IP Library Granted Patent US 10,086,352
Granted Patent B2
US 10,086,352 · App. 15/229,105 · Granted Oct 2, 2018

Conversion of nitrogen dioxide (NO

Inventors: David H. Fine (Cocoa Beach, FL); David R. Rounbehler (Las Cruces, NM); Gregory Vasquez (Cocoa, FL); Brian Johnson (Orlando, FL)
Assignee: VERO BIOTECH LLC
B01J12/007A61K33/00A61M16/10A62B7/08C01B21/24
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Quick Facts
Patent No.
US 10,086,352
App. No.
15/229,105
Granted
Oct 2, 2018
Kind
B2
Abstract

A nitric oxide delivery system, which includes a gas bottle having nitrogen dioxide in air, converts nitrogen dioxide to nitric oxide and employs a surface-active material, such as silica gel, coated with an aqueous solution of antioxidant, such as ascorbic acid. A nitric oxide delivery system may be used to generate therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal.

Claims (13)

1. A system for generating a therapeutic gas including nitric oxide for use in delivering the therapeutic gas to a mammal comprising:

a pressure regulator diffusing gaseous nitrogen dioxide into an air flow wherein the air flow is configured to be between 5 to 60 liters per minute;

a receptacle configured to attach to the pressure regulator, the receptacle including an inlet, an outlet, and a surface-active material coated with an aqueous solution of an antioxidant, wherein the inlet is configured to receive the air flow and fluidly communicate the flow to the outlet through the surface-active material to convert the gaseous nitrogen dioxide to nitric oxide at ambient temperature.

2. The system of claim 1 , wherein the air flow is at 5 liters per minute.

3. The system of claim 2 , wherein the receptacle has a pressure drop of between 0.001 and 0.01 psi.

4. The system of claim 1 , wherein the air flow is at 60 liters per minute or lower.

5. The system of claim 4 , wherein the receptacle has a pressure drop of between 0.001 and 0.05 psi.

6. The system of claim 1 , wherein the receptacle comprises a cartridge.

7. The system of claim 1 , wherein the surface-active material is saturated with the aqueous solution of the antioxidant.

8. The system of claim 1 , wherein the surface-active material comprises a substrate that retains water.

9. The system of claim 1 , wherein the surface-active material comprises a silica gel.

10. The system of claim 1 , wherein the antioxidant comprises ascorbic acid.

11. The system of claim 1 , wherein the antioxidant comprises alpha tocopherol or gamma tocopherol.

Assignments (8)
RELEASE OF SECURITY INTEREST Recorded Mar 18, 2026
From: HORIZON TECHNOLOGY FINANCE CORPORATION
To: VERO BIOTECH INC.
Reel/Frame 075308/0198 →
SECURITY INTEREST Recorded Mar 16, 2026
From: VERO BIOTECH INC.
To: SYMBIOTIC CAPITAL AGENCY LLC, AS COLLATERAL AGENT
Reel/Frame 075117/0935 →
TERMINATION AND RELEASE OF INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Jan 3, 2024
From: RUNWAY GROWTH FINANCE CORP (F/K/A RUNWAY GROWTH CREDIT FUND INC.)
To: VERO BIOTECH INC. (F/K/A VERO BIOTECH LLC)
Reel/Frame 066186/0611 →
SECURITY INTEREST Recorded Jan 3, 2024
From: VERO BIOTECH INC.
To: HORIZON TECHNOLOGY FINANCE CORPORATION
Reel/Frame 066187/0865 →
CHANGE OF NAME Recorded Feb 14, 2022
From: VERO BIOTECH LLC
To: VERO BIOTECH INC.
Reel/Frame 059085/0418 →
SECURITY INTEREST Recorded Dec 29, 2020
From: VERO BIOTECH LLC
To: RUNWAY GROWTH CREDIT FUND INC.
Reel/Frame 054866/0589 →
CHANGE OF NAME Recorded Aug 7, 2018
From: GENO LLC
To: VERO BIOTECH LLC
Reel/Frame 048173/0247 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 3, 2016
From: FINE, DAVID H.; ROUNBEHLER, DAVID P.; VASQUEZ, GREGORY; JOHNSON, BRYAN
To: GENO LLC
Reel/Frame 040211/0958 →
Continuity (5)
Continuation 14270260 · May 5, 2014
Continuation 13436018 · Mar 30, 2012
Continuation 12563662 · Sep 21, 2009
Provisional Application 61098974 · Sep 22, 2008
Related Publication 20170182471A1 · Jun 29, 2017
Cited By (5)
US 12,509,349 US 12,522,501 US 12,569,628 US 12,576,234 US 12,606,436