Disubstituted triazole analogs
The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are provided.
1. A compound, the compound of Formula (I):
wherein:
R 1 , R 5 and R 6 are hydrogen and R 2 , R 3 , and R 4 are independently chosen from hydrogen, methoxy, and hydroxyl, with the proviso that at least two of R 2 , R 3 , and R 4 are methoxy; and
Ar is an aryl or substituted aryl group.
2. The compound of claim 1 , wherein Ar is chosen from phenyl, benzyl, substituted benzyl, benzoyl, substituted benzoyl, naphthyl, substituted naphthyl, naphthoyl, substituted naphthoyl, benzenesulphonyl, substituted benzenesulphonyl, heteroaryl; substituted heteroaryl, aroyl, heteroaroyl.
3. The compound of claim 1 , wherein the compound is Formula (I)(a):
4. The compound of claim 1 , wherein the compound is Formula (I)(b):
5. The compound of claim 1 , wherein the compound is Formula (I)(c):
6. The compound of claim 1 , wherein the compound is Formula (I)(d):
7. The compound of claim 1 , wherein the compound is Formula (I)(e):
8. The compound of claim 1 , wherein the compound is Formula (I)(f):
9. A pharmaceutical composition comprising a compound of Formula (I):
wherein:
R 1 , R 5 , and R 6 are hydrogen and R 2 , R 3 , and R 4 are independently chosen from hydrogen, methoxy, and hydroxyl, with the proviso that at least two of R 2 , R 3 , and R 4 are methoxy; and
Ar is an aryl or substituted aryl group.
10. The pharmaceutical composition of claim 9 , wherein the compound of Formula (I) is selected from the group comprising Formula (I)(a), (I)(b), (I)(c), (I)(d), (I)(e), and (I)(f).
11. A compound, the compound selected from the group consisting of: