vessel.

18 . The system of claim 1 , wherein, in the expanded state, the cage is sized and shaped to contact an inner wall of a pulmonary artery without occluding the pulmonary artery to centralize the ultrasound transducer within the pulmonary artery such that the ultrasound transducer is spaced apart from the inner wall of the pulmonary artery while preserving blood flow through the pulmonary artery.

19 . The system of claim 1 , further comprising a generator operatively coupled to the ultrasound transducer, the generator configured to be actuated to provide electrical energy to the ultrasound transducer to cause the ultrasound transducer to emit ultrasonic energy.

20 . The system of claim 19 , further comprising:

a sensor configured to measure temperature of the ultrasound transducer,

wherein the generator comprises a control loop configured to adapt the electric energy provided to the ultrasound transducer if the temperature of the ultrasound transducer exceeds a predetermined threshold.

21 . A method for reducing neural activity of nerves around a blood vessel of a patient, the method comprising:

selecting a catheter assembly comprising a handle, an expandable metal anchor comprising a plurality of struts disposed at a distal region of the catheter assembly, and an ultrasound transducer disposed entirely within the expandable metal anchor parallel to a longitudinal axis of the catheter assembly;

advancing, while the expandable metal anchor is in a collapsed delivery state over the ultrasound transducer, the distal region of the catheter assembly into the patient until the ultrasound transducer is at a target location within the blood vessel;

transitioning, via the handle, the expandable metal anchor from the collapsed delivery state to an expanded deployed state where the plurality of struts of the expandable metal anchor forms a cage having a profile that extends in a direction parallel to the longitudinal axis of the catheter assembly across an entire length of the ultrasound transducer and are spaced apart from the ultrasound transducer, wherein, in the expanded deployed state, the cage is sized and shaped to contact an inner wall of the blood vessel without occluding the blood vessel to centralize the ultrasound transducer within the blood vessel such that the ultrasound transducer is spaced apart from the inner wall of the blood vessel while preserving blood flow through the blood vessel, and wherein, in the expanded deployed state, an entire length of the parallel extending portion of the cage is configured to contact the inner wall of the blood vessel;

actuating the ultrasound transducer to emit ultrasonic energy within the blood vessel to reduce neural activity of nerves around the blood vessel;

transitioning, via the handle, the expandable metal anchor from the expanded deployed state to the collapsed delivery state; and

removing the catheter assembly from the patient.

22 . The method of claim 21 , wherein advancing the distal region of the catheter assembly into the patient until the ultrasound transducer is at the target location within the blood vessel comprises advancing the distal region of the catheter assembly into the patient while the distal region is disposed within a sheath such that the expandable metal anchor is in the collapsed delivery state within the sheath, the method further comprising:

retracting the sheath to expose the expandable metal anchor within the blood vessel prior to transitioning the expandable metal anchor from the collapsed delivery state to the expanded deployed state within the blood vessel.

23 . The method of claim 22 , wherein transitioning the expandable metal anchor from the expanded deployed state to the collapsed delivery state comprises advancing a distal region of the sheath over the expandable metal anchor to facilitate transitioning of the expandable metal anchor from the expanded deployed state to the collapsed delivery state without buckling the distal region of the sheath.

24 . The method of claim 21 , wherein a proximal end of the expandable metal anchor is coupled to an outer catheter of the catheter assembly and a distal end of the expandable metal anchor is coupled to an inner catheter of the catheter assembly slidably disposed within the outer catheter,

wherein transitioning the expandable metal anchor from the collapsed delivery state to the expanded deployed state comprises actuating the handle to cause relative movement between the inner catheter and the outer catheter to cause the expandable metal anchor to transition from the collapsed delivery state to the expanded deployed state, and

wherein transitioning the expandable metal anchor from the expanded deployed state to the collapsed delivery state comprises actuating the handle to cause relative movement between the inner catheter and the outer catheter to cause the expandable metal anchor to transition from the expanded deployed state to the collapsed delivery state.

25 . The method of claim 21 , wherein the plurality of struts extend from a proximal end of the expandable metal anchor to a distal end of the expandable metal anchor, the plurality of struts comprising a plurality of connections configured to form diamond-shaped struts in the expanded deployed state.

