Methods of treating pancreatic cancer
Provided herein are methods for the treatment of metastatic pancreatic cancer comprising administration of a composition comprising nanoparticles comprising a taxane (such as paclitaxel) and a carrier protein in combination with gemcitabine.
1. A method of treating metastatic or locally advanced pancreatic cancer in a human individual comprising administering to the individual (a) an effective amount of a composition comprising nanoparticles comprising paclitaxel and an albumin; and (b) an effective amount of gemcitabine, wherein the individual is selected for treatment based on (i) having previously received a Whipple procedure or (ii) having a biliary stent.
2. The method of claim 1 , wherein the pancreatic cancer is pancreatic adenocarcinoma.
3. The method of claim 1 , wherein the individual has Karnofsky performance status (KPS) of between 70 and 80.
4. The method of claim 1 , wherein the individual has a high level of hENT1 (human equilibrative nucleoside transporter 1).
5. The method of claim 1 wherein the composition comprising nanoparticles comprising paclitaxel and albumin is administered intravenously.
6. The method of claim 1 , wherein the dose of paclitaxel in the nanoparticle composition is about 50 mg/m 2 to about 200 mg/m 2 .
7. The method of claim 6 , wherein the dose of paclitaxel in the nanoparticle composition is about 125 mg/m 2 .
8. The method of claim 6 , wherein the composition comprising nanoparticles comprising paclitaxel and albumin is administered weekly, three out of four weeks.
9. The method of claim 1 , wherein the albumin is human serum albumin.
10. The method of claim 1 , wherein the nanoparticles in the composition have an average diameter of no greater than about 200 nm.
11. The method of claim 1 , wherein the weight ratio of albumin and paclitaxel in the nanoparticle composition is about 9:1 or less.
12. The method of claim 1 , wherein the paclitaxel in the nanoparticles is coated with the albumin.
13. The method of claim 1 , wherein gemcitabine is administered to the individual at about 500 mg/m 2 to about 2000 mg/m 2 .
14. The method of claim 13 , wherein gemcitabine is administered to the individual at about 1000 mg/m 2 .
15. The method of claim 13 , wherein gemcitabine is administered weekly, three out of four weeks.
16. The method of claim 13 , wherein gemcitabine is administered intravenously.
17. The method of claim 1 , wherein the method is for first-line treatment.
18. The method of claim 1 , further comprising selecting the individual for treatment based on the individual (i) having previously received a Whipple procedure or (ii) having a biliary stent.
19. The method of claim 10 , wherein the paclitaxel in the nanoparticles is coated with the albumin, and wherein the weight ratio of albumin and paclitaxel in the nanoparticle composition is about 9:1 or less.
20. The method of claim 1 , wherein the individual is selected for treatment based on having previously received a Whipple procedure.
21. The method of claim 20 , wherein the nanoparticles in the composition have an average diameter of no greater than about 200 nm, wherein the paclitaxel in the nanoparticles is coated with the albumin, and wherein the weight ratio of albumin and paclitaxel in the nanoparticle composition is about 9:1 or less.
22. The method of claim 1 , wherein the individual is selected for treatment based on having a biliary stent.
23. The method of claim 22 , wherein the nanoparticles in the composition have an average diameter of no greater than about 200 nm, wherein the paclitaxel in the nanoparticles is coated with the albumin, and wherein the weight ratio of albumin and paclitaxel in the nanoparticle composition is about 9:1 or less.