Methods for monitoring renal neuromodulation
Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
1. A method for monitoring renal neuromodulation, the method comprising:
applying a stimulation electric field to a tissue;
monitoring a physiologic response to the stimulation electric field indicating in the tissue the presence of a neural fiber that innervates a kidney; and
inhibiting neural activity along the neural fiber in a minimally invasive manner,
wherein inhibiting neural activity along the neural fiber comprises applying a denervating electric field to the neural fiber via an intravascularly positioned catheter.
2. The method of claim 1 wherein applying a stimulation field and monitoring a physiologic response comprise applying a stimulation field and monitoring a first physiologic response prior to applying a denervating electric field and applying a stimulation field and monitoring a second physiologic response after applying a denervating electric field.
3. The method of claim 2 further comprising comparing the first physiologic response and the second physiologic response to determine an extent of renal neuromodulation.
4. The method of claim 1 wherein applying a denervating electric field comprises ablating the neural fiber.
5. The method of claim 1 wherein applying a stimulation electric field comprises stimulating afferent renal nerve fibers.
6. The method of claim 1 wherein applying a stimulation electric field comprises stimulating efferent renal nerve fibers.
7. The method of claim 1 wherein applying a stimulation electric field comprises intravascularly delivering the stimulation electric field.
8. The method of claim 7 wherein applying a stimulation electric field further comprises modulating at least one of frequency, amplitude and pulse duration of the stimulation electric field to facilitate passage of the electric field to the tissue.
9. The method of claim 1 wherein monitoring a physiologic response to the stimulation electric field comprises monitoring at least one of renin, sodium, and blood pressure.
10. The method of claim 1 wherein monitoring a physiologic response to the stimulation electric field comprises monitoring a reduction in renal blood flow.
11. The method of claim 1 , further comprising identifying an optimal location for renal neuromodulation based on the monitored physiologic parameter.
12. The method of claim 1 wherein the stimulation field is a first stimulation field, and wherein the method further comprises applying a second stimulation field to the tissue and monitoring the absence of a physiologic response following inhibiting neural activity along the neural fiber.
13. A method for monitoring effectiveness of renal neuromodulation, the method comprising:
applying a stimulation electric field to renal nerves;
monitoring a change in renal blood flow in response to the stimulation electric field; and
delivering an energy field to the renal nerves via an intravascularly positioned catheter, wherein the energy field inhibits neural activity along the renal nerves.
14. The method of claim 13 wherein monitoring a change in renal blood flow comprises monitoring the velocity of blood flow through the renal artery.
15. The method of claim 14 wherein monitoring the velocity of blood flow through the renal artery comprises monitoring blood flow velocity using a Doppler ultrasound sensor.
16. The method of claim 13 wherein monitoring a change in renal blood flow comprises monitoring the flowrate of blood flow through the renal artery.
17. The method of claim 16 wherein monitoring a change in renal blood flow further comprises monitoring the flowrate prior to stimulation to determine a baseline flowrate, monitoring the flowrate after stimulation and comparing the flowrate after stimulation to the baseline flowrate.
18. The method of claim 13 wherein monitoring a change in renal blood flow comprises visually monitoring a change in renal blood flow.
19. The method of claim 18 wherein visually monitoring a change in renal blood flow comprises visualizing renal blood flow using an external ultrasound transducer.
20. The method of claim 13 wherein monitoring a change in renal blood flow comprises monitoring renal blood flow via a pressure transducer.
21. The method of claim 13 wherein monitoring a change in renal blood flow comprises measuring travel time lag of an intravascular temperature input.
22. The method of claim 13 wherein delivering an energy field to the renal nerves comprises ablating the renal nerves via the energy field.