26 . The method of claim 21 , further comprising:

receiving, via a controller operatively coupled to the one or more sensors, first pressure information within the blood vessel from the one or more sensors at a first time;

receiving, via the controller, second pressure information within the blood vessel from the one or more sensors at a second time while a distension mechanism applies a first force to the inner wall of the blood vessel sufficient to distend the blood vessel and stimulate baroreceptors within the blood vessel;

receiving, via the controller after ultrasonic energy is emitted within the blood vessel via the ultrasound transducer, third pressure information within the blood vessel from the one or more sensors at a third time while the distension mechanism applies a second force to the inner wall of the blood vessel sufficient to distend the blood vessel and stimulate baroreceptors within the blood vessel; and

comparing, via the controller, the second pressure information to the third pressure information to determine whether the ultrasonic energy has reduced neural activity of nerves around the blood vessel.

27 . The method of claim 26 , wherein the second pressure information is indicative of a first pressure gradient between pressure within the blood vessel while the first force is applied to the inner wall of the blood vessel and pre-distension pressure within the blood vessel associated with the first pressure information, wherein the third pressure information is indicative of a second pressure gradient between pressure within the blood vessel while the second force is applied to the inner wall of the blood vessel and pre-distension pressure within the blood vessel associated with the first pressure information, and wherein comparing the second pressure information to the third pressure information to determine whether the ultrasonic energy has reduced neural activity of nerves around the blood vessel comprises determining, via the controller, if the comparison of the second and third pressure information indicates that the second pressure gradient is less than the first pressure gradient by more than a predetermined threshold.

28 . The method of claim 26 , wherein the expandable metal anchor comprises the distension mechanism.

