IP Library Granted Patent US 9,757,417
Granted Patent B2
US 9,757,417 · App. 15/297,680 · Granted Sep 12, 2017

Bioactive glass preparation and use

Inventors: Himanshu Jain (Bethlehem, PA); Roman Holovchak (Clarksville, TN); Matthias M. Falk (Emmaus, PA)
Assignee: Lehigh Universtiy
A61K33/42A61K33/00A61K33/08A61L27/10A61L27/54C03B19/02C03B32/02C03C3/097C03C4/0007C03C4/0014A61L2430/34C03C2204/00
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Quick Facts
Patent No.
US 9,757,417
App. No.
15/297,680
Granted
Sep 12, 2017
Kind
B2
Abstract

A process of preparing a glass comprising: (a) heating a mixture of precursor chemicals to a melt temperature to form a melt, the melt being characterized in that quenching the melt at or above a threshold temperature results in a spinodal phase separation, and quenching the melt below the threshold temperature results in a droplet phase separation; and (b) quenching the melt at or above the threshold temperature in a preheated mold to form the glass composition having the spinodal phase separation.

Claims (8)

1. A method of using a glass to promote bioactivity, said method comprising:

disposing said glass composition in a cellular environment, said glass having spinodal separation and being essentially free of pores; and

facilitating cellular attachment and proliferation on said glass composition.

2. The method of claim 1 , wherein said cellular attachment and/or proliferation is greater than that on glass having formed from the same mixture but with droplet phase separation or no phase separation.

3. The method of claim 1 , wherein said cellular environment is a body of an animal.

4. The method of claim 3 , wherein said cellular environment is a human body.

5. The method of claim 3 , wherein facilitating cellular attachment comprises maintaining the life of the cells of said animal for an extended period of time.

6. The method of claim 5 , wherein said animal is a human.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jul 22, 2020
From: LEHIGH UNIVERSITY
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 053287/0404 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 19, 2016
From: JAIN, HIMANSHU; HOLOVCHAK, ROMAN; FALK, MATTHIAS M.
To: LEHIGH UNIVERSITY
Reel/Frame 040423/0099 →
Continuity (3)
Continuation 14526319 · Oct 28, 2014
Provisional Application 61896227 · Oct 28, 2013
Related Publication 20170035805A1 · Feb 9, 2017