Method for treating a tubular anatomical structure
An apparatus and method for treatment of a tubular anatomical structure is disclosed. The method includes using an electrical energy to destroy elongated cells on the tubular anatomical structure. The apparatus may include one or more electrodes for creating an electric field, and a cooling system for carrying heat away from the electrode. The elongated cells can include nerve cells on the tubular anatomical structure.
1. A method for treating nerve cells around a tubular anatomical structure, the method comprising:
advancing into the tubular anatomical structure a catheter having a balloon and at least one electrode;
positioning the advanced electrode near a target area containing at least one nerve cell;
expanding the balloon to place the at least one electrode near the target area;
applying, using the positioned electrode, an electrical treatment signal in an amount sufficient to destroy the at least one nerve cell in the target area; wherein the electrical treatment signal has an amplitude of at least 1000 Volts/cm.
2. The method of claim 1 , wherein the step of applying an electrical treatment signal includes applying a plurality of electrical signals in a direction substantially along the length of the at least one nerve cell.
3. The method of claim 1 , wherein the electrical treatment signal is an amount above an upper limit of electroporation to irreversibly open pores in membranes of the at least one nerve cell, thereby killing the nerve cell.
4. The method of claim 1 , wherein the electrical treatment signal has a duration of at least 10 microseconds.
5. The method of claim 1 , wherein the at least one electrode comprises a plurality of electrodes and wherein the electrical treatment signal includes applying a plurality of rectangular electrical pulses to cause an electric field, wherein the plurality of electrical pulses is distributed among the plurality of electrodes through a switching circuit.
6. The method of claim 1 , further comprising the step of cooling the tubular anatomical structure to a temperature in the range of 10 to 20 degrees Celsius.
7. The method of claim 1 , wherein the step of applying includes applying the electrical current in a direction which is substantially radial to the tubular anatomical structure.
8. The method of claim 1 , further comprising determining an endpoint by monitoring the resistance of the target area.
9. The method of claim 1 , wherein the step of applying includes:
applying the electrical treatment signal in a direction substantially along the length of the at least one nerve cell and in a direction which is substantially radial to the tubular anatomical structure.
10. A method for treating nerve cells around a tubular anatomical structure, the method comprising:
advancing into the tubular anatomical structure a catheter having a balloon and at least one electrode;
positioning the advanced electrode near a target area containing at least one nerve cell;
expanding the balloon to place the at least one electrode near the target area;
preheating, using radio-frequency energy, the target area prior to applying an electrical treatment signal;
applying, using the positioned electrode, an electrical treatment signal in an amount sufficient to destroy the at least one nerve cell in the target area, wherein the electrical treatment signal includes applying a plurality of rectangular electrical pulses to cause an electric field, wherein the plurality of electrical pulses is distributed among the set of electrodes through a switching circuit; and wherein the electrical treatment signal has an amplitude of at least 1000 Volts/cm.
11. The method of claim 10 , wherein the electrical treatment signal is an amount above an upper limit of electroporation to irreversibly open pores in membranes of the at least one nerve cell, thereby killing the nerve cell.
12. The method of claim 10 , wherein the electrical treatment signal has a duration of at least 10 microseconds.
13. The method of claim 10 , further comprising the step of determining an endpoint by monitoring the resistance of the target area.
14. A method for treating nerve cells around a tubular anatomical structure, the method comprising:
advancing into the tubular anatomical structure a catheter having a balloon and at least one electrode;
positioning the advanced electrode near a target area containing at least one nerve cell without piercing the target area;
expanding the balloon to place the at least one electrode near the target area;
applying, using the positioned electrode, an electrical treatment signal in an amount sufficient to destroy the at least one nerve cell in the target area; wherein the electrical treatment signal has an amplitude of at least 1000 Volts/cm; and
determining an endpoint by monitoring the resistance of the target area.
15. The method of claim 14 , wherein the at least one electrode comprises a plurality of electrodes and wherein the electrical treatment signal includes applying a plurality of rectangular electrical pulses to cause an electric field, wherein the plurality of electrical pulses is distributed among the plurality of electrodes through a switching circuit.
16. The method of claim 14 , wherein the electrical treatment signal is an amount above an upper limit of electroporation to irreversibly open pores in membranes of the at least one nerve cell, thereby killing the nerve cell.
17. The method of claim 14 , wherein the electrical treatment signal has a duration of at least 10 microseconds.