29 . The method of claim 21 , wherein the blood vessel is a pulmonary artery.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 3, 2023
From: AMAOUA, DAVID; GRASSE, MARTIN; CANNON, WILLIAM
To: GRADIENT DENERVATION TECHNOLOGIES SAS
Reel/Frame 064489/0100 →
Priority Claims (1)
EP 21305873 · Jun 24, 2021 · regional
Continuity (3)
Continuation 17935881 · Sep 27, 2022
Continuation PCTIB2022055854 · Jun 23, 2022
Related Publication 20230380895A1 · Nov 30, 2023
References Cited (302)
US 4869263A · Segal et al. · 1989 [cited by applicant]
US 4955377A · Lennox et al. · 1990 [cited by applicant]
US 5882329A · Patterson et al. · 1999 [cited by applicant]
US 6011995A · Guglielmi · 2000 [cited by examiner]
US 6117101A · Diederich et al. · 2000 [cited by applicant]
US 6217585B1 · Houser et al. · 2001 [cited by applicant]
US 6292695B1 · Webster, Jr. et al. · 2001 [cited by applicant]
US 6411852B1 · Danek et al. · 2002 [cited by applicant]
US 6493589B1 · Medhkour et al. · 2002 [cited by applicant]
US 6494835B1 · Ciezki et al. · 2002 [cited by applicant]
US 6564096B2 · Mest · 2003 [cited by applicant]
US 6669655B1 · Acker et al. · 2003 [cited by applicant]
US 6690971B2 · Schauerte et al. · 2004 [cited by applicant]
US 6763261B2 · Casscells, III et al. · 2004 [cited by applicant]
US 6763722B2 · Fjield et al. · 2004 [cited by applicant]
US 7090648B2 · Sackner et al. · 2006 [cited by applicant]
US 7260431B2 · Libbus et al. · 2007 [cited by applicant]
US 7269457B2 · Shafer et al. · 2007 [cited by applicant]
US 7363076B2 · Yun et al. · 2008 [cited by applicant]
US 7367951B2 · Bennett et al. · 2008 [cited by applicant]
US 7587238B2 · Moffitt et al. · 2009 [cited by applicant]
US 7616990B2 · Chavan et al. · 2009 [cited by applicant]
US 7623926B2 · Rossing et al. · 2009 [cited by applicant]
US 7630760B2 · Libbus et al. · 2009 [cited by applicant]
US 7664548B2 · Amurthur et al. · 2010 [cited by applicant]
US 7711430B2 · Errico et al. · 2010 [cited by applicant]
US 7715915B1 · Ryu et al. · 2010 [cited by applicant]
US 7734355B2 · Cohen et al. · 2010 [cited by applicant]
US 7744618B2 · Shuros et al. · 2010 [cited by applicant]
US 7783353B2 · Libbus et al. · 2010 [cited by applicant]
US 7801604B2 · Brockway et al. · 2010 [cited by applicant]
US 7826899B1 · Ryu et al. · 2010 [cited by applicant]
US 7828795B2 · Privitera et al. · 2010 [cited by applicant]
US 7899527B2 · Yun et al. · 2011 [cited by applicant]
US 7925342B2 · Amurthur et al. · 2011 [cited by applicant]
US 7937147B2 · Sih et al. · 2011 [cited by applicant]
US 8019435B2 · Hastings et al. · 2011 [cited by applicant]
US 8027724B2 · Wei et al. · 2011 [cited by applicant]
US 8052668B2 · Sih · 2011 [cited by applicant]
US 8073538B2 · Peters et al. · 2011 [cited by applicant]
US 8088127B2 · Mayse et al. · 2012 [cited by applicant]
US 8249705B1 · Kieval et al. · 2012 [cited by applicant]
US 8585601B2 · Sverdlik et al. · 2013 [cited by applicant]
US 8634921B2 · Chavan et al. · 2014 [cited by applicant]
US 8696581B2 · Sverdlik et al. · 2014 [cited by applicant]
US 8845629B2 · Demarais et al. · 2014 [cited by applicant]
US 8936027B2 · Santamore et al. · 2015 [cited by applicant]
US 8986342B2 · Naghavi et al. · 2015 [cited by applicant]
US 9005100B2 · Gnanashanmugam et al. · 2015 [cited by applicant]
US 9028391B2 · Gnanashanmugam et al. · 2015 [cited by applicant]
US 9028417B2 · Sverdlik et al. · 2015 [cited by applicant]
US 9179916B2 · Brenneman et al. · 2015 [cited by applicant]
US 9186198B2 · Demarais et al. · 2015 [cited by applicant]
US 9326786B2 · Sverdlik et al. · 2016 [cited by applicant]
US 9566456B2 · Sverdlik et al. · 2017 [cited by applicant]
US 9700372B2 · Schaer · 2017 [cited by applicant]
US 9707034B2 · Schaer · 2017 [cited by applicant]
US 9820800B2 · Chen · 2017 [cited by applicant]
US 9827036B2 · Chen · 2017 [cited by applicant]
US 9833623B2 · Gnanashanmugam et al. · 2017 [cited by applicant]
US 9839408B2 · Roschak et al. · 2017 [cited by applicant]
