Skin Solution with Solubilized Bakuchiol
A composition for the treatment of acne includes hydrolyzed Psoralea corylifolia , containing a component bakuchiol, is solubilized in a water-based solution. The composition is for topical application to the skin. In various implementations, the composition is a water-based acne gel or a water-based cleanser. In a specific implementation, a composition includes Bakutrol™, which includes bakuchiol, and bisabolol. The composition can include a polysorbate surfactant. In implementations, these ingredients are combined with other active ingredients, including for example, salicylic acid, benzoyl peroxide, tretinoin, retinol, tazarotene, or an antibiotic, or a combination of these. A process of preparation of the composition allows for the stabilization of Bakutrol in solution.
1 . A method of preparing an aqueous mixture comprising:
mixing deionized water and hydroxyethylcellulose to obtain a first mixture;
applying heat to the first mixture until the first mixture reaches about 75 degrees Celsius;
adding disodium ethylenediaminetetraacetic acid (EDTA) and sodium pyrrolidone carboxylic acid (PCA) to the first mixture and mixing to obtain a second mixture;
allowing the second mixture to cool to from about 60 to 65 degrees Celsius;
mixing butylene glycol and salicylic acid to obtain a third mixture;
applying heat to the third mixture until the third mixture reaches about 65 degrees Celsius;
mixing the third mixture and second mixture together to obtain a fourth mixture;
allowing the fourth mixture to cool to from about 55 to 60 degrees Celsius;
adding glycolic acid and lactic acid to the fourth mixture and mixing to obtain a fifth mixture;
allowing the fifth mixture to cool to from about 50 to 55 degrees Celsius;
mixing deionized water and sodium hydroxide to obtain a sixth mixture;
mixing the sixth mixture and the fifth mixture together to obtain a seventh mixture;
allowing the seventh mixture to cool to from about 45 to 50 degrees Celsius;
mixing deionized water and perilla ocymoides leaf extract to obtain an eighth mixture;
mixing the eighth mixture and the seventh mixture to obtain a ninth mixture;
mixing deionized water and olea europaea fruit extract to obtain a tenth mixture;
mixing the tenth mixture and ninth mixture to obtain an eleventh mixture;
allowing the eleventh mixture to cool to from about 40 to 45 degrees Celsius;
adding sodium benzoate to the eleventh mixture and mixing to obtain a twelfth mixture;
solubilizing an unsolubilized hydrolyzed Psoralea corylifolia extract to obtain a solubilized hydrolyzed Psoralea corylifolia extract comprising mixing the unsolubilized hydrolyzed Psoralea corylifolia extract, bisabolol, and polysorbate 20 to obtain a thirteenth mixture, and adding the thirteenth mixture to the twelfth mixture at a temperature of less than about 40 degrees Celsius to obtain a fourteenth mixture, wherein the fourteenth mixture comprises the solubilized hydrolyzed Psoralea corylifolia extract;
mixing an encapsulated retinoid to the fourteenth mixture to obtain a fifteenth mixture;
allowing the fifteenth mixture to cool to about 35 degrees Celsius; and
obtaining an aqueous mixture that is a combination of the twelfth and thirteenth mixtures and the retinoid, wherein the aqueous mixture comprises a gel.
2 . The method of claim 1 wherein the retinoid comprises retinol.
3 . The method of claim 1 wherein the retinoid comprises tretinoin.
4 . The method of claim 1 wherein the retinoid comprises tazarotene.
5 . The method of claim 1 wherein the aqueous mixture comprises an antibiotic.
6 . The method of claim 5 wherein the antibiotic comprises clindamycin.
7 . The method of claim 5 wherein the antibiotic comprises erythromycin.
8 . The method of claim 1 comprising:
adding benzoyl peroxide to the polysorbate 20, bisabolol, and hydrolyzed Psoralea corylifolia extract of the thirteenth mixture.
9 . The method of claim 1 wherein the hydrolyzed Psoralea corylifolia extract comprises bakuchiol.
10 . The method of claim 1 wherein the aqueous mixture does not comprise an alcohol constituent.
11 . The method of claim 1 wherein the aqueous mixture does not comprise an oil constituent.
12 . The method of claim 1 wherein the solubilizing an unsolubilized hydrolyzed Psoralea corylifolia at a temperature of less than about 40 degrees Celsius results in a particle size of bakuchiol in the hydrolyzed Psoralea corylifolia extract that is of a sufficiently small size to penetrate skin pores into sebaceous follicles where the hydrolyzed Psoralea corylifolia extract can exert its antimicrobial and anti-inflammatory properties.
13 . A mixture comprising:
hydrolyzed Psoralea corylifolia extract;
bisabolol, wherein the hydrolyzed Psoralea corylifolia extract and bisabolol are solubilized together;
a retinoid; and
a surfactant, wherein the mixture is aqueous solution without oil and without an alcohol.
14 . The mixture of claim 13 further comprising at least one of benzoyl peroxide, tretinoin, tazarotene, or an antibiotic.
15 . The mixture of claim 14 wherein the antibiotic comprises at least one of clindamycin or erythromycin.
16 . The mixture of claim 13 wherein the retinoid comprises at least one of retinol, tretinoin, or tazarotene.
17 . The mixture of claim 13 wherein the retinoid is an encapsulated retinol.
18 . The mixture of claim 13 wherein the retinoid is an unencapsulated retinol, and the hydrolyzed Psoralea corylifolia extract, bisabolol, and unencapsulated retinol are solubilized together.
19 . The mixture of claim 13 wherein the surfactant comprises cocamidopropyl betaine having a weight-weight percentage greater than 10 percent.
20 . The mixture of claim 13 wherein the surfactant comprises decyl glucoside having a weight-weight percentage greater than 20 percent.