IP Library › Granted Patent US 10,507,232
Granted Patent B2
US 10,507,232 · App. 15/300,807 · Granted Dec 17, 2019

Materials and methods for the treatment of latent viral infection

Inventors: David C. Bloom (Gainesville, FL); Dane M. Phelan (Gainesville, FL); Bryan R. Cullen (Durham, NC); Matthew E. Kennedy (Chapel Hill, NC)
Assignees: University of Florida Research Foundation, Incorporated; Duke University
A61K38/465A61K31/045A61K31/52A61K31/522A61K31/7072A61K45/06C12N7/00C12N9/22C12Y301/00A61K48/00C07K2319/80C12N2710/16611C12N2710/16661
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Quick Facts
Patent No.
US 10,507,232
App. No.
15/300,807
Granted
Dec 17, 2019
Kind
B2
Abstract

The subject invention pertains to materials and methods for the treatment of latent viral infections.

Claims (3)

1. A method of treating a latent viral infection comprising the administration of a fusion protein comprising a TAL binding domain that binds a target gene of a latent virus and an effector domain to a subject having a latent viral infection, wherein (a) the target gene is selected from ICP27, ICP0, ICP4, UL5, UL7, UL30, LAT and/or UL25, (b) the effector domain is an endonuclease, and (c) the fusion protein modulates the target gene of the latent virus, wherein the viral infection is caused by an HSV-1 or HSV-2 virus.

2. A method of treating a latent viral infection comprising the administration of a vector encoding the fusion protein according to claim 1 to a subject having a latent viral infection.

3. The method of claim 1 , wherein the target gene is ICP4 and the effector domain is Mme1.

Assignments (3)
CONFIRMATORY LICENSE Recorded Feb 13, 2017
From: UNIVERSITY OF FLORIDA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 041690/0247 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2016
From: CULLEN, BRYAN R.; KENNEDY, E. MATTHEW
To: DUKE UNIVERSITY
Reel/Frame 039902/0639 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2016
From: BLOOM, DAVID C.; PHELAN, DANE M.
To: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
Reel/Frame 039902/0649 →
Continuity (2)
Provisional Application 61973995 · Apr 2, 2014
Related Publication 20170020994A1 · Jan 26, 2017