Medicament for accelerated wound healing
A medicament for accelerated wound healing is proposed containing derivatives of the formula (I), in which R 1 stands for hydrogen or methyl.
1. A method for acceleration of wound healing, by applying a cell regenerating effective amount of a drug consisting essentially of a derivative of the formula (I)
in which R 1 denotes methyl, to activate the olfactory receptor OR2AT4.
2. The method for acceleration of wound healing of claim 1 , comprising using an effective amount of the drug according to claim 1 to stimulate the proliferation and migration of cells.
3. The method for acceleration of wound healing of claim 1 , comprising using an effective amount of the drug according to claim 1 to stimulate the phosphorylation of MAP kinases.
4. The method for acceleration of wound healing of claim 1 , comprising using an effective amount of the drug according to claim 1 to stimulate the expression and secretion of interleukin IL-1α.
5. A method for acceleration of healing a wound that results from the opening of tissue from the epidermis, resulting in a need for tissue closure via tissue regeneration by applying to the wound that results from the opening of tissue, a cell regenerating effective amount of a drug consisting essentially of a derivative of formula (I)
in which R 1 denotes hydrogen or methyl, effective to accelerate tissue regeneration at the wound site, and wherein the drug activates the olafactory receptor OR2AT4, increases the proliferation and migration of HaCaT cells and regenerates cells at the wound site at a rate increased by the application of the drug to the wound.
6. The method of claim 5 , wherein R 1 is methyl.
7. The method of claim 5 , wherein R 1 is H.