IP Library Granted Patent US 10,105,377
Granted Patent B2
US 10,105,377 · App. 15/309,408 · Granted Oct 23, 2018

Compounds and nail polish

Inventors: Dina Coronado (Santa Clara, CA); Tejal Merchant (Cupertino, CA)
Assignee: Pfizer Inc.
A61K31/69A61K8/731A61K9/0014A61Q3/02A61K2800/884
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Quick Facts
Patent No.
US 10,105,377
App. No.
15/309,408
Granted
Oct 23, 2018
Kind
B2
Abstract

Compositions, methods, and kits that deliver a compound, such as 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, through a keratin substrate are presented.

Claims (13)

1. A method of inhibiting the growth of a fungus, or killing a fungus, or both, and said fungus is located inside of a mammalian nail, or on the dorsal side of a mammalian nail, or on the proximal side of a mammalian nail, or on the nail bed,

comprising:

a) applying a nail polish to the mammalian nail, thus forming a coated nail;

b) applying to the coated nail, a pharmaceutical formulation comprising a pharmaceutically acceptable excipient and a compound, wherein the compound is 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole or a pharmaceutically acceptable salt, solvate, or hydrate thereof

thereby inhibiting the growth of a fungus, or killing a fungus, or both.

2. The method of claim 1 , wherein the fungus is selected from the group consisting of Candida species, Trichophyton species, Microsporium species, Aspergillus species, Cryptococcus species, Blastomyces species, Cocciodiodes species, Histoplasma species, Paracoccidioides species, Phycomycetes species, Malassezia species, Fusarium species, Epidermophyton species, Scytalidium species, Scopulariopsis species, Alternaria species, Penicillium species, Phialophora species, Rhizopus species, Scedosporium species and Zygomycetes class.

3. The method of claim 1 , wherein said fungus is a dermatophyte.

4. The method of claim 1 , wherein said fungus is selected from the group consisting of Trichophyton species, Microsporum species, and Epidermophyton species.

5. The method of claim 1 , wherein said fungus is a yeast-like fungus.

6. The method of claim 1 , wherein said fungus is Trichophyton rubrum.

7. The method of claim 1 , wherein said fungus is Trichophyton mentagrophytes.

8. The method of claim 1 , wherein at the beginning of the applying a) the nail polish does not contain the compound.

9. The method of claim 1 , wherein the nail polish of the applying a) is applied to the dorsal side of the mammalian nail.

Assignments (2)
CHANGE OF NAME Recorded Jan 11, 2024
From: ANACOR PHARMACEUTICALS, INC.
To: ANACOR PHARMACEUTICALS, LLC
Reel/Frame 066286/0058 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 7, 2016
From: CORONADO, DINA; MERCHANT, TEJAL
To: ANACOR PHARMACEUTICALS, INC.
Reel/Frame 040245/0527 →
Continuity (2)
Provisional Application 61988897 · May 5, 2014
Related Publication 20170216327A1 · Aug 3, 2017