TCO conjugates and methods for delivery of therapeutic agents
The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
1. A bioactive composition comprising:
a therapeutic agent other than doxorubicin, vancomycin, and paclitaxel;
a binding agent comprising a trans-cyclooctene; and
a linker comprising from about 1 to about 10 linking atoms, covalently linking the binding agent to the therapeutic agent.
2. The composition of claim 1 , wherein the linker comprises the structure of:
3. The composition of claim 1 , wherein the binding agent and the linker together have the structure selected from the group consisting of
4. The bioactive composition of claim 1 , wherein the therapeutic agent is daptomycin, irinotecan, SN-38, amoxicillin, cyclic AMP, doxycyclin, amphotericin, ixabepilone, podophyllotoxin, patupilone, or rapamycin.
5. The bioactive composition of claim 4 , wherein the therapeutic agent is daptomycin.
6. The bioactive composition of claim 4 , wherein the therapeutic agent is irinotecan.
7. The bioactive composition of claim 4 , wherein the therapeutic agent is SN-38.
8. The bioactive composition of claim 4 , wherein the therapeutic agent is amoxicillin.
9. The bioactive composition of claim 4 , wherein the therapeutic agent is cyclic AMP.
10. The bioactive composition of claim 4 , wherein the therapeutic agent is doxycyclin.
11. The bioactive composition of claim 4 , wherein the therapeutic agent is amphotericin.
12. A bioactive composition comprising a therapeutic agent other than doxorubicin, wherein the therapeutic agent is linked by a covalent bond to a structure
13. The bioactive composition of claim 12 , wherein the therapeutic agent is vancomycin, paclitaxel, daptomycin, etoposide, irinotecan, SN-38, amoxicillin, cyclic AMP, doxycyclin, amphotericin, ixabepilone, podophyllotoxin, patupilone, or rapamycin.
14. The bioactive composition of claim 13 , wherein the therapeutic agent is vancomycin.
15. The bioactive composition of claim 13 , wherein the therapeutic agent is paclitaxel.
16. The bioactive composition of claim 13 , wherein the therapeutic agent is daptomycin.
17. The bioactive composition of claim 13 , wherein the therapeutic agent is SN-38.
18. A bioactive composition comprising:
a diagnostic agent;
a binding agent comprising a trans-cyclooctene; and
a linker comprising from about 1 to about 10 linking atoms, covalently linking the binding agent to the diagnostic agent.
19. The bioactive composition of claim 18 , wherein the diagnostic agent is an optical probe.