Neuroprotection by mitochondria-targeted metformin
View Patent ↗The present invention provides modified metformin compounds, particularly mito-metformin compounds, and pharmaceutical compositions thereof. Methods of using the compounds to provide neuroprotection and in the treatment and/or prevention of neurodegenerative diseases are also described.
1. A method for providing a subject in need thereof with neuroprotection, comprising administering to said subject a neuroprotective composition which includes an effective amount of the mito-metformin compound of the following structure,
wherein n is selected from the group consisting of one (1), five (5), nine (9), and eleven (11).
2. The method of claim 1 , wherein the subject suffers from a neurodegenerative disease.
3. The method of claim 2 , wherein the subject suffers from a neurodegenerative disease selected from the group consisting of Parkinson's disease, Alzheimer's disease and other related neurological diseases.
4. The method of claim 1 , wherein the subject is a mammal.
5. The method of claim 4 , wherein the mammal is a human.
6. The method of claim 1 , wherein the administering to said subject the neuroprotective composition prevents, reduces or reverses neuronal cell death within the subject.
7. The method of claim 1 , wherein the method treats a neural injury in a subject having a neurodegenerative disease by administering an effective amount of the neuroprotection composition in order to treat the neural injury.
8. The method of claim 1 , wherein the neuroprotective composition is administered in an amount effective to prevent, reduce or treat at least one symptom in a subject suffering from a neurodegenerative disease.
9. The method of claim 8 , wherein the neurodegenerative disease is Parkinson's disease or Alzheimer's disease.