Alkyl and aryl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
1. A compound of Formula I
wherein
Z is —C(O)—;
m is 1;
n is 1, 2 or 3;
R 1 is substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkylaryl, substituted or unsubstituted alkylheterocyclyl or —(CH2) r -W—R 1′ ;
r is 0, 1 or 2;
W is —CH 2 O—, —CH 2 C(O)NR 5′ —, —CH 2 C(O)O—, —CH 2 C(O)— or —C(CH 3 ) 2 O—;
R 1′ is H, —CN, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl or R 5 ;
wherein the aryl, heterocyclyl or cycloalkyl in R 1 or R 1′ if substituted, also in alkylaryl or alkylheterocyclyl, are substituted with substituents selected from the group consisting of —R 5 , —OR 5 , halogen, —NO 2 , —NR 5 R 5′″ , —C(O)OR 5 , NR 5 C(O)R 5′ , —C(O)NR 5 R 5′ , —NR 5 S(O) 2 R 5′ , ═O, —OCH 2 CH 2 OH, —NR 5 C(O)NR 5′ R 5″ , —S(O) 2 NR 5 R 5′ , —NR 5 S(O) 2 NR 5′ R 5″ , haloalkyl, haloalkoxy, —SR 5 , and —S(O)R 5 ;
and wherein “aryl” is a monocyclic aryl and “heterocyclyl” is a heterocyclic ring system of one or two saturated or unsaturated rings of which at least one ring contains one or more heteroatoms from the group consisting of nitrogen, oxygen and/or sulfur in the ring;
X is a bond, —C(O)O—, —C(O)NR 5 —, —C(O)—, —O— or —C(R 4 R 4′ )—;
R 2 is H, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl or substituted or unsubstituted C 2-6 alkynyl,
wherein the aryl, heterocyclyl or cycloalkyl in R 2 , if substituted, also in alkylaryl, alkylcycloalkyl or alkylheterocyclyl, is substituted with substituents selected from the group consisting of —R 5 , —OR 5 , halogen, —CN, —NO 2 , —NR 5 R 5′″ , —C(O)OR 5 , —NR 5 C(O)R 5′ , —C(O)NR 5 R 5′ , —NR 5 S(O) 2 R 5′ , ═O, —OCH 2 CH 2 OH, —NR 5 C(O)NR 5′ R 5″ , —S(O) 2 NR 5 R 5′ , —NR 5 S(O) 2 NR 5′ R 5″ , haloalkyl, -haloalkoxy, —SR 5 , —S(O)R 5 or —S(O) 2 R 5 ;
and wherein “aryl” is a monocyclic aryl and “heterocyclyl” is a heterocyclic ring system of one or two saturated or unsaturated rings of which at least one ring contains one or more heteroatoms from the group consisting of nitrogen, oxygen and/or sulfur in the ring;
R 3 and R 3′ are independently selected from the group consisting of H, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkylaryl, substituted or unsubstituted alkylheterocyclyl, and substituted or unsubstituted alkylcycloalkyl;
wherein the aryl, cycloalkyl and heterocyclyl as defined in R 3 , also in alkylaryl, alkylcycloalkyl or alkylheterocyclyl, if substituted, are substituted with substituents selected from the group consisting of —OR 5 , halogen, —CN, haloalkyl, haloalkoxy, —SR 5 , —S(O)R 5 or —S(O) 2 R 5 ;
and wherein “aryl” is a monocyclic aryl and “heterocyclyl” is a heterocyclic ring system of one or two saturated or unsaturated rings of which at least one ring contains one or more heteroatoms from the group consisting of nitrogen, oxygen and/or sulfur in the ring;
R 4 is H, —OR 5 , substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, —COOR 5 , —CONR 5 R 5′ , —NR 5 COR 5′ , —NR 5 R 5′″ or substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl,
wherein the aryl, cycloalkyl and heterocyclyl as defined in R 4 , if substituted, are substituted with substituents selected from the group consisting of —OR 5 , halogen, —CN, haloalkyl, haloalkoxy, —SR 5 , —S(O)R 5 and —S(O) 2 R 5 ;
and wherein “aryl” is a monocyclic aryl and “heterocyclyl” is a heterocyclic ring system of one or two saturated or unsaturated rings of which at least one ring contains one or more heteroatoms from the group consisting of nitrogen, oxygen and/or sulfur in the ring;
R 4 is H, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl or substituted or unsubstituted C 2-6 alkynyl;
R 5 , R 5′ and R 5″ are independently selected from the group consisting of H, unsubstituted C 1-6 alkyl, unsubstituted C 2-6 alkenyl, unsubstituted C 2-6 alkynyl, unsubstituted aryl or unsubstituted alkylaryl;
wherein “aryl” is a monocyclic aryl;
R 5′″ is H, unsubstituted C 1-6 alkyl, unsubstituted C 2-6 alkenyl, unsubstituted C 2-6 alkynyl or -Boc;
R 8 and R 8′ are independently selected from the group consisting of H, —OR 5 , halogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl or substituted or unsubstituted C 2-6 alkynyl;
wherein
the alkyl, alkenyl and alkynyl as defined in R 1 , R 1′ , R 2 , R 3 , R 3′ , R 4 , R 4′ , R 8 , and R 8′ , if substituted, are substituted with substituents selected from the group consisting of —OR 5 , halogen, —CN, haloalkyl, haloalkoxy, —SR 5 , —S(O)R 5 , —S(O) 2 R 5 , C(O)OR 5 and C(O)NR 5 R 5′ ;
optionally as a stereoisomer, including enantiomers and diastereomers, a racemate or in form of a mixture of at least two of stereoisomers, including enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof,
with the proviso that the following compounds are excluded from formula I:
2. The compound according to claim 1 , wherein R 1 is —(CH2) r -W—R 1′ or R 1 is substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkylaryl, or substituted or unsubstituted alkylheterocyclyl.