US 9872720B2 · Chen · 2018 [cited by applicant]
US 9918776B2 · Chen · 2018 [cited by applicant]
US 9943666B2 · Warnking · 2018 [cited by applicant]
US 9955970B2 · Brenneman et al. · 2018 [cited by applicant]
US 9981108B2 · Warnking · 2018 [cited by applicant]
US 10039901B2 · Warnking · 2018 [cited by applicant]
US 10223786B2 · Dickrell, III et al. · 2019 [cited by applicant]
US 10230041B2 · Taylor et al. · 2019 [cited by applicant]
US 10350440B2 · Taylor et al. · 2019 [cited by applicant]
US 10357304B2 · Sverdlik et al. · 2019 [cited by applicant]
US 10368893B2 · Sverdlik et al. · 2019 [cited by applicant]
US 10368944B2 · Schaer · 2019 [cited by applicant]
US 10456605B2 · Taylor et al. · 2019 [cited by applicant]
US 10499937B2 · Warnking · 2019 [cited by applicant]
US 10518112B2 · Gilad · 2019 [cited by applicant]
US 10568688B2 · Hu et al. · 2020 [cited by applicant]
US 10638786B2 · Barnes et al. · 2020 [cited by applicant]
US 10736692B2 · Pilcher et al. · 2020 [cited by applicant]
US 10842556B1 · Tandri et al. · 2020 [cited by applicant]
US 10874454B2 · Chen · 2020 [cited by applicant]
US 10893809B2 · Denney, Jr. et al. · 2021 [cited by applicant]
US 10933259B2 · Sverdlik et al. · 2021 [cited by applicant]
US 11007001B1 · Carignan et al. · 2021 [cited by applicant]
US 11241267B2 · Chen · 2022 [cited by applicant]
US 11318331B2 · Shabtay et al. · 2022 [cited by applicant]
US 11701171B2 · Schultheis et al. · 2023 [cited by applicant]
US 11950842B2 · Amaoua et al. · 2024 [cited by applicant]
US 20010031987A1 · Saksena et al. · 2001 [cited by applicant]
US 20030216792A1 · Levin et al. · 2003 [cited by applicant]
US 20040019349A1 · Fuimaono et al. · 2004 [cited by applicant]
US 20040082859A1 · Schaer · 2004 [cited by applicant]
US 20050251127A1 · Brosch et al. · 2005 [cited by applicant]
US 20050261672A1 · Deem et al. · 2005 [cited by applicant]
US 20050283148A1 · Janssen et al. · 2005 [cited by applicant]
US 20060041277A1 · Deem et al. · 2006 [cited by applicant]
US 20060052750A1 · Lenker et al. · 2006 [cited by applicant]
US 20060116737A1 · Libbus · 2006 [cited by applicant]
US 20060167498A1 · DiLorenzo · 2006 [cited by applicant]
US 20060217772A1 · Libbus et al. · 2006 [cited by applicant]
US 20060271151A1 · McGarry et al. · 2006 [cited by applicant]
US 20070129720A1 · Demarais et al. · 2007 [cited by applicant]
US 20070129760A1 · Demarais et al. · 2007 [cited by applicant]
US 20070142879A1 · Greenberg et al. · 2007 [cited by applicant]
US 20070191904A1 · Libbus et al. · 2007 [cited by applicant]
US 20070255379A1 · Williams et al. · 2007 [cited by applicant]
US 20080255642A1 · Zarins et al. · 2008 [cited by applicant]
US 20080306570A1 · Rezai et al. · 2008 [cited by applicant]
US 20090024124A1 · Lefler et al. · 2009 [cited by applicant]
US 20090062873A1 · Wu et al. · 2009 [cited by applicant]
US 20090118780A1 · DiLorenzo · 2009 [cited by applicant]
US 20090177262A1 · Oberti et al. · 2009 [cited by applicant]
US 20090216290A1 · Ruse et al. · 2009 [cited by applicant]
US 20090254142A1 · Edwards et al. · 2009 [cited by applicant]
US 20090264741A1 · Markowitz et al. · 2009 [cited by applicant]
US 20100094196A1 · Nash et al. · 2010 [cited by applicant]
US 20100113928A1 · Thapliyal et al. · 2010 [cited by applicant]
US 20100114095A1 · Janssen et al. · 2010 [cited by applicant]
US 20100137860A1 · Demarais et al. · 2010 [cited by applicant]
US 20100217347A1 · Swoyer et al. · 2010 [cited by applicant]
US 20100228317A1 · Libbus et al. · 2010 [cited by applicant]
US 20100241188A1 · Errico et al. · 2010 [cited by applicant]
US 20100249773A1 · Clark et al. · 2010 [cited by applicant]
US 20100249859A1 · DiLorenzo · 2010 [cited by applicant]
US 20100268307A1 · Demarais et al. · 2010 [cited by applicant]
US 20100274221A1 · Sigg et al. · 2010 [cited by applicant]
US 20100286684A1 · Hata et al. · 2010 [cited by applicant]
US 20100286734A1 · Yun et al. · 2010 [cited by applicant]
US 20100298905A1 · Simon · 2010 [cited by applicant]
