System and method for identifying autoregulation zones

1. A system configured to monitor autoregulation, the system comprising:

a medical sensor configured to generate a regional oxygen saturation signal indicative of a blood oxygen saturation of a patient;

a controller comprising a processor configured to:

receive the regional oxygen saturation signal and a blood pressure signal indicative of a blood pressure of the patient;

determine a cerebral oximetry index (COx) based on the blood pressure signal and the regional oxygen saturation signal;

determine, using a data clustering algorithm, a plurality of clusters, each cluster of the plurality of clusters comprising COx data points over a range of blood pressures, the COx data points corresponding to the determined COx;

identify a first cluster of the plurality of clusters that corresponds to an intact autoregulation zone for the patient; and

provide a first output indicative of the intact autoregulation zone for the patient.

2. The system of claim 1 , wherein the processor is configured to identify a second cluster of the plurality of clusters that corresponds to an impaired autoregulation zone for the patient and to provide a second output indicative of the impaired autoregulation zone for the patient.

3. The system of claim 1 , wherein the processor is configured to identify a boundary between the first cluster and a second cluster of the plurality of clusters and to provide a second output indicative of the boundary.

4. The system of claim 1 , wherein the processor is configured to apply the data clustering algorithm in response to determination of a threshold number of COx data points.

5. The system of claim 1 , wherein the data clustering algorithm comprises a k-means clustering algorithm.

6. The system of claim 1 , wherein the data clustering algorithm comprises a Gaussian mixture model.

7. The system of claim 1 , wherein the data clustering algorithm comprises one or more of a density-based spatial clustering of applications with noise (DBSCAN) clustering algorithm, principal component analysis (PCA), independent component analysis (ICA), linear discriminant analysis (LDA), learning vector quantization (LVQ), a self-organizing map (SOM or Kohonen net), or any combination thereof.

8. The system of claim 1 , wherein the processor is configured to:

identify a centroid of the first cluster; and

determine a target blood pressure based on the centroid of the first cluster.

9. The system of claim 1 , further comprising a blood pressure sensor configured to generate the blood pressure signal.

10. A system configured to monitor autoregulation of a patient, the system comprising:

a controller comprising a processor configured to:

receive a regional oxygen saturation signal and a blood pressure signal from one or more medical sensors;

determine a cerebral oximetry index (COx) based on the blood pressure signal and the regional oxygen saturation signal;

determine, using a data clustering algorithm, a plurality of clusters, each cluster of the plurality of clusters comprising COx data points over a range of blood pressures, the COx data points corresponding to the determined COx; and

identify a first cluster of the of the plurality of clusters that corresponds to an intact autoregulation zone for the patient.

11. The system of claim 10 , wherein the processor is configured to:

identify a centroid of the first cluster; and

determine a target blood pressure based on the centroid of the first cluster.

12. The system of claim 10 , wherein the data clustering algorithm comprises one or more of a k-means clustering algorithm, a Gaussian mixture model, a density-based spatial clustering of applications with noise (DBSCAN) clustering algorithm, principal component analysis (PCA), independent component analysis (ICA), linear discriminant analysis (LDA), learning vector quantization (LVQ), a self-organizing map (SOM or Kohonen net), or any combination thereof.

13. The system of claim 10 , wherein the processor is configured to provide an output indicative of the intact autoregulation zone for the patient.

14. A method of monitoring autoregulation, the method comprising:

receiving, by a processor and from one or more medical sensors, a regional oxygen saturation signal indicative of blood oxygen saturation of a patient, and a blood pressure signal indicative of blood pressure of the patient;

determining, by the processor, a cerebral oximetry index (COx) based on the blood pressure signal and the regional oxygen saturation signal;

determining, by the processor, using a data clustering algorithm, a plurality of clusters, each cluster of the plurality of clusters comprising COx data points over a range of blood pressures, the COx data points corresponding to the determined COx; and

identifying, by the processor a first cluster of the plurality of clusters that corresponds to an intact autoregulation zone for the patient.

15. The method of claim 14 , comprising providing, by the processor, an output indicative of the intact autoregulation zone for the patient.

16. The method of claim 14 , comprising identifying, by the processor, a second cluster of the plurality of clusters that corresponds to an impaired autoregulation zone for the patient and providing an output indicative of the impaired autoregulation zone for the patient.

17. The method of claim 14 , wherein identifying the first cluster using the data clustering algorithm comprises identifying the first cluster in response to determining a threshold number of COx data points.

18. The method of claim 14 , wherein the data clustering algorithm comprises one or more of a k-means clustering algorithm, a Gaussian mixture model, a density-based spatial clustering of applications with noise (DBSCAN) clustering algorithm, principal component analysis (PCA), independent component analysis (ICA), linear discriminant analysis (LDA), learning vector quantization (LVQ), a self-organizing map (SOM or Kohonen net), or any combination thereof.

19. The method of claim 14 , comprising:

identifying a centroid of the first cluster; and

determining, by the processor, a target blood pressure based on the centroid of the first cluster.

20. The method of claim 19 , comprising providing, by the processor, an output indicative of the target blood pressure.