Bicyclic analgesic compounds
Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.
1. A compound of Formula 1:
wherein
R 1 is H, —CH 3 , CF 3 , or a substituted or unsubstituted (C 2 to C 5 ) lower alkyl;
R 2 is C(═Y)R 4 ;
R 3 is (C 1 to C 30 ) substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkynyl, heterocycle, heteroaryl, arylalkyl, alkylaryl or heteroarylalkyl;
R 4 is (C 1 to C 10 ) substituted or unsubstituted lower alkyl; and
Y is O.
2. The compound of claim 1 , wherein R 1 is H.
3. The compound of claim 1 , wherein R 1 is —CH 3 .
4. The compound of claim 1 , wherein R 2 is C(═Y)R 4 .
5. The compound of claim 1 , wherein R 3 is (C 1 to C 30 ) substituted alkyl.
6. The compound of claim 1 , wherein R 3 is (C 1 to C 30 ) unsubstituted alkyl.
7. The compound of claim 1 , wherein R 3 is alkenyl.
8. The compound of claim 1 , wherein R 3 is cycloalkyl.
9. The compound of claim 1 , wherein R 3 is cycloalkenyl.
10. The compound of claim 1 , wherein R 3 is heterocycle.
11. The compound of claim 1 , wherein R 3 is heteroaryl.
12. The compound of claim 1 , wherein R 3 is arylalkyl.
13. The compound of claim 1 , wherein R 3 is heteroarylalkyl.