Granted Patent B2

US 12,539,160 · App. 16/439,816 · Granted Feb 3, 2026

Inventors: Ariel Sverdlik (Tel-Aviv, IL); Yehuda Zadok (Holon, IL); Or Shabtay (Kibbutz Farod, IL); Iris Szwarcfiter (Tel-Aviv, IL); Avital Schauder (Lod, IL); Krishna J. Rocha-Singh (Springfield, IL)

Assignee: Sonivie Ltd.

A61B18/082A61N7/022A61B2018/00375A61B2018/00404A61B2018/00434A61B2018/00511A61B2018/00577A61B2018/00636A61N2007/003A61N2007/0052A61N2007/0078A61N2007/027

Abstract

Claims (17)

1 . A method of treating nerve tissue, comprising:

inserting a catheter including an ultrasound emission element into a lumen of a blood vessel having a wall that has plaque or calcification;

positioning said catheter at one or more spaced apart locations along said blood vessel lumen where plaque or the calcification exist;

selectively applying unfocused ultrasound energy in a form of one or more pencil beams from within said blood vessel lumen and through said plaque or calcification to form one or more spaced apart regions of thermal damage in the nerve tissue located outside said blood vessel lumen by said unfocused ultrasound energy in the form of the one or more pencil beams;

continuing said applying, without causing rupture of said plaque or calcification, until said one or more spaced apart regions of thermal damage is obtained,

wherein said positioning comprises selecting said one or more spaced apart locations with knowledge that the plaque or the calcification exist thereat.

2 . The method according to claim 1 , comprising spacing apart a head of said catheter from said blood vessel wall so that blood flow along said wall is not blocked by said catheter.

3 . The method according to claim 1 , comprising positioning a head of said catheter at a distance of at least 1 mm from said wall such that said head does not contact said plaque or calcification.

4 . The method according to claim 1 , wherein said one or more spaced apart regions of thermal damage are formed at about 0.5 mm-10 mm from an intima of said blood vessel lumen.

5 . The method according to claim 1 , comprising applying force against the blood vessel lumen wall which is sufficient to maintain said blood vessel lumen open.

6 . The method according to claim 1 , comprising determining the presence of the plaque or the calcification in said blood vessel prior to said inserting or to said positioning.

7 . The method according to claim 6 , wherein determining said presence of plaque or calcification is via ultrasound.

8 . The method according to claim 1 , wherein selectively applying the unfocused ultrasound energy is for a duration of between 5 to 180 seconds.

9 . The method of claim 1 , wherein said ultrasound emission element comprises a planar emitting surface configured to emit said unfocused one or more pencil beams of unfocused ultrasound energy.

10 . The method according to claim 1 , wherein said unfocused ultrasound energy in the form of the one or more pencil beams has a frequency and an intensity suitable for generating said one or more spaced apart regions of thermal damage in said nerve tissue located outside said blood vessel lumen, and

wherein said intensity is between 20 Watt/cm{circumflex over ( )}2 to 50 Watt/cm{circumflex over ( )}2.

11 . The method according to claim 10 , wherein said frequency is between 10 MHz and 40 MHz.

Assignments (2)

Continuity (3)

References Cited (400)