Methods and systems for blocking neural activity in an organ of a subject, preferably in the small intestine or the duodenum
The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.
1. A method for reducing neural activity in a duodenum of a subject, the method comprising:
introducing at least one laser emitting device comprising a cooling mechanism into the duodenum;
emitting a laser beam, at an intensity in the range of a 100 mW-10 W, from the laser emitting device to a target area in the duodenum, wherein the laser beam is configured to be absorbed by the different layers of the duodenum in the target area; wherein the laser beam has enough linear optical absorption to elevate tissue temperature at a focal plane of the laser beam to 45° C.-75° C.; and
lowering a temperature of the target area using the cooling mechanism, thereby selectively ablating sensory nerves located in the target area's submucosal layer to at least partially reduce the neural activity within the submucosal layer while maintaining functional activity of the mucosal layer within the treated target area and/or surrounding the target area.
2. The method of claim 1 , wherein the sensory nerves comprise at least one nerve that is activated by food passing through the duodenum; and/or wherein the sensory nerves comprise at least one nerve that transmits signals from at least one of mechano-sensors or chemo-receptors located within the duodenal wall.
3. The method of claim 1 , wherein the laser emitting device comprises a rotatable optical element configured to direct the laser beam to a plurality of target areas along a trajectory on or within the duodenal wall.
4. The method of claim 3 , wherein the rotatable optical element is selected from a group consisting of a wide-angle lens, a dove prism, a reversion or “K” prism, a Delta or Pechan prism, a dispersive prism, a reflective prism, a beam-splitting prism, a deflective prism, a triangular prism, a trapezoidal prism, a Glan-Taylor prism or a Glan-laser prism, a high-powered laser-light right angle prism, a retroreflector and combinations thereof.
5. The method of claim 1 , wherein the cooling mechanism comprises infusion, irrigation or rinsing of tissue surrounding sensory nerves with a coolant material.
6. The method of claim 1 , wherein emitting the laser beam comprises emitting pulsed laser radiation.
7. The method of claim 1 , wherein said subject is afflicted with a medical condition selected from the group consisting of obesity, type 2 diabetes, insulin resistance, metabolic syndrome, and combinations thereof.
8. The method of claim 1 , wherein the cooling mechanism is configured to lower the temperature of target area in the path of the laser beam's energy transfer.
9. The method of claim 1 , wherein the laser beam has a wavelength of 808 nm-980 nm.