Compositions and methods for inhibiting the growth of neisseria gonorrhoeae
View Patent ↗Compositions and methods for preventing and treating Neisseria gonorrhoeae infection with AR-12 alone or in combination with antibiotics are provided.
1. A method of reducing the amount of viable Neisseria gonorrhoeae in a human having a cervical epithelial cell infection with Neisseria gonorrhoeae comprising administering 2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-2-yl)phenyl)acetamide (AR-12) to a human infected with Neisseria gonorrhoeae.
2. The method of claim 1 , wherein the amount of AR-12 administered to the infected human is sufficient to achieve a blood or tissue concentration of at least about 1 to 12 μM.
3. The method of claim 2 , wherein the amount of AR-12 administered to the infected human is sufficient to achieve a blood or tissue concentration of at least about 10 μM.
4. The method of claim 1 , wherein AR-12 is administered to infected cervical tissue.
5. The method of claim 4 , wherein AR-12 contacts the infected cervical tissue for at least about 3 hours.
6. The method of claim 5 , wherein AR-12 contacts the infected cervical tissue from about 3 to about 24 hours.
7. The method of claim 1 , further comprising administering an antibiotic to the infected human.
8. The method of claim 7 , wherein the antibiotic is selected from the group consisting of ceftriaxone and gentamicin.
9. The method of claim 8 , wherein the antibiotic is provided in an amount from about 5 μg/ml to about 100 μg/ml.
10. The method of claim 2 , wherein the amount of AR-12 administered to the infected human is from about 10 to 1600 mg once or twice daily.
11. The method of claim 1 , wherein AR-12 is administered in an amount from about 1 to about 1000 mg.
12. The method of claim 11 , wherein the amount of AR-12 is from about 1 to about 500 mg.
13. The method of claim 11 , wherein the amount of AR-12 is from about 10 to about 200 mg.