Kinase inhibitor
There is provided a compound of formula VIIa, wherein Q x represents —C(O)O—C 1-4 alkyl, or a salt or protected derivative thereof, and other compounds that are useful in the preparation of compounds that have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and has use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
1. A compound of formula VIIa,
wherein Q x represents —C(O)O—C 1-4 alkyl,
or a salt thereof.
2. A compound of formula VIIa, or a salt thereof, as claimed in claim 1 , wherein said compound is methyl 4-((4-((4-(3-(5-(tert-butyl)-2-methoxy-3-(methylsulfonamido)phenyl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)amino)-2-methoxybenzoate.
3. A process for the preparation of a compound of formula VIIa, as defined in claim 1 , which process comprises:
(a) reaction of a compound of formula IIp,
with a compound of formula IIIp,
wherein one of Z 1p and Z 2p is a structural fragment of formula IV,
and the other of Z 1p and Z 2p is a structural fragment of formula Vp
wherein Q x represents —C(O)O—C 1-4 alkyl;
(b) reaction of a compound of formula IIap
wherein Z 1p is as defined above, with a suitable azide-forming agent,
which reaction is followed, without isolation, by thermal rearrangement of the intermediate acyl azide (of formula Z 1p —C(O)—N 3 ) to provide, in situ, a compound of formula II, which compound is then reacted with a compound of formula IIIp as defined above;
(c) reaction of a compound of formula IIbp,
wherein LG 1 represents a leaving group and Z 1p is as defined above, with a compound of formula IIIp, as defined above; or
(d) reaction of a compound of formula VI,
wherein LG 2 represents a leaving group, with a compound of formula VIIp,
wherein Q x is as defined above.