US 20110118725A1 · Mayse et al. · 2011 [cited by applicant]
US 20110152855A1 · Mayse et al. · 2011 [cited by applicant]
US 20110178569A1 · Parnis et al. · 2011 [cited by applicant]
US 20110200171A1 · Beetel et al. · 2011 [cited by applicant]
US 20110202098A1 · Demarais et al. · 2011 [cited by applicant]
US 20110207758A1 · Sobotka et al. · 2011 [cited by applicant]
US 20110257523A1 · Hastings et al. · 2011 [cited by applicant]
US 20110257708A1 · Kramer et al. · 2011 [cited by applicant]
US 20110276103A1 · Maile et al. · 2011 [cited by applicant]
US 20110301587A1 · Deem et al. · 2011 [cited by applicant]
US 20110301679A1 · Rezai et al. · 2011 [cited by applicant]
US 20120029500A1 · Jenson · 2012 [cited by applicant]
US 20120029505A1 · Jenson · 2012 [cited by applicant]
US 20120029509A1 · Smith · 2012 [cited by applicant]
US 20120029510A1 · Haverkost · 2012 [cited by applicant]
US 20120029511A1 · Smith et al. · 2012 [cited by applicant]
US 20120029512A1 · Willard et al. · 2012 [cited by applicant]
US 20120065554A1 · Pikus · 2012 [cited by applicant]
US 20120123258A1 · Willard · 2012 [cited by applicant]
US 20120123406A1 · Edmunds et al. · 2012 [cited by applicant]
US 20120143097A1 · Pike, Jr. · 2012 [cited by applicant]
US 20120143294A1 · Clark et al. · 2012 [cited by applicant]
US 20120157992A1 · Smith et al. · 2012 [cited by applicant]
US 20120157993A1 · Jenson et al. · 2012 [cited by applicant]
US 20120158104A1 · Huynh et al. · 2012 [cited by applicant]
US 20120165815A1 · Collins et al. · 2012 [cited by applicant]
US 20120172680A1 · Gelfand et al. · 2012 [cited by applicant]
US 20120172723A1 · Gertner · 2012 [cited by applicant]
US 20120172870A1 · Jenson et al. · 2012 [cited by applicant]
US 20120184952A1 · Jenson et al. · 2012 [cited by applicant]
US 20120232551A1 · Swanson et al. · 2012 [cited by applicant]
US 20120265227A1 · Sverdlik et al. · 2012 [cited by applicant]
US 20120277839A1 · Kramer et al. · 2012 [cited by applicant]
US 20120290024A1 · Zhang et al. · 2012 [cited by applicant]
US 20120294424A1 · Chin et al. · 2012 [cited by applicant]
US 20120302909A1 · Mayse et al. · 2012 [cited by applicant]
US 20130053792A1 · Fischell et al. · 2013 [cited by applicant]
US 20130204068A1 · Gnanashanmugam et al. · 2013 [cited by applicant]
US 20130204242A1 · Sverdlik et al. · 2013 [cited by applicant]
US 20130304062A1 · Chan et al. · 2013 [cited by applicant]
US 20130310829A1 · Cohen · 2013 [cited by applicant]
US 20140005706A1 · Gelfand et al. · 2014 [cited by applicant]
US 20140012133A1 · Sverdlik et al. · 2014 [cited by applicant]
US 20140025069A1 · Willard · 2014 [cited by examiner]
US 20140031785A1 · Schwagten et al. · 2014 [cited by applicant]
US 20140058294A1 · Gross et al. · 2014 [cited by applicant]
US 20140163540A1 · Iyer et al. · 2014 [cited by applicant]
US 20140180227A1 · Robinson et al. · 2014 [cited by applicant]
US 20140180277A1 · Chen · 2014 [cited by applicant]
US 20140221975A1 · Gnanashanmugam et al. · 2014 [cited by applicant]
US 20140243809A1 · Gelfand et al. · 2014 [cited by applicant]
US 20140276714A1 · Edmunds et al. · 2014 [cited by applicant]
US 20140277033A1 · Taylor et al. · 2014 [cited by applicant]
US 20140316269A1 · Zhang et al. · 2014 [cited by applicant]
US 20140358140A1 · Emmons et al. · 2014 [cited by applicant]
US 20150057599A1 · Chen · 2015 [cited by applicant]
US 20150105715A1 · Pikus et al. · 2015 [cited by applicant]
US 20150141810A1 · Weadock · 2015 [cited by applicant]
US 20150165244A1 · Kardosh et al. · 2015 [cited by applicant]
US 20150256592A1 · Young et al. · 2015 [cited by applicant]
US 20150257779A1 · Sinelnikov et al. · 2015 [cited by applicant]
US 20150272666A1 · Wang · 2015 [cited by applicant]
US 20150290427A1 · Warnking · 2015 [cited by examiner]
US 20160008058A1 · Hu et al. · 2016 [cited by applicant]
US 20160016016A1 · Taylor · 2016 [cited by examiner]
US 20160113699A1 · Sverdlik et al. · 2016 [cited by applicant]
US 20160220851A1 · Mayse et al. · 2016 [cited by applicant]
