Specific and unique T cell responses and molecular signatures for the treatment and diagnosis of
The invention relates to novel targets for immune response modulation, treatment of tuberculosis infection and epitopes of Mycobacterium tuberculosis , or subsequences, portions or modifications thereof, and methods and compounds for treatment and prevention of tuberculosis infection.
1. A method of modulating an immune response, comprising administration of an effective amount of an antagonist of Th* cell activity, wherein the method comprises modulating expression or activity of IL23R, and wherein the method reduces the immune response.
2. The method of claim 1 , wherein the method treats the cavitation phase of Mycobacterium tuberculosis infection.
3. The method of claim 1 , wherein the method comprise reducing the immune response to treat an aberrant immune response.