IP Library › Granted Patent US 9,925,182
Granted Patent B2
US 9,925,182 · App. 15/254,830 · Granted Mar 27, 2018

Compositions, dosage forms, and co-administration of an opioid agonist compound and an analgesic compound

Inventors: Timothy A. Riley (Worcester, MA); Juergen W. Pfeiffer (Moss Beach, CA); Hema Gursahani (Foster City, CA)
Assignee: Nektar Therapeutics
A61K31/485A61K31/196A61K31/4468A61K31/75A61K31/785A61K45/06A61K31/192A61K31/405A61K31/407A61K31/5415
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Quick Facts
Patent No.
US 9,925,182
App. No.
15/254,830
Granted
Mar 27, 2018
Kind
B2
Abstract

The present invention relates generally to the co-administration of an opioid agonist compound and an analgesic compound. In addition, the invention relates to, among other things, dosage forms for co-administration of an opioid agonist compound and an analgesic compound, methods for administering an opioid agonist compound and an analgesic compound, compositions comprising an opioid agonist compound and an analgesic compound, dosage forms comprising an opioid agonist compound and an analgesic compound, and so on.

Claims (27)

1. A composition comprising:

(i) a compound of the formula:

wherein n is an integer selected from 2 to 10, or a pharmaceutically accetable salt thereof; and

(ii) diclofenac.

2. The composition of claim 1 , wherein n is 2.

3. The composition of claim 1 , wherein n is 3.

4. The composition of claim 1 , wherein n is 4.

5. The composition of claim 1 , wherein n is 5.

6. The composition of claim 1 , wherein n is 6.

7. The composition of claim 1 , wherein n is 7.

8. The composition of claim 1 , wherein n is 8.

9. The composition of claim 1 , wherein n is 9.

10. The composition of claim 1 , wherein n is 10.

11. The composition of claim 1 in a unit dosage form.

12. The composition of claim 1 , wherein diclofenac is the only non-steroidal, anti-inflammatory drug (NSAID) present in the composition.

13. The composition of claim 1 , further comprising at least one pharmaceutically acceptable excipient.

14. A method of treating pain in a patient, comprising administering the composition of claim 1 to a patient in need thereof.

15. A method of treating pain in a patient, comprising administering:

(i) a compound of the formula:

wherein n is an integer selected from 2 to 10, or a pharmaceutically acceptable salt thereof; and

(ii) diclofenac;

to a patient in need thereof.

16. The method of claim 15 , wherein n is 4.

17. The method of claim 15 , wherein n is 5.

18. The method of claim 15 , wherein n is 6.

19. The method of claim 15 , wherein n is 7.

20. The method of claim 15 , wherein n is 9.

Assignments (8)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 9, 2023
From: INHERIS BIOPHARMA, INC.
To: NEKTAR THERAPEUTICS
Reel/Frame 062313/0501 →
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: INHERIS BIOPHARMA, INC.
Reel/Frame 052435/0062 →
CHANGE OF NAME Recorded Nov 15, 2019
From: INHERIS PHARMACEUTICALS, INC.
To: INHERIS BIOPHARMA, INC.
Reel/Frame 051038/0585 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 28, 2019
From: NEKTAR THERAPEUTICS
To: INHERIS PHARMACEUTICALS, INC.
Reel/Frame 050846/0461 →
SECURITY INTEREST Recorded Oct 28, 2019
From: INHERIS PHARMACEUTICALS, INC.
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 050846/0940 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 3, 2017
From: RILEY, TIMOTHY A.; PFEIFFER, JUERGEN W.; GURSAHANI, HEMA
To: NEKTAR THERAPEUTICS
Reel/Frame 041169/0874 →
SECURITY INTEREST Recorded Oct 4, 2016
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 039935/0246 →
Continuity (3)
Continuation 14356486
Provisional Application 61556693 · Nov 7, 2011
Related Publication 20170079975A1 · Mar 23, 2017