Catheter guidance of external energy for renal denervation
An in vivo apparatus includes a flexible shaft having a proximal end, a distal end, and a length sufficient to access a patient's renal artery relative to a percutaneous access location. An energy guide apparatus is provided at the distal end of the shaft and dimensioned for deployment within the renal artery. An ex vivo apparatus includes an arrangement configured to localize the energy guide apparatus within the renal artery, and an energy source configured to direct ablative energy to target tissue located a predetermined distance from the localized energy guide apparatus. The target tissue includes perivascular renal nerve tissue adjacent the renal artery.
1. An apparatus, comprising:
an in vivo apparatus comprising:
a flexible shaft having a proximal end a distal end; and
an energy guide apparatus provided at the distal end of the shaft and configured to generate a rotating energy beacon including a rotating magnetic field and a rotating beam of acoustic energy;
an ex vivo apparatus comprising:
a localizing arrangement configured to localize the energy guide apparatus within a renal artery, wherein the localizing arrangement is configured to:
sense the rotating magnetic field;
detect the rotating beam of acoustic energy; and
localize the energy guide apparatus using at least the sensed rotating magnetic field and the detected rotating beam of acoustic energy; and
an energy source configured to direct ablative energy to a position that is adjacent to and offset from the localized energy guide apparatus;
wherein the localizing arrangement comprises an array of ultrasound transducers configured to receive the rotating beam of acoustic energy and operable in a low-intensity imaging mode to generate an image of the energy guide apparatus; and
wherein the localizing arrangement is configured to localize the energy guide apparatus within the renal artery using at least the generated image.