Wound care compositions
Glass-based particles of a biocompatible material which comprises 40 to about 80 wt % borate (B 2 O 3 ) intermixed into a carrier which is an ointment, cream, or surgical glue.
1. Glass-based particles of a biocompatible material intermixed into a carrier, wherein the glass-based particles comprise, in wt %:
B 2 O 3
50 to 80
P 2 O 5
0 to 10
SiO 2
0 to 18
Al 2 O 3
0 to 3
F
0 to 4
two or more alkali oxides selected from the group consisting of Li 2 O, Na 2 O, K 2 O, and Rb 2 O in a cumulative concentration between 5 and 25 wt %;
two or more alkaline earth oxides selected from the group consisting of MgO, SrO, BaO, and CaO in a cumulative concentration between 1 and 30 wt %;
wherein the glass-based particles comprise from 50 to 80 wt % B 2 O 3 , 1 to 25 wt % Na 2 O, 1 to 25% K 2 O, 1 to 40 wt % CaO, 1 to 25 wt % MgO, and 1 to 10 wt % P 2 O 5 ;
and optionally one or more trace elements selected from the group consisting of Ag, Cu, F, Fe, Mn, Mo, Ni, Sr, and Zn in a concentration between about 0.05 and 10 wt % per trace element chemically dissolved in the biocompatible material;
wherein the carrier is a biocompatible ointment or cream or a surgical glue.
2. The glass-based particles intermixed into a carrier of claim 1 , wherein the glass-based particles comprise said one or more trace elements selected from the group consisting of Ag, Cu, F, Fe, Mn, Mo, Ni, Sr, and Zn in a concentration between about 0.05 and 10 wt % per trace element chemically dissolved in the biocompatible material.
3. The glass-based particles intermixed into a carrier of claim 1 , wherein the carrier is a surgical glue.
4. The glass-based particles intermixed into a carrier of claim 1 wherein Ca concentration in the glass-based particles is controlled to less than 5 wt %.
5. The glass-based particles intermixed into a carrier of claim 1 wherein the glass-based particles comprise said one or more trace elements selected from the group consisting of Ag, Cu, F, Fe, Mn, Mo, Ni, Sr, and Zn in a concentration between about 0.1 and 2.5 wt % per trace element chemically dissolved in glass.
6. The glass-based particles intermixed into a carrier of claim 1 wherein the glass-based particles comprise Cu in a concentration between about 0.05 and 10 wt % chemically dissolved in the glass.
7. The glass-based particles intermixed into a carrier of claim 4 wherein the one or more trace elements comprise Cu in a concentration is between 0.1 and 2.5 wt %.
8. The glass-based particles intermixed into a carrier of claim 4 wherein the one or more trace elements comprise 0.05 to 5 wt % Zn.
9. The glass-based particles intermixed into a carrier of claim 1 wherein the glass-based particles affirmatively comprise the Cu as the trace element in the concentration between about 0.05 and 10 wt %.
10. The glass-based particles intermixed into a carrier of claim 1 wherein the particles comprise microspheres.
11. The glass-based particles intermixed into a carrier of claim 1 wherein the particles are biodegradable.
12. The glass-based particles intermixed into a carrier of claim 1 wherein the glass-based particles have a particle size of between 1 and 300 μm.
13. The glass-based particles intermixed into a carrier of claim 1 wherein the glass-based particles have a particle size of between 3 and 50 μm.
14. The glass-based particles intermixed into a carrier of claim 1 wherein at least 10 wt % of the particles have a first composition and at least 10 wt % of the particles have a second composition different from the first composition.
15. Glass-based particles of a biocompatible material intermixed into a carrier, wherein the glass-based particles consist of, in wt %:
B 2 O 3
50 to 80
P 2 O 5
0 to 10
SiO 2
0 to 18
Al 2 O 3
0 to 3
F
0 to 4
two or more alkali oxides selected from the group consisting of Li 2 O, Na 2 O, K 2 O, and Rb 2 O in a cumulative concentration between 5 and 25 wt %;
two or more alkaline earth oxides selected from the group consisting of MgO, SrO, BaO, and CaO in a cumulative concentration between 1 and 30 wt %;
wherein the glass-based particles comprise from 50 to 80 wt % B 2 O 3 , 1 to 25 wt % Na 2 O, 1 to 25% K 2 O, 1 to 40 wt % CaO, 1 to 25 wt % MgO, and 1 to 10 wt % P 2 O 5 ;
and optionally one or more trace elements selected from the group consisting of Ag, Cu, F, Fe, Mn, Mo, Ni, Sr, and Zn in a concentration between about 0.05 and 10 wt % per trace element chemically dissolved in the biocompatible material.
16. The glass-based particles of a biocompatible material intermixed into a carrier of claim 1 , wherein the carrier is an ointment.