TREATMENT OF SHORT BOWEL SYNDROME PATIENTS WITH COLON-IN-CONTINUITY
Intestinal absorption is enhanced in short bowel syndrome patients presenting with colon-in-continuity by treatment with a GLP-2 receptor agonist, such as teduglutide.
1 . A method of up-regulating protein transport of a patient having short bowel syndrome, who receives an amount of parenteral nutrition each week, and who presents with colon-in-continuity with remnant small intestine, said method comprising administering h(Gly2)GLP-2 to said patient using a dosing regimen effective to upregulate the protein transport of said patient log.
2 . A method as defined in claim 1 , wherein the h(Gly2)GLP-2 is administered at a daily dose of from 5 to 500 μg/kg.
3 . A method as defined in claim 2 , wherein the h(Gly2)GLP-2 is administered at a daily dose of from 30 to 150 μg/kg.
4 . A method as defined in claim 1 , wherein the h(Gly2)GLP-2 is administered by subcutaneous injection.
5 . A method as defined in claim 4 , wherein the subcutaneous injection is into the abdomen, thigh, or arm.
6 . A method as defined in claim 1 , wherein the patient is an adult.
7 . A method as defined in claim 1 , wherein said regimen comprises administration of said h(Gly2)GLP-2 over a period of at least 21 days.
8 . A method as defined in claim 1 , wherein said patient is an adult and the h(Gly2)GLP-2 is administered at a daily dose of from 30 to 150 μg/kg by subcutaneous injection.