Low pH disinfectant composition
The invention provides for a low pH disinfectant composition that includes a relatively low amount of alcohol. Also provided is an article of manufacture that includes a textile and the composition, as well as methods of using the composition and article of manufacture (e.g., for reducing the number of microbes located upon a substrate, for killing or inhibiting a broad spectrum of microorganisms, for killing or inhibiting spore forming bacteria, and/or for disinfecting a substrate). The composition can optionally include a stable residual antimicrobial compound, thereby providing a combination of high-level disinfection and long-lasting residual effect.
1. A method of reducing the number of microbes located upon a substrate, the method comprising
contacting the substrate with an effective amount of a composition for a sufficient period of time effective to reduce the number of microbes located upon the substrate;
wherein the composition includes
isopropyl alcohol (2-propanol);
([(3-trimethoxysilyl)propyl]octadecyldimethylammonium chloride) (TPAC);
hydrogen peroxide (H 2 O 2 );
thymol (2-isopropyl-5-methylphenol);
a nonionic triblock copolymer surfactant composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide));
2-butoxyethanol;
a nonionic alkyl polyglucoside surfactant;
benzotriazole;
phosphoric acid; and
de-ionized water (q.s.).
2. The method of claim 1 , wherein
the isopropyl alcohol (2-propanol) is present in the composition in an amount that is between about 10 and 30 wt. %;
the ([(3-trimethoxysilyl)propyl]octadecyldimethylammonium chloride) (TPAC) is present in the composition in an amount that is between about 0.1 and 2 wt. %;
the hydrogen peroxide (H 2 O 2 ) is present in the composition in an amount that is between about 0.5 and 7.5 wt. %;
the thymol (2-isopropyl-5-methylphenol) is present in the composition in an amount that is between about 0.01 and 2 wt. %;
the nonionic triblock copolymer surfactant is present in the composition in an amount that is between about 0.1 and 1 wt. %;
the 2-butoxyethanol is present in the composition in an amount that is between about 0.5 and 10 wt. %;
the nonionic alkyl polyglucoside surfactant is present in the composition in an amount that is between about 0.1 and 5 wt. %;
the benzotriazole is present in the composition in an amount that is between about 0.1 and 1 wt. %; and
the phosphoric acid is present in the composition in an amount that is sufficient to bring the pH of the composition to less than about 3.5.
3. The method of claim 1 , wherein the composition is part of an article of manufacture that includes a textile; and wherein the composition is located on the surface of the textile, is at least partially embedded within the textile, or both; and wherein contacting the substrate with an effective amount of the composition includes contacting the substrate with the article of manufacture.
4. The method of claim 3 , wherein textile includes cloth, natural fiber, artificial fiber, animal textile, wool, silk, plant textile, cotton, flax, jute, mineral textile, asbestos, glass fibers, synthetic textile, nylon, polyester, acrylic, acramid, spandex, olefin fiber, ingeo, lurex, or combinations thereof.
5. The method of claim 1 , wherein up to about 6 logs of the microbes are inactivated within about 2 minutes or less of contacting the substrate with the composition.
6. The method of claim 1 , wherein up to about 6 logs of at least one of P. aeruginosa, S. aureus, E. hirae, M. terrae, M. intracellulare, M. tuberculosis and M. avium, M. bovis, Salmonella choleraesuis , Methicillin-resistant S. aureus (MRSA), vancomycin-resistant enterococcus (VRE), staph-reduced vancormycin, trichophyton mentagrophytes, hepatitis B, hepatitis C, HIV-1, herpes type 1, herpes type 2, influenza A2, parvovirus, and norovirus are inactivated within about 2 minutes or less of contacting the substrate with the composition.
7. The method of claim 1 , wherein up to about 6 logs of Mycobacterium terrae or Mycobacterium tuberculosis is inactivated within about 2 minutes or less of contacting the substrate with the composition.
8. The method of claim 1 , wherein, after contacting the substrate with the composition, a residual coating of the composition is present on the surface of the substrate and wherein the residual coating has antimicrobial activity; and wherein the residual coating is present on the surface of the substrate for at least about 24 hours.
9. A method of killing or inhibiting a microorganism, the method comprising
contacting the microorganism with an antimicrobially effective amount of a composition for a period of time sufficient to kill or inhibit the microorganism;
wherein the composition includes
isopropyl alcohol (2-propanol);
([(3-trimethoxysilyl)propyl]octadecyldimethylammonium chloride) (TPAC);
hydrogen peroxide (H 2 O 2 );
thymol (2-isopropyl-5-methylphenol);
a nonionic triblock copolymer surfactant composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide));
2-butoxyethanol;
a nonionic alkyl polyglucoside surfactant;
benzotriazole;
phosphoric acid; and
de-ionized water (q.s.).