US 20160262777A1 · Stigall et al. · 2016 [cited by applicant]
US 20160302857A1 · Rothman et al. · 2016 [cited by applicant]
US 20160303381A1 · Pierce · 2016 [cited by examiner]
US 20160317621A1 · Bright · 2016 [cited by applicant]
US 20170071664A1 · Lim · 2017 [cited by examiner]
US 20170216032A1 · Van Bladel et al. · 2017 [cited by applicant]
US 20170348049A1 · Vrba et al. · 2017 [cited by applicant]
US 20170354461A1 · Rothman et al. · 2017 [cited by applicant]
US 20180140347A1 · Chen · 2018 [cited by applicant]
US 20180326227A1 · Sverdlik et al. · 2018 [cited by applicant]
US 20180360531A1 · Holmes, Jr. et al. · 2018 [cited by applicant]
US 20190104933A1 · Stern et al. · 2019 [cited by applicant]
US 20190105104A1 · Bertolero et al. · 2019 [cited by applicant]
US 20190183372A1 · Ruppersberg · 2019 [cited by applicant]
US 20190224484A1 · Pierce · 2019 [cited by examiner]
US 20190290350A1 · Sverdlik et al. · 2019 [cited by applicant]
US 20190308003A1 · Sverdlik et al. · 2019 [cited by applicant]
US 20190343579A1 · Tandri et al. · 2019 [cited by applicant]
US 20190366130A1 · Sverdlik et al. · 2019 [cited by applicant]
US 20200038638A1 · Gliner · 2020 [cited by applicant]
US 20200094080A1 · Shabtay et al. · 2020 [cited by applicant]
US 20200101270A1 · Sutherland · 2020 [cited by applicant]
US 20200101328A1 · Gilad · 2020 [cited by applicant]
US 20200146562A1 · Chronos et al. · 2020 [cited by applicant]
US 20200179045A1 · Levin et al. · 2020 [cited by applicant]
US 20200238107A1 · Shabtay et al. · 2020 [cited by applicant]
US 20200305952A1 · Sharma et al. · 2020 [cited by applicant]
US 20200368244A1 · Shabtay et al. · 2020 [cited by applicant]
US 20210178194A1 · Sverdlik et al. · 2021 [cited by applicant]
US 20210267680A1 · Sela et al. · 2021 [cited by applicant]
US 20210338305A1 · Chen · 2021 [cited by applicant]
AU 2007290727A1 · 2008 [cited by applicant]
EP 0467422A2 · 1992 [cited by applicant]
EP 1182980A1 · 2002 [cited by applicant]
EP 1637086A1 · 2006 [cited by applicant]
EP 2999411A2 · 2016 [cited by applicant]
RU 2074645C1 · 1997 [cited by applicant]
RU 2102090C1 · 1998 [cited by applicant]
SU 1119663A1 · 1984 [cited by applicant]
SU 1412745A1 · 1988 [cited by applicant]
SU 1734708A1 · 1992 [cited by applicant]
WO WO9301862A1 · 1993 [cited by applicant]
WO WO9965561A1 · 1999 [cited by applicant]
WO WO2007078997A2 · 2007 [cited by applicant]
WO WO2010110785A1 · 2010 [cited by applicant]
WO WO2011075328A1 · 2011 [cited by applicant]
WO WO2011091069A1 · 2011 [cited by applicant]
WO WO2012068268A2 · 2012 [cited by applicant]
WO WO2012120495A2 · 2012 [cited by applicant]
WO WO2012149341A1 · 2012 [cited by applicant]
WO WO2012149511A2 · 2012 [cited by applicant]
WO WO2012154800A1 · 2012 [cited by applicant]
WO WO2013090848A1 · 2013 [cited by applicant]
WO WO2015089505A2 · 2015 [cited by examiner]
WO WO2015102951A2 · 2015 [cited by applicant]
WO WO2016007851A1 · 2016 [cited by applicant]
WO WO2017156039A1 · 2017 [cited by examiner]
WO WO2019148094A1 · 2019 [cited by applicant]
WO WO2020039442A1 · 2020 [cited by examiner]
WO WO2020091125A1 · 2020 [cited by applicant]
Osorio et al., “Reflex Changes on the Pulmonary and Systemic Pressures Elicited by Stimulation of Baroreceptors in the Pulmonary Artery”, Circulation Research, vol. X, pp. 664-667 (Year: 1962). [cited by examiner]
ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension, J. Am. Coll. Cardiology, 53(17):1573-1619 (Apr. 2009). [cited by applicant]
Banasiak, et al., Normalization of pulmonary hypertension after experimental pulmonary denervation therapy and MitraClip implantation in a patient initially disqualified from heart transplant, Kardiologia Polska (Polish… [cited by applicant]
Brace; Radiofrequency and Microwave Ablation of the Liver . . . ; National Institute of Health/NIH Public Access Author Manuscript; Curr Probl Diagn Radiol., 38(3); pp. 135-143, doi:10.1067, 2009. [cited by applicant]
