Lubricant formulations
A composition for lubricant formulations is disclosed. The composition may include hypochlorite, dimethicone, and an emulsifier for improvement of lubricity. Methods of making and using the lubricant formulations are also disclosed.
1. A method for inhibiting a microbial infection, the method comprising:
providing a lubricant comprising:
hypochlorite;
an emulsifier comprising sodium magnesium silicate; and
a silicone polymer; and
applying the lubricant to a microbial infection.
2. The method of claim 1 , wherein the infection is a viral infection.
3. The method of claim 2 , wherein the viral infection comprises an HIV, HSV, or HBV infection.
4. The method of claim 1 , wherein the infection is a bacterial infection.
5. The method of claim 4 , wherein the bacterial infection comprises a chlamydia, gonorrhoeae, Gardnerella, Mycoplasma , or Campylobacter infection.
6. The method of claim 1 , wherein the infection is a fungal infection.
7. The method of claim 6 , wherein the fungal infection is caused by one or more species of yeast of the Candida genus.
8. The method of claim 7 , wherein the species of yeast of the Candida genus is selected from the group consisting of Candida albicans, Candida dubliniensis, Candida parapsilosis, Candida tropicalis, Candida kerfyr, Candida guilliermondii, Candida inconspicua, Candida famata, Candida glabrata, Candida krusei, Candida lusitaniae , and combinations thereof.
9. The method of claim 1 , wherein the hypochlorite is in an amount of about 50 to about 100 ppm.
10. The method of claim 1 , wherein the sodium magnesium silicate is in an amount of about 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.25%, 3.5%, 4%, 4.5%, 5%, 6%, 7%, 10%, or 15% w/v.
11. The method of claim 1 , wherein the silicone polymer is in an amount of about 0.5%, 1%, 5%, 10%, 15%, 20%, 30%, 40%, or 50% w/v.
12. The method of claim 1 , wherein the hypochlorite is in an amount of about 75 ppm, wherein the sodium magnesium silicate is in an amount of about 3.25% w/v, and wherein the silicone polymer comprises dimethicone in an amount of about 10% w/v.
13. A method for treating an irritation or discomfort in a genital area, the method comprising:
providing a lubricant comprising:
hypochlorite;
an emulsifier comprising sodium magnesium silicate; and
a silicone polymer; and
applying the lubricant to an irritation or discomfort in a genital area.
14. The method of claim 13 , wherein the genital area is the vaginal or vulvovaginal area.
15. The method of claim 13 , wherein applying the lubricant comprises applying the lubricant to a genital area or applying the lubricant to a medical instrument for insertion, penetration or introduction into a subject.
16. The method of claim 15 , wherein the medical instrument is a speculum, catheter, or ultrasound.
17. The method of claim 13 , wherein the hypochlorite is in an amount of about 50 to about 100 ppm.
18. The method of claim 13 , wherein the sodium magnesium silicate is in an amount of about 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.25%, 3.5%, 4%, 4.5%, 5%, 6%, 7%, 10%, or 15% w/v.
19. The method of claim 13 , wherein the silicone polymer is in an amount of about 0.5%, 1%, 5%, 10%, 15%, 20%, 30%, 40%, or 50% w/v.
20. The method of claim 13 , wherein the hypochlorite is in an amount of about 75 ppm, wherein the sodium magnesium silicate is in an amount of about 3.25% w/v, and wherein the silicone polymer comprises dimethicone in an amount of about 10% w/v.