IP Library Granted Patent US 10,059,955
Granted Patent B2
US 10,059,955 · App. 15/285,182 · Granted Aug 28, 2018

Patent

Inventors: Curtis Wilkerson (Swartz Creek, MI); John Ralph (Madison, WI); Saunia Withers (Durham, NC); Shawn D. Mansfield (Vancouver, CA)
Assignees: Board of Trustees of Michigan State University; The University of British Columbia; Wisconsin Alumni Resarch Foundation
C12N15/8255C12N9/1029C12N15/8223C12N15/8243C12Y203/01C12Y203/01133
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Quick Facts
Patent No.
US 10,059,955
App. No.
15/285,182
Granted
Aug 28, 2018
Kind
B2
Abstract

The invention relates to isolated nucleic acids encoding a feruloyl-CoA:monolignol transferase and feruloyl-CoA:monolignol transferase enzymes. The isolated nucleic acids and/or the enzymes enable incorporation of monolignol ferulates into the lignin of plants, where such monolignol ferulates include, for example, p-coumaryl ferulate, coniferyl ferulate, and/or sinapyl ferulate. The invention also includes methods and plants that include nucleic acids encoding a feruloyl-CoA:monolignol transferase enzyme and/or feruloyl-CoA:monolignol transferase enzymes.

Claims (20)

1. A plant comprising a heterologous feruloyl-CoA:monolignol transferase nucleic acid segment encoding a feruloyl-CoA:monolignol transferase polypeptide with at least 95% sequence identity to SEQ ID NO:9 or SEQ ID NO:16, and a promoter operably linked to the nucleic acid segment, wherein the promoter is functional in a cell of the plant.

2. The plant of claim 1 , wherein the promoter is a promoter functional or active during plant development or growth.

3. The plant of claim 1 , wherein the promoter is a promoter functional or active in woody tissues of a plant.

4. The plant of claim 1 , wherein the promoter is heterologous to the feruloyl-CoA:monolignol transferase nucleic acid segment.

5. The plant of claim 1 , wherein the genome of the plant is stably transformed with the heterologous feruloyl-CoA:monolignol transferase nucleic acid.

6. The plant of claim 1 , wherein the plant has an increased percent of monolignol ferulates in the plant's lignin.

7. The plant of claim 1 , wherein the feruloyl-CoA:monolignol transferase nucleic acid is transmitted through a complete normal sexual cycle of the plant to the next generation.

8. The plant of claim 1 , where the polypeptide has one or more conservative amino acid substitutions.

9. A plant cell or plant seed comprising a heterologous feruloyl-CoA:monolignol transferase nucleic acid segment encoding a feruloyl-CoA:monolignol transferase polypeptide with at least 95% sequence identity to SEQ ID NO:9 or SEQ ID NO:16, and a promoter operably linked to the nucleic acid segment, wherein the promoter is functional in a cell of a plant generated from the plant cell or plant seed.

10. The plant cell or plant seed of claim 9 , where the polypeptide has one or more conservative amino acid substitutions.

11. The plant cell or plant seed of claim 9 , wherein the promoter is a promoter functional or active during plant development or growth.

12. The plant cell or plant seed of claim 9 , wherein the promoter is a promoter functional or active in woody tissues of a plant.

13. The plant cell or plant seed of claim 9 , wherein the promoter is heterologous to the feruloyl-CoA:monolignol transferase nucleic acid segment.

14. A method for increasing the content of monolignol ferulates in lignin within a plant, comprising:

(a) planting the plant seed of claim 9 ; and

(b) cultivating a plant germinated from the plant seed, to thereby increase the content of monolignol ferulates in the lignin within the plant.

15. The method of claim 14 , wherein the plant's genome is stably transformed with the heterologous feruloyl-CoA:monolignol transferase nucleic acid.

16. The method of claim 14 , wherein the feruloyl-CoA:monolignol transferase nucleic acid is transmitted through a complete normal sexual cycle of the plant to a next generation seed.

17. The method of claim 14 , wherein the plant has an increased percent of monolignol ferulates in the plant's lignin.

18. The method of claim 14 , where the polypeptide has one or more conservative amino acid substitutions.

Assignments (4)
CONFIRMATORY LICENSE Recorded Nov 22, 2019
From: MICHIGAN STATE UNIVERSITY
To: UNITED STATES DEPARTMENT OF ENERGY
Reel/Frame 051097/0495 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 31, 2016
From: WILKERSON, CURTIS; WITHERS, SAUNIA
To: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
Reel/Frame 040174/0914 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 31, 2016
From: MANSFIELD, SHAWN D.
To: THE UNIVERSITY OF BRITISH COLUMBIA
Reel/Frame 040175/0001 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 31, 2016
From: RALPH, JOHN
To: WISCONSIN ALUMNI RESEARCH FOUNDATION
Reel/Frame 040176/0958 →
Continuity (3)
Continuation 14349137
Provisional Application 61544063 · Oct 6, 2011
Related Publication 20170096675A1 · Apr 6, 2017