Targeted adenoviruses and methods of making, isolating, and using
Described herein is an adenovirus comprising an AB-loop comprising a targeting motif and methods of making and using the adenovirus. The targeting motif of the adenovirus can selectively bind to a tumor cell. The targeting motif of the adenovirus can selectively bind to cell markers and/or cell surface antigens including, for example, CD 133.
1. An adenovirus comprising an AB-loop comprising a targeting motif, wherein the targeting motif:
selectively binds to a tumor cell; and
comprises the amino acid sequence GERSGRW (SEQ ID NO:105).
2. An adenovirus comprising an AB-loop comprising a targeting motif, wherein the targeting motif:
selectively binds to a tumor cell that expresses CD133; and
comprises the amino acid sequence TYMLSRN (SEQ ID NO:106).
3. An adenovirus comprising an AB-loop comprising a targeting motif, wherein the targeting motif:
selectively binds to a tumor cell; and
comprises the amino acid sequence VRLLFYP (SEQ ID NO:107).