IP Library Granted Patent US 9,924,863
Granted Patent B2
US 9,924,863 · App. 15/246,578 · Granted Mar 27, 2018

Optical coherence tomography systems integrated with surgical microscopes

Inventors: Eric L. Buckland (Hickory, NC); Nestor O. Farmiga (Rochester, NY); Robert H. Hart (Cary, NC); Andrew Murnan (Saratoga Springs, NY); Christopher Saxer (Chapel Hill, NC)
Assignee: Bioptigen, Inc.
A61B3/102A61B3/13A61B3/132G01B9/02039G01B9/02091G02B21/006G02B21/0012G02B21/0048G02B21/02G02B21/025G02B27/0031G02B27/0955G02B27/141A61B5/0066G02B1/11
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Quick Facts
Patent No.
US 9,924,863
App. No.
15/246,578
Granted
Mar 27, 2018
Kind
B2
Abstract

Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls for numerical aperture and focal position of the imaged OCT beam.

Claims (41)

1. An optical coherence tomography (OCT) system for integration with a stereo microscope, the OCT system comprising:

a sample arm coupled to an imaging path of a stereo microscope, the sample arm comprising:

an input beam zoom assembly including at least one movable lens configured to provide shape control for an OCT signal beam;

a scan assembly following the input beam zoom assembly including at least one scanning mirror and configured for scanning of the OCT signal beam; and

relay optics following the scan assembly including a beam expander configured to set an OCT signal beam diameter incident on a main objective of the stereo microscope; and

a dichroic beamsplitter positioned within infinity space of the stereo microscope and between the relay optics and the stereo microscope main objective;

wherein the shape control includes control for focal position of an imaged OCT beam that operates by motion of the at least one movable lens within the input beam zoom assembly;

wherein the stereo microscope main objective is configured to image a sample in a visible spectral range;

wherein the stereo microscope main objective is anti-reflection coated for a visible spectral range and an infrared spectral range; and

wherein the scan assembly is a telecentric scan assembly, the telecentric scan assembly comprising:

first and second scanning mirrors, the first scanning mirror relaying an image onto the second scanning mirror,

wherein an exit pupil of the sample arm is in a back focal plane of the stereo microscope main objective.

2. The OCT system of claim 1 , further comprising at least one additional optical signal path coupled into an OCT signal path through the dichroic beamsplitter.

3. The OCT system of claim 1 , further comprising a path length adjustment in the sample arm between the beam expander and the stereo microscope main objective to accommodate for variances in a focal length of the stereo microscope main objective.

4. The OCT system of claim 1 , wherein the exit pupil of sample arm optics comprise a virtual exit pupil.

5. The OCT system of claim 1 :

wherein the input beam zoom assembly comprises first and second positive lenses and a negative lens therebetween; and

wherein a numerical aperture of the system is set by controlling a first distance between the first positive lens and the negative lens and a second distance between the negative lens and the second positive lens.

6. The OCT system of claim 5 , wherein a focus of the OCT system is set by controlling a position of the second positive lens for a particular setting of numerical aperture.

7. The OCT system of claim 1 :

wherein at least a portion of an OCT path occupies a center channel of the stereo microscope;

wherein the OCT signal beam is directed towards a center field of the stereo microscope main objective; and

wherein any ocular paths of the stereo microscope are peripheral to the center field of the stereo microscope main objective.

8. The OCT system of claim 2 , wherein the beamsplitter occupies an area less than a clear aperture of the stereo microscope main objective.

9. The OCT system of claim 1 , wherein the sample is an eye.

10. The OCT system of claim 9 , wherein a retinal imaging lens assembly is situated between the stereo microscope main objective and the eye.

11. The OCT system of claim 10 , wherein the retinal imaging lens assembly images a conjugate of the at least one scanning mirror to a position posterior to a pupil plane of the eye.

12. The OCT system of claim 11 , wherein the retinal imaging lens assembly comprises at least one lens with at least one aspheric surface.

13. The OCT system of claim 1 , wherein the stereo microscope main objective comprises an achromatic doublet comprising a crown glass positive lens component and a flint glass negative lens component.

14. An optical coherence tomography (OCT) system for integration with a stereo microscope, the OCT system comprising:

a sample arm coupled to an imaging path of a stereo microscope, the sample arm comprising:

an input beam zoom assembly including at least one movable lens configured to provide shape control for an OCT signal beam;

a scan assembly following the input beam zoom assembly including at least one scanning mirror and configured for scanning of the OCT signal beam; and

relay optics following the scan assembly including a beam expander configured to set an OCT signal beam diameter incident on a main objective of the stereo microscope; and

a dichroic beamsplitter positioned within infinity space of the stereo microscope and between the relay optics and the stereo microscope main objective;

wherein the shape control includes control for focal position of an imaged OCT beam that operates by motion of the at least one movable lens within the input beam zoom assembly;

wherein the stereo microscope main objective is configured to image a sample in a visible spectral range;

wherein the stereo microscope main objective is anti-reflection coated for a visible spectral range and an infrared spectral range;

wherein the system comprises a telecentric scanning system; and

wherein the system comprises one of an entrance pupil and an exit pupil at infinity for an image space or object space telecentric system, respectively.

15. The OCT system of claim 14 , wherein the telecentric scanning system is configured to scan such that magnification is preserved for all points in object space and wherein a scanning beam is parallel to an optical access across a field of view.

Assignments (1)
CHANGE OF NAME Recorded May 2, 2024
From: BIOPTIGEN, INC.
To: LEICA MICROSYSTEMS NC, INC.
Reel/Frame 067682/0938 →
Continuity (5)
Continuation 14745980 · Jun 22, 2015
Continuation 14302793 · Jun 12, 2014
Division 13836576 · Mar 15, 2013
Provisional Application 61620645 · Apr 5, 2012
Related Publication 20160360961A1 · Dec 15, 2016