IP Library Granted Patent US 10,198,817
Granted Patent B2
US 10,198,817 · App. 15/304,611 · Granted Feb 5, 2019

Technologies for diagnosing neurological or psychiatric illnesses

Inventors: Scott A. Small (Millerton, NY); Frank A. Provenzano (New York, NY); Usman A. Khan (Brooklyn, NY)
Assignee: The Trustees of Columbia University in the City of New York
G06T7/0016G06T5/50G06T7/11G06T7/136G06T5/20G06T2207/10088G06T2207/20224G06T2207/30016G06T2207/30101
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Quick Facts
Patent No.
US 10,198,817
App. No.
15/304,611
Granted
Feb 5, 2019
Kind
B2
Abstract

A technology which enables identifying, via a computer, a vessel in a third image. The third image is obtained from a subtraction of a second image from a first image. The second image and the first image are aligned on an imaging space. The first image is post-contrast. The second image is pre-contrast. The technology enables determining, via the computer, a voxel intensity mean value of a segment of the vessel in the third image. The technology enables obtaining, via the computer, a fourth image from a division of the third image by the voxel intensity mean value. The technology enables applying, via the computer, a filter onto the fourth image. The technology enables generating, via the computer, a filter mask based on the fourth image.

Claims (56)

1. A method comprising:

identifying, via a computer, a vessel in a third image, wherein the third image is obtained from a subtraction of a second image from a first image, wherein the second image and the first image are aligned within an imaging space, wherein the first image is post-contrast, wherein the second image is pre-contrast;

determining, via the computer, a voxel intensity mean value of a segment of the vessel in the third image based on a highest voxel intensity in the segment of the vessel such that the voxel intensity mean value indicates at least one of a content of a blood or a flow of the blood in the segment of the vessel;

obtaining, via the computer, a fourth image from a division of the third image by the voxel intensity mean value such that a percentage of a volume of the blood shown in the segment of the fourth image is determinable;

applying, via the computer, a filter onto the fourth image; and

generating, via the computer, a filter mask based on the fourth image.

2. The method of claim 1 , further comprising:

performing, via the computer, a vessel segmentation process on at least one of the first image or the second image before the identifying.

3. The method of claim 2 , wherein the performing is automatically triggered.

4. The method of claim 1 , wherein the vessel comprises a diameter of about one centimeter or less.

5. The method of claim 1 , wherein the identifying is based on a vesselness filter and a pre-defined region of interest, wherein the vesselness filter filters based on a set of eigenvalues of a Hessian matrix of the third image, wherein the third image is modified such that the region of interest is positioned in a predefined area.

6. The method of claim 1 , wherein the voxel intensity mean value is based on a highest voxel intensity range in the segment, wherein the range comprises a top 40% of voxel intensities.

7. The method of claim 6 , wherein the range comprises a top 33% of voxel intensities.

8. The method of claim 6 , wherein the range comprises a top 25% of voxel intensities.

9. The method of claim 1 , wherein the third image is a cerebral blood volume map, wherein the filter is based on at least one of a performance of an expectation-maximization segmentation, or a fitting of a bimodal Gaussian curve to a histogram of data in accordance with the third image.

10. The method of claim 1 , wherein the filter mask is a binary mask, and further comprising:

applying, via the computer, the binary mask to the third image; and

mapping, via the computer, based on the applying, the third image according to a change in a transverse relaxation time induced via an input of a contrast agent.

11. A system comprising:

a hardware processor;

a memory coupled to the hardware processor, wherein the memory stores a set of instructions to execute via the hardware processor, wherein the instructions instruct the hardware processor to perform a method comprising:

identifying, via a computer, a vessel in a third image, wherein the third image is obtained from a subtraction of a second image from a first image, wherein the second image and the first image are aligned within an imaging space, wherein the first image is post-contrast, wherein the second image is pre-contrast;

determining, via the computer, a voxel intensity mean value of a segment of the vessel in the third image based on a highest voxel intensity in the segment of the vessel such that the voxel intensity mean value indicates at least one of a content of a blood or a flow of the blood in the segment of the vessel;

obtaining, via the computer, a fourth image from a division of the third image by the voxel intensity mean value such that a percentage of a volume of the blood shown in the segment of the fourth image is determinable;

applying, via the computer, a filter onto the fourth image; and

generating, via the computer, a filter mask based on the fourth image.

