Sulfonamide compounds for inhibition of metastatic tumor growth
Therapeutic ureido-sulfonamide compositions having compounds with the formula R-Q-Ar—SO 2 NH 2 are disclosed, which compounds selectively inhibit CAIX and CAXII, and which are effective to inhibit hypoxic tumor growth, suppress metastases, and impair and deplete cancer stem cells in mammals.
1. A pharmaceutical composition comprising:
a compound selected from the group consisting of 4-{[(4′-Fluorophenyl)carbamoyl]amino}benzenesulfonamide (MST-104) and 4-{[(3′-Nitrophenyl)carbamoyl]amino}benzenesulfonamide (MST-119); and
a pharmaceutically acceptable excipient comprising salts, lipids, simple sugars, or a mixture of polyethylene glycol, ethanol and saline;
wherein the pharmaceutical composition is suitable for injection, topical application or ingestion.
2. A pharmaceutical composition according to claim 1 wherein the compound is 4-{[(4′-Fluorophenyl)carbamoyl]amino}benzenesulfonamide (MST-104).
3. A pharmaceutical composition according to claim 1 wherein the compound is 4-{[(3′-Nitrophenyl)carbamoyl]amino}benzenesulfonamide (MST-119).