3. The compound according to claim 1 , wherein X is a bond; —C(R 4 R 4′ )—; —C(O)O—; —C(O)NR 5 —; —C(O)—; or —O—.
4. The compound according to claim 1 , wherein
m is 1 and
n is 2.
5. The compound according to claim 1 , wherein
R 1 is substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkylaryl, substituted or unsubstituted alkylheterocyclyl, or —(CH2) r -W—R 1′ , wherein
the aryl is phenyl;
and
the alkyl is C 1-6 alkyl.
6. The compound according to claim 5 , wherein R 1 is substituted or unsubstituted phenyl; substituted or unsubstituted pyridine, pyrazine, indazole, benzodioxane, thiazole, benzothiazole, morpholine, tetrahydropyran, pyrazole, or imidazole; substituted or unsubstituted benzyl; or substituted or unsubstituted alkylheterocyclyl, wherein the heterocyclyl is pyridine, pyrazine, indazole, benzodioxane, thiazole, benzothiazole, morpholine, tetrahydropyrane, pyrazole, or imidazole and the alkyl is methyl.
7. The compound according to claim 1 , wherein
R 1′ is H, —CN, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl or R 5 ; wherein
the aryl is phenyl:
the heterocyclyl is a heterocyclic ring system of one or more saturated or unsaturated rings of which at least one ring contains one or more heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur;
and
the cycloalkyl is C 3-8 cycloalkyl.
8. The compound according to claim 7 , wherein R 1′ is substituted or unsubstituted phenyl; substituted or unsubstituted morpholine or tetrahydropyran; or substituted or unsubstituted cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.
9. The compound according to claim 1 , wherein
R 2 is H, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl or substituted or unsubstituted C 2-6 alkynyl; wherein
the aryl is phenyl;
and
the cycloalkyl is Cm cycloalkyl.
10. The compound according to claim 9 , wherein R 2 is substituted or unsubstituted phenyl; substituted or unsubstituted pyridine, piperidine, thiazole, morpholine, tetrahydropyran, pyrazole, thiophene, indole, benzimidazole, pyrrolo[2,3b]pyridine, benzoxazole, oxopyrrolidine, or pyrimidine; substituted or unsubstituted cyclopropyl; substituted or unsubstituted methyl or isopropyl; substituted or unsubstituted ethenyl, propenyl, butenyl, pentenyl, or hexenyl; or substituted or unsubstituted ethynyl, propynyl, butynyl, pentynyl, or hexynyl.
11. The compound according to claim 1 , wherein
R 3 and R 3′ are independently selected from the group consisting of H, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkylaryl, substituted or unsubstituted alkylheterocyclyl, and substituted or unsubstituted alkylcycloalkyl, wherein
the alkyl is C 1-6 alkyl;
the cycloalkyl is C 3-8 cycloalkyl; and
the aryl is phenyl.
12. The compound according to claim 11 , wherein the C 1-6 alkyl is methyl or ethyl; the C 2-6 alkenyl is ethenyl, propenyl, butenyl, pentenyl, or hexenyl; the C 2-6 alkynyl is ethynyl, propynyl, butynyl, pentynyl, or hexynyl; the cycloalkyl is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl; the aryl is phenyl; and the heterocyclyl is imidazole, oxadiazole, tetrazole, pyridine, pyrimidine, piperidine, piperazine, benzofuran, benzimidazole, indazole, benzothiazole, benzodiazole, thiazole, benzothiazole, tetrahydropyran, morpholine, indoline, furan, triazole, isoxazole, pyrazole, thiophene, benzothiophene, pyrrole, pyrazine, pyrrolo[2,3b]pyridine, quinoline, isoquinoline, phthalazine, benzo-1,2,5-thiadiazole, indole, benzotriazole, benzoxazole, oxopyrrolidine, pyrimidine, benzodioxolane, benzodioxane, or quinazoline.