12. The system of claim 11 , wherein the method further comprises:

performing, via the computer, a vessel segmentation process on at least one of the first image or the second image before the identifying.

13. The system of claim 12 , wherein the performing is automatically triggered.

14. The system of claim 11 , wherein the vessel comprises a diameter of about one centimeter or less.

15. The system of claim 11 , wherein the identifying is based on a vesselness filter and a pre-defined region of interest, wherein the vesselness filter filters based on a set of eigenvalues of a Hessian matrix of the third image, wherein the third image is modified such that the region of interest is positioned in a predefined area.

16. The system of claim 11 , wherein the voxel intensity mean value is based on a highest voxel intensity range in the segment, wherein the range comprises a top 40% of voxel intensities.

17. The system of claim 16 , wherein the range comprises a top 33% of voxel intensities.

18. The system of claim 16 , wherein the range comprises a top 25% of voxel intensities.

19. The system of claim 11 , wherein the third image is a cerebral blood volume map, wherein the filter is based on at least one of a performance of an expectation-maximization segmentation, or a fitting of a bimodal Gaussian curve to a histogram of data in accordance with the third image.

20. The system of claim 11 , wherein the filter mask is a binary mask, and wherein the method further comprises:

applying, via the computer, the binary mask to the third image; and

mapping, via the computer, based on the applying, the third image according to a change in a transverse relaxation time induced via an input of a contrast agent.

21. A non-transitory computer-readable storage device storing a set of instructions for execution via a processing circuit to implement a method, wherein the method comprises:

identifying, via a computer, a vessel in a third image, wherein the third image is obtained from a subtraction of a second image from a first image, wherein the second image and the first image are aligned within an imaging space, wherein the first image is post-contrast, wherein the second image is pre-contrast;

determining, via the computer, a voxel intensity mean value of a segment of the vessel in the third image based on a highest voxel intensity in the segment of the vessel such that the voxel intensity mean value indicates at least one of a content of a blood or a flow of the blood in the segment of the vessel;

obtaining, via the computer, a fourth image from a division of the third image by the voxel intensity mean value such that a percentage of a volume of the blood shown in the segment of the fourth image is determinable;

applying, via the computer, a filter onto the fourth image; and

generating, via the computer, a filter mask based on the fourth image.

22. The computer-readable storage device of claim 21 , wherein the method further comprises:

performing, via the computer, a vessel segmentation process on at least one of the first image or the second image before the identifying.

23. The computer-readable storage device of claim 22 , wherein the performing is automatically triggered.

24. The computer-readable storage device of claim 21 , wherein the vessel comprises a diameter of about one centimeter or less.

25. The computer-readable storage device of claim 21 , wherein the identifying is based on a vesselness filter and a pre-defined region of interest, wherein the vesselness filter filters based on a set of eigenvalues of a Hessian matrix of the third image, wherein the third image is modified such that the region of interest is positioned in a predefined area.

26. The computer-readable storage device of claim 21 , wherein the voxel intensity mean value is based on a highest voxel intensity range in the segment, wherein the range comprises a top 40% of voxel intensities.

27. The computer-readable storage device of claim 26 , wherein the range comprises a top 33% of voxel intensities.

28. The computer-readable storage device of claim 26 , wherein the range comprises a top 25% of voxel intensities.

29. The computer-readable storage device of claim 21 , wherein the third image is a cerebral blood volume map, wherein the filter is based on at least one of a performance of an expectation-maximization segmentation, or a fitting of a bimodal Gaussian curve to a histogram of data in accordance with the third image.

30. The computer-readable storage device of claim 21 , wherein the filter mask is a binary mask, and wherein the method further comprises:

applying, via the computer, the binary mask to the third image; and

mapping, via the computer, based on the applying, the third image according to a change in a transverse relaxation time induced via an input of a contrast agent.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 14, 2018
From: SMALL, SCOTT A.; PROVENZANO, FRANK A.; KHAN, USMAN A.
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 047777/0191 →
CONFIRMATORY LICENSE Recorded Aug 4, 2017
From: COLUMBIA UNIV NEW YORK MORNINGSIDE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 043448/0873 →
Continuity (2)
Provisional Application 61981005 · Apr 17, 2014
Related Publication 20170039714A1 · Feb 9, 2017