Breitling, et al., The pathophysiology of pulmonary hypertension in left heart disease, Am. J. Physiol. Lung Cell Mol. Physiol, 309:L924-L941 (Aug. 2015). [cited by applicant]
Chen, et al., Pulmonary Artery Denervation: An Alternative Therapy for Pulmonary Hypertension, J. Am. Coll. Cardiol. Intv., 12(7):691-692 (Apr. 2019). [cited by applicant]
Chernyavskiy, et al., Radiofrequency Pulmonary Artery Ablation For Treatment of Residual Pulmonary Hypertension After Pulmonary Endarterectomy, Kardiologiia, 4:15-21 (Apr. 2018). [cited by applicant]
Constantine, et al., Pulmonary artery denervation for pulmonary arterial hypertension, Trends in Cardiovascular Medicine, 31(4):252-260 (May 2021). [cited by applicant]
Cruz et al., Cardiopulmonary Effects Following Endoscopic Thoracic Sympathectom. ; European Journal of Cardio-Toracic Surgery, pp. 491-496, Elsevier B.V., 2009. [cited by applicant]
Dimopoulos, et al., Pulmonary Artery Denervation: A New, Long-Awaited Interventional Treatment for Combined Pre- and Post-Capillary Pulmonary Hypertension?, J. Am. Coll. Cardiol. Cardiovasc. Interv., 12(3):285-288 (Feb.… [cited by applicant]
Domingo, et al., Reproducibility Of In Vivo Pulmonary Arterial Remodeling Assessment In Stable Pulmonary Arterial Hypertension, J. Am. Coll. Cardiol., 73(9S1):1937 (Mar. 2019). [cited by applicant]
Ernst, et al., Anatomy of the Pericardial Space and Mediastinum: Relevance to Epicardial Mapping and Ablation, Cardiac Electrophysiology Clinics, 2(1):1-8 (Mar. 2010). [cited by applicant]
Ferguson et al., “Effect of Lung Denervation on Pulmonary Hypertension and Edema”, Circulation Research, vol. V, pp. 310-314, 1957. [cited by applicant]
Feshchenko, et al., Cryoablation method for pulmonary artery sympathetic denervation in patients with pulmonary hypertension secondary to left sided heart disease: interventional technique, safety and results of the hos… [cited by applicant]
Flues et al., “Cardiac and pulmonary arterial remodeling after sinoaortic denervation in normotensive rates,” Autonomic Neuroscience: Basic and Clinical, vol. 166, Issue 1-2, pp. 47-53, 2012. [cited by applicant]
Garcia-Lunar, et al., Effect of pulmonary artery denervation in postcapillary pulmonary hypertension: results of a randomized controlled study, Basic Research in Cardiology, 114(2):5 (Mar. 2019). [cited by applicant]
Garutti et al., Surgical Upper Thoracic Sympathectomy Reduces Arterial Oxygenation . . . , Letters to the Editor, p. 703-4, doi; 10.1053/j.jvca.2004.12.008, 2005. [cited by applicant]
Goncharova, et al., Electrical Stimulation-Guided Approach to Pulmonary Artery Catheter Ablation in Patients With Idiopathic Pulmonary Arterial Hypertension: A Pilot Feasibility Study with a 12-Month Follow-Up, BioMed R… [cited by applicant]
Huang, et al., Transthoracic Pulmonary Artery Denervation for Pulmonary Arterial Hypertension, Arteriosclerosis, Thrombosis, and Vascular Biology, 39(4):704-718 (Apr. 2019). [cited by applicant]
Hyman, A., Pulmonary Vasoconstriction Due to Nonocclusive Distention of Large Pulmonary Arteries in the Dog, Circulation Research, 23(3):401-413 (Sep. 1968). [cited by applicant]
International Search Report & Written Opinion dated Jan. 2, 2023 in Int'l PCT Patent Appl. Serial No. PCT/IB2022/055854 (0210). [cited by applicant]
Jiang, et al., Sympathetic innervation of canine pulmonary artery and morphometric and functional analysis in dehydromonocrotaline-induced models after pulmonary artery denervation, Interactive CardioVascular and Thorac… [cited by applicant]
Juratsch, et al., Pulmonary Arterial Hypertension Induced by Distention of the Main Pulmonary Artery in Conscious Newborn, Young, and Adult Sleep, Pediatric Research, 14(12):1332-1338 (Dec. 1980). [cited by applicant]
Kim, et al., Pulmonary Artery Denervation as an Innovative Treatment for Pulmonary Hypertension With and Without Heart Failure, Cardiology in Review, 29(2):89-95 (Mar. 2021). [cited by applicant]
Klinger and Frantz, Respiratory Medicine—Diagnosis and Management of Pulmonary Hypertension, Humana Press, 2015. [cited by applicant]
