Combination therapy
Described herein are compounds and compositions for treating glaucoma and/or reducing intraocular pressure. Compositions may comprise an isoquinoline compound and a prostaglandin or a prostaglandin analog. Compounds described herein include those in which an isoquinoline compound is covalently linked to a prostaglandin or a prostaglandin analog, and those in which an isoquinoline compound and a prostaglandin free acid together form a salt.
1. A composition comprising a dimesylate salt of (R)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate.
2. The composition of claim 1 , further comprising at least one of a buffer, a chelating agent, a tonicity agent, a preservative, a viscosity enhancer, a sugar, a sugar alcohol, or a surfactant.
3. A method of treating an ocular disorder in a subject in need thereof, comprising administering to the subject the composition of claim 1 .
4. The method of claim 3 , wherein the ocular disorder is glaucoma.
5. The method of claim 3 , wherein the composition is administered topically to an eye of the subject.
6. A method of reducing intraocular pressure in a subject in need thereof, comprising administering to the subject the composition of claim 1 .
7. The method of claim 6 , wherein the composition is administered topically to an eye of the subject.
8. A composition comprising a dimesylate salt of (S)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate.
9. The composition of claim 8 , further comprising at least one of a buffer, a chelating agent, a tonicity agent, a preservative, a viscosity enhancer, a sugar, a sugar alcohol, or a surfactant.
10. A method of treating an ocular disorder in a subject in need thereof, comprising administering to the subject the composition of claim 8 .
11. The method of claim 10 , wherein the ocular disorder is glaucoma.
12. The method of claim 10 , wherein the composition is administered topically to an eye of the subject.
13. A method of reducing intraocular pressure in a subject in need thereof, comprising administering to the subject the composition of claim 8 .
14. The method of claim 13 , wherein the composition is administered topically to an eye of the subject.
15. A composition comprising a dimesylate salt of (rac)-4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate.
16. The composition of claim 15 , further comprising at least one of a buffer, a chelating agent, a tonicity agent, a preservative, a viscosity enhancer, a sugar, a sugar alcohol, or a surfactant.
17. A method of treating an ocular disorder in a subject in need thereof, comprising administering to the subject the composition of claim 15 .
18. The method of claim 17 , wherein the ocular disorder is glaucoma.
19. The method of claim 17 , wherein the composition is administered topically to an eye of the subject.
20. A method of reducing intraocular pressure in a subject in need thereof, comprising administering to the subject the composition of claim 15 .
21. The method of claim 20 , wherein the composition is administered topically to an eye of the subject.