10. The method of claim 9 , wherein
the isopropyl alcohol (2-propanol) is present in the composition in an amount that is between about 10 and 30 wt. %;
the ([(3-trimethoxysilyl)propyl]octadecyldimethylammnonium chloride) (TPAC) is present in the composition in an amount that is between about 0.1 and 2 wt. %;
the hydrogen peroxide (H 2 O 2 ) is present in the composition in an amount that is between about 0.5 and 7.5 wt. %;
the thymol (2-isopropyl-5-methylphenol) is present in the composition in an amount that is between about 0.01 and 2 wt. %;
the nonionic triblock copolymer surfactant is present in the composition in an amount that is between about 0.1 and 1 wt. %;
the 2-butoxyethanol is present in the composition in an amount that is between about 0.5 and 10 wt. %;
the nonionic alkyl polyglucoside surfactant is present in the composition in an amount that is between about 0.1 and 5 wt. %;
the benzotriazole is present in the composition in an amount that is between about 0.1 and 1 wt. %; and
the phosphoric acid is present in the composition in an amount that is sufficient to bring the pH of the composition to less than about 3.5.
11. The method of claim 9 , wherein the composition is part of an article of manufacture that includes a textile; and wherein the composition is located on the surface of the textile, is at least partially embedded within the textile, or both; and wherein contacting the substrate with an effective amount of the composition includes contacting the substrate with the article of manufacture.
12. The method of claim 11 , wherein textile includes cloth, natural fiber, artificial fiber, animal textile, wool, silk, plant textile, cotton, flax, jute, mineral textile, asbestos, glass fibers, synthetic textile, nylon, polyester, acrylic, acramid, spandex, olefin fiber, ingeo, lurex, or combinations thereof.
13. The method of claim 9 , wherein up to about 6 logs of the microorganism are inactivated within about 2 minutes or less of contacting the composition.
14. The method of claim 9 , wherein up to about 6 logs of at least one of P. aeruginosa, S. aureus, E. hirae, M. terrae, M. intracellulare, M. tuberculosis and M. aviurm, M. bovis, Salmonella choleraesuis , Methicillin-resistant S. aureus (MRSA), vanconycin-resistant enterococcus (VRE), staph-reduced vancomycin, trichophyton mentagrophytes, hepatitis B, hepatitis C, HIV-1, herpes type 1, herpes type 2, influenza A2, parvovirus, and norovirus are inactivated within about 2 minutes or less of contacting the composition.
15. The method of claim 9 , wherein up to about 6 logs of Mycobacterium terrae or Mycobacterium tuberculosis is inactivated within about 2 minutes or less of contacting the composition.
16. A method of disinfecting a substrate, the method comprising
contacting the substrate with an effective amount of a composition for a sufficient period of time effective to disinfect the substrate;
wherein the composition includes
isopropyl alcohol (2-propanol);
([(3-trimethoxysilyl)propyl]octadecyldimethylammonium chloride) (TPAC);
hydrogen peroxide (H 2 O 2 );
thymol (2-isopropyl-5-methylphenol);
a nonionic triblock copolymer surfactant composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide));
2-butoxyethanol
a nonionic alkyl polyglucoside surfactant;
benzotriazole;
phosphoric acid; and
de-ionized water (q.s.).
17. The method of claim 16 , wherein
the isopropyl alcohol (2-propanol) is present in the composition in an amount that is between about 10 and 30 wt. %;
the ([(3-trimethoxysilyl)propyl]octadecyldimethylammonium chloride) (TPAC) is present in the composition in an amount that is between about 0.1 and 2 wt. %;
the hydrogen peroxide (H 2 O 2 ) is present in the composition in an amount that is between about 0.5 and 7.5 wt. %;
the thymol (2-isopropyl-5-methylphenol) is present in the composition in an amount that is between about 0.01 and 2 wt. %;
the nonionic tribiock copolymer surfactant is present in the composition in an amount that is between about 0.1 and 1 wt. %;
the 2-butoxyethanol is present in the composition in an amount that is between about 0.5 and 10 wt. %;
the nonionic alkyl polyglucoside surfactant is present in the composition in an amount that is between about 0.1 and 5 wt. %;
the benzotriazole is present in the composition in an amount that is between about 0.1 and 1 wt. %; and
the phosphoric acid is present in the composition in an amount that is sufficient to bring the pH of the composition to less than about 3.5.
18. The method of claim 16 , wherein the composition is part of an article of manufacture that includes a textile; and wherein the composition is located on the surface of the textile, is at least partially embedded within the textile, or both; and wherein contacting the substrate with an effective amount of the composition includes contacting the substrate with the article of manufacture.
19. The method of claim 18 , wherein textile includes cloth, natural fiber, artificial fiber, animal textile, wool, silk, plant textile, cotton, flax, jute, mineral textile, asbestos, glass fibers, synthetic textile, nylon, polyester, acrylic, acramid, spandex, olefin fiber, ingeo, lurex, or combinations thereof.
20. The method of claim 16 , wherein, after contacting the substrate with the composition, a residual coating of the composition is present on the surface of the substrate and wherein the residual coating has antimicrobial activity; and wherein the residual coating is present on the surface of the substrate for at least about 24 hours.