Systems and methods for reconfigurable point-of-care diagnostics
A reconfigurable point-of-care system, comprising an analysis device having one or more detection components to perform a diagnostic method on a sample, the sample being loaded on a microfluidic chip, wherein the analysis device provides identification information, an interface device coupled to the analysis device to provide a communication channel, and a reader unit coupled to the communication channel and having a processor to select the diagnostic method based on the identification information and reconfigure one or more components of the interface device based on the analysis device.
1. A reconfigurable point-of-care system, comprising:
an analysis device having one or more detection components to perform at least one diagnostic method on a sample, the sample being loaded on a microfluidic chip, wherein the analysis device provides identification information associated with the analysis device;
an interface device coupled to the analysis device to provide at least one communication channel;
a reader unit coupled to the at least one communication channel and having at least one processor to select the at least one diagnostic method based on the identification information and reconfigure one or more components of the interface device based on the analysis device, the interface device being configured to provide secure device handshaking between the reader unit and the analysis device; and
a controller configured for selecting and reconfiguring input output connections coupled to the analysis device based on the identification information such that only appropriate commands are transmitted to or from the analysis device.
2. The system of claim 1 , wherein the one or more detection components is selected from the group consisting of a light source, one or more lenses, one or more beam splitters, one or more filters, a light sensor, and a light-emitting diode.
3. The system of claim 1 , wherein the analysis device includes an excitation controller to apply one or more excitations signals to at least one electrode coupled to a sample interface, the sample interface being coupled to the sample on the microfluidic chip.
4. The system of claim 3 , wherein the excitation controller includes a dielectrophoresis (DEP) signal generator.
5. The system of claim 3 , wherein the analysis device includes a timer to apply the one or more excitations signals at predetermined intervals.
6. The system of claim 1 , wherein the one or more detection components detects one or more electromagnetic signals associated with the sample, the one or more electromagnetic signals including detected measurement data selected from the group consisting of fluorescence measurements emitted by the sample, color measurements emitted by the sample, color measurements absorbed by the sample, impedance measurements, and magnetic measurements.
7. The system of claim 6 , wherein the analysis device includes a calibration unit to classify the detected measurement data into at least one category of concentration values by comparing the detected measurement data with a calibrated model.
8. The system of claim 7 , wherein the reader unit includes a display unit to visually display the detected measurement data.
9. The system of claim 1 , wherein the one or more components of the interface device is selected from the group consisting of a power bus line, a camera bus, digital input/output pins, and analog input/output pins.
10. The system of claim 1 , wherein the at least one diagnostic method includes one or more instructions to perform impedance detection, fluorescence imaging, colorimetric analysis or magnetic variation analysis.
11. A reconfigurable point-of-care system, comprising:
an analysis device having one or more detection components to perform at least one diagnostic method on a sample and a dielectrophoresis (DEP) signal generator to apply one or more excitations signals to at least one electrode coupled to a sample interface, the sample being loaded on a microfluidic chip and the sample interface being coupled to the microfluidic chip, wherein the analysis device provides identification information associated with the analysis device;
an interface device coupled to the analysis device to provide at least one communication channel;
a reader unit coupled to the at least one communication channel and having at least one processor to select the at least one diagnostic method based on the identification information and reconfigure one or more components of the interface device based on the analysis device, the interface device being configured to provide secure device handshaking between the reader unit and the analysis device; and
a controller configured for selecting and reconfiguring input output connections coupled to the analysis device based on the identification information such that only appropriate commands are transmitted to or from the analysis device.
12. The system of claim 11 , wherein the one or more detection components is selected from the group consisting of a light source, one or more lenses, one or more beam splitters, one or more filters, a light sensor, and a light-emitting diode.
13. The system of claim 11 , wherein the analysis device includes a timer to apply the one or more excitations signals at predetermined intervals.
14. The system of claim 11 , wherein the one or more detection components detects one or more measurements associated with the sample, the one or more measurements being selected from the group consisting of fluorescence measurements emitted by the sample, color measurements emitted by the sample, color measurements absorbed by the sample, impedance measurements, and magnetic measurements.
15. The system of claim 11 , wherein the at least one diagnostic method includes one or more instructions to perform impedance detection, fluorescence imaging, colorimetric analysis or magnetic variation analysis.