Le, et al., Pulmonary artery denervation: a novel treatment modality for pulmonary hypertension, J. Thorac. Dis., 11(4):1094-1096 (Apr. 2019). [cited by applicant]
Leandro, et al., Stimulation mapping of the pulmonary artery for denervation procedures: an experimental study, Journal of Cardiovascular Translational Research, 14(3):546-555 (Jun. 2021). [cited by applicant]
Naeije et al., “Pulmonary vascular responses to surgical chemodenervation and chemical sympathectomy in dogs,” American Physiological Society, pp. 42-50, 1989. [cited by applicant]
Ntiloudi, et al., Pulmonary arterial hypertension: the case for a bioelectronic treatment, Bioelectronic Medicine, 5(1):1-3 (Dec. 2019). [cited by applicant]
Ogo, T., Transthoracic Pulmonary Artery Denervation: New Insight Into Autonomic Nervous System in Pulmonary Arterial Hypertension, Arteriosclerosis, Thrombosis, and Vascular Biology, 39(6):979-981 (May 2019). [cited by applicant]
Osorio, et al., Reflex Changes on the Pulmonary and Systemic Pressures Elicited by Stimulation of Baroreceptors in the Pulmonary Artery, Circulation Research, 10(4):664-667 (1962). [cited by applicant]
Osorio, et al., Reflex Changes on the Pulmonary and Systemic Pressures Elicited by Stimulation of Baroreceptors in the Pulmonary Artery, Circulation Research, 10(4):664-667 (Apr. 1962). [cited by applicant]
Oswald-Mammosser, et al., Prognostic Factors in COPD Patients Receiving Long-term Oxygen Therapy—Importance of Pulmonary Artery Pressure, Chest, 107(5):1193-1198 (May 1995). [cited by applicant]
Pritzker, M., Zapping the Pulmonary Artery Nerves, Cardiovascular Interventions, 13(8):1000-2 (Apr. 2020). [cited by applicant]
Razee, et al., Pulmonary Artery Denervation for Pulmonary Hypertension: Recent Updates and Future Perspectives, Trends in Cardiovascular Medicine, 31(4):261-263 (May 2021). [cited by applicant]
Redfield, et al., Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial, JAMA, 309(12):1268-1277 (Mar. 2013). [cited by applicant]
Romanov, et al., Pulmonary Artery Denervation for Patients With Residual Pulmonary Hypertension After Pulmonary Endarterectomy, Journal of the American College of Cardiology, 76(8):916-926 (Aug. 2020). [cited by applicant]
Rothman, et al., Intravascular Ultrasound Pulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension (TROPHY1): Multicenter, Early Feasibility Study, JACC: Cardiovascular Interventions, 13(8):989-999 (Apr. 20… [cited by applicant]
Savarese, et al., Global Public Health Burden of Heart Failure, Cardiac Failure Review, 3(1):7 (Apr. 2017). [cited by applicant]
Stone, M.D., Gregg, Pulmonary Artery Denervation (PADN): An Emerging Treatment For Pulmonary Hypertension, Mount Sinai School of Medicine and the Cardiovascular Research Foundation, 2021. [cited by applicant]
Tendolkar, et al., Review of Advances in Management of Pulmonary Hypertension, Journal of Marine Medical Society, 21(1):9 (Jan. 2019). [cited by applicant]
Trofimov, et al., Denervation of Pulmonary Arteries in Patients With Mitral Valve Defects Complicated by Atrial Fibrillation and Pulmonary Hypertension, , 11(4 (eng)):95-103 (2019). [cited by applicant]
Yaylali, et al., Will Pulmonary Artery Denervation Really Have a Place in the Armamentarium of the Pulmonary Hypertension Specialist?, J. Am. Coll. Cardiol. Intv., 12(8):799-800 (Apr. 2019). [cited by applicant]
Zhang, et al., Pulmonary artery denervation improves hemodynamics and cardiac function in pulmonary hypertension secondary to heart failure, Pulmonary Circulation, 9(2):1-12 (Jul. 2019). [cited by applicant]
Zhang, et al., Pulmonary Artery Denervation Significantly Increases 6-Min Walk Distance for Patients With Combined Pre- and Post-Capillary Pulmonary Hypertension Associated With Left Heart Failure: The PADN-5 Study, Jac… [cited by applicant]
Extended EP Search Report & Opinion dated Sep. 4, 2024 in EP Patent Appl. No. 24178336.4. [cited by applicant]