IP Library Granted Patent US 10,287,257
Granted Patent B2
US 10,287,257 · App. 15/308,517 · Granted May 14, 2019

Linker molecule for multiplex recognition by atomic force microscopy (AFM)

Inventors: Peiming Zhang (Gilbert, AZ); Stuart Lindsay (Phoenix, AZ); Saikat Manna (Tempe, AZ); Subhadip Senapati (Tempe, AZ)
Assignee: Arizona Board of Regents on behalf of Arizona State University
C07D249/06C07C247/04C07D249/04C07D487/04C07D491/052C07K14/001C12N15/115C12N2310/16C12N2310/3517
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Quick Facts
Patent No.
US 10,287,257
App. No.
15/308,517
Granted
May 14, 2019
Kind
B2
Abstract

Some of the embodiments of the present disclosure relate to a compound of the formula, and methods of preparing and using same.

Claims (22)

1. A compound of the following formula:

wherein:

 is phenyl with a plurality of available attachment points;

each p is independently 0, 1, or 2; and n is 3, 4, 5, 6, 7, 8, or 9

each L is independently a

 wherein * denotes the position that is linked to

 and wherein # denotes the position that is linked to R; wherein each R is independently

 wherein each m is independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24; ** denotes the position that is linked to L;

and ## denotes the position that is linked to T; wherein T is a reactive group.

2. The compound of claim 1 , wherein each m is independently 6, 7, 8, 9, 10, 11, or 12.

3. The compound of claim 1 , wherein each T is independently a reactive group selected from the group consisting of ONH 2 , SH, NH 2 , alkyne, alkene, vinyl sulfone, maleimide, carboxylic acids, aldehyde, ketone, and, N 3 .

4. A compound of the following formula:

wherein:

 is phenyl with a plurality of available attachment points;

each p is independently 0, 1, or 2; and n is 3, 4, 5, 6, 7, 8, or 9

each L is independently a

 wherein * denotes the position that is linked to

 and wherein # denotes the position that is linked to R;

each R is independently

 wherein each m is independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, or 24; ** denotes the position that is linked to L; and ## denotes the position that is linked to T; and

wherein each T is N 3 .

5. A compound, wherein the compound is

Assignments (3)
CONFIRMATORY LICENSE Recorded Jan 22, 2019
From: ARIZONA STATE UNIVERSITY TEMPE CAMPUS
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 048103/0820 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 11, 2018
From: MANNA, SAIKAT; SENAPATI, SUBHADIP; ZHANG, PEIMING
To: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Reel/Frame 045783/0303 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 10, 2017
From: LINDSAY, STUART
To: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Reel/Frame 043822/0356 →
Continuity (2)
Provisional Application 61989874 · May 7, 2014
Related Publication 20170137389A1 · May 18, 2017