Pharmaceutical composition
The present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and ω-(methylsulfonyl)alkylamine or ω-(methylsulfonyl)alkylamide. The present invention is also directed to a method for treating inflammation, inflammatory-related disorders, or pain, by administering ω-(methylsulfonyl)alkylamine or ω-(methyl sulfonyl)alkylamide, or a pharmaceutically acceptable salt or solvate thereof to a subject in need thereof.
1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of 3-(methylsulfonyl)propionamide, or a pharmaceutically acceptable salt thereof.
2. The pharmaceutical composition according to claim 1 , wherein the compound has at least 90% (w/w) purity, and the composition is in a topical form of gels, creams, lotions, ointments, or patches.
3. The pharmaceutical composition according to claim 2 , wherein the pharmaceutically acceptable carrier is an emollient selected from the group consisting of: lauryl lactate, diethylene glycol monoethyl ether, caprylic/capric triglyceride, octisalate, silicone fluid, squalene, and sunflower oil.
4. The pharmaceutical composition according to claim 2 , wherein the pharmaceutically acceptable carrier is a permeation enhancer selected from the group consisting of lactate esters and diethylene glycol monoethyl ether.
5. The pharmaceutical composition according to claim 4 , further comprising acrylates/C10-30 alkyl and tris(2-hydroxyethyl)amine.
6. The pharmaceutical composition according to claim 1 , wherein the compound has at least 90% (w/w) purity, and the composition is in an oral form of tablets or capsules.
7. A method of treating an inflammatory skin disease or disorder, comprising the steps of:
identifying a subject suffering from an inflammatory skin disease or disorder, and
administering to the subject the pharmaceutical composition according to claim 1 , in an amount effective to treat the inflammatory skin disease or disorder, wherein the inflammatory skin disease or disorder is dermatitis, psoriasis, or acne.
8. The method according to claim 7 , wherein the method treats atopic dermatitis and alleviates one or more symptoms selected from the group consisting of erythema, induration, lichenification, scaling, and oozing and crusting.
9. The method according to claim 7 , wherein the method treats psoriasis and alleviates one or more symptoms selected from the group consisting of erythema, scaling, and/or thickness of the psoriasis lesions.
10. The method according to claim 7 , wherein the method treats acne and alleviates acne lesions selected from the groups consisting of closed comedones, papules, pustules, nodules, and cysts.