Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors
The present invention provides oxazine compounds, method of using and method of making oxazine compounds and its pharmaceutical use.
1. A compound selected from 3-(3,5-dibromo-4-hydroxybenzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 3-(3,5-dibromobenzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 3-(3,5-dibromo-4-hydroxybenzylidene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; 3-(3,4,5-trimethoxybenzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 4-chloro-3-(3,5-dibromobenzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; (Z)-3-(1H-pyrrol-2-yl)methylene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; (Z)-3-(1H-pyrrol-2-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; 4-chloro-3-(3,4,5-trimethoxybenzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 3-(3,4,5-trimethoxybenzylidene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; 3-(4-(dimethylamino)benzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 4-chloro-3-(4-(dimethylamino)benzylidene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; 3-(4-(dimethylamino)benzylidene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; (Z)-3-(1H-indol-3-yl)methylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; (Z)-3-(1H-indol-3-yl)methylene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; (Z)-3-(1H-indol-3-yl)methylene)-4-chloro-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; (Z)-3-(thiophen-2-ylmethylene)-1H-pyrrolo[3,2-b]pyridin-2(3H)-one; (Z)-3-(thiophen-2-ylmethylene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; (Z)-4-chloro-3-(thiophen-2-ylmethylene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one; and (E)-3-(furan-2-ylmethylene)-1H-pyrrolo[2,3-b]pyridin-2(3H)-one.