Compounds and nail polish
Compositions, methods, and kits that deliver a compound, such as 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, through a keratin substrate are presented.
1. A method of inhibiting the growth of a fungus, or killing a fungus, or both, and said fungus is located inside of a mammalian nail, or on the dorsal side of a mammalian nail, or on the proximal side of a mammalian nail, or on the nail bed,
comprising:
a) applying a nail polish to the mammalian nail, thus forming a coated nail;
b) applying to the coated nail, a pharmaceutical formulation comprising a pharmaceutically acceptable excipient and a compound, wherein the compound is 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole or a pharmaceutically acceptable salt, solvate, or hydrate thereof
thereby inhibiting the growth of a fungus, or killing a fungus, or both.
2. The method of claim 1 , wherein the fungus is selected from the group consisting of Candida species, Trichophyton species, Microsporium species, Aspergillus species, Cryptococcus species, Blastomyces species, Cocciodiodes species, Histoplasma species, Paracoccidioides species, Phycomycetes species, Malassezia species, Fusarium species, Epidermophyton species, Scytalidium species, Scopulariopsis species, Alternaria species, Penicillium species, Phialophora species, Rhizopus species, Scedosporium species and Zygomycetes class.
3. The method of claim 1 , wherein said fungus is a dermatophyte.
4. The method of claim 1 , wherein said fungus is selected from the group consisting of Trichophyton species, Microsporum species, and Epidermophyton species.
5. The method of claim 1 , wherein said fungus is a yeast-like fungus.
6. The method of claim 1 , wherein said fungus is Trichophyton rubrum.
7. The method of claim 1 , wherein said fungus is Trichophyton mentagrophytes.
8. The method of claim 1 , wherein at the beginning of the applying a) the nail polish does not contain the compound.
9. The method of claim 1 , wherein the nail polish of the applying a) is applied to the dorsal side of the mammalian nail.