13. The compound according to claim 1 , wherein
R 4 is H, —OR 5 , substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, —COOR 5 , —CONR 5 R 5′ , —NR 5 COR 5′ , —NR5R5′″, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl,
and
R 4′ is H or substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl or substituted or unsubstituted C 2-6 alkynyl), wherein
the cycloalkyl is C 3-8 cycloalkyl; and
the aryl is phenyl.
14. The compound according to claim 13 , wherein the C 1-6 alkyl is methyl; the C 2-6 alkenyl is ethenyl, propenyl, butenyl, pentenyl, or hexenyl; the C 2-6 alkynyl is ethynyl, propynyl, butynyl, pentynyl, or hexynyl; the heterocyclyl is tetrahydropyran; the aryl is phenyl; and the cycloalkyl is cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl.
15. The compound according to claim 1 , wherein
R 5 , R 5′ and R 5″ are independently H, unsubstituted C 1-6 alkyl, unsubstituted C 2-6 alkenyl, unsubstituted C 2-6 alkynyl, unsubstituted aryl or unsubstituted alkylaryl;
R 5′″ is H, unsubstituted C 1-6 alkyl, unsubstituted C 2-6 alkenyl, unsubstituted C 2-6 alkynyl or -Boc, wherein
the alkyl is C 1-6 alkyl;
and
the aryl is phenyl.
16. The compound according to claim 15 , wherein the C 1-6 alkyl is methyl, ethyl, or isopropyl; the C 2-6 alkenyl is ethenyl, propenyl, butenyl, pentenyl, or hexenyl; the C 2-6 alkynyl is ethynyl, propynyl, butynyl, pentynyl, or hexynyl; and the aryl is phenyl.
17. The compound according to claim 1 , wherein
R 8 and R 8′ are independently selected from the group consisting of H, —OR 5 , halogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl or substituted or unsubstituted C 2-6 alkynyl.
18. The compound according to claim 17 , wherein R 8 and R 8′ are independently selected from the group consisting of substituted or unsubstituted methyl, ethyl, propyl, butyl, pentyl, hexyl, isopropyl, or 2-methylpropyl; substituted or unsubstituted ethenyl, propenyl, butenyl, pentenyl, or hexenyl; or substituted or unsubstituted ethynyl, propynyl, butynyl, pentynyl, or hexynyl.
19. The compound according to claim 1 , which is selected from the group consisting of:
4-(4-methoxyphenyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-benzyl-4-(2-methoxyphenyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-benzyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-methoxyphenyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-benzyl-4-(3-methoxyphenyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-benzyl-9-phenyl-6-oxa-2,9-diazaspiro[4.5]decan-8-one
4-(3-methoxyphenyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
(R)-2-methyl-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
(S)-2-methyl-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-(methoxymethyl)-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
(S)-2-(methoxymethyl)-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
(R)-2-(methoxymethyl)-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-ethyl-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
methyl 2-(3-oxo-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-2-yl)acetate
4-(3-methoxyphenyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-benzyl-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-isopropyl-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2,2-dimethyl-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-(benzyloxymethyl)-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-(1-methyl-1H-pyrazol-3-yl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-(2-(5-nitropyridin-2-yl)ethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-methyl-9-(2-(5-nitropyridin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-methyl-9-(2-(3-nitropyridin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(pyrimidin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-(2-(2-nitropyridin-3-yl)ethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(4-(trifluoromethyl)pyridin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(6-aminopyridin-2-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(4-aminopyridin-2-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-methyl-9-(2-(6-(trifluoromethyl)pyridin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(2-aminopyridin-4-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(3-(trifluoromethyl)pyridin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(5-(trifluoromethyl)pyridin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(4-methoxypyridin-2-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
6-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)nicotinonitrile
9-(2-(3-chloropyridin-2-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(5-chloropyridin-2-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-isopropyl-9-(2-(2-nitropyridin-3-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(2-(trifluoromethyl)pyridin-4-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)isonicotinonitrile
9-(2-(6-aminopyridin-2-yl)ethyl)-2-methyl-4-(4-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-(2-(2-nitropyridin-3-yl)ethyl)-4-(4-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(3-chloropyridin-2-yl)ethyl)-2-methyl-4-(4-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(3-chloropyridin-2-yl)ethyl)-2-methyl-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(3-chloropyridin-2-yl)ethyl)-4-((5-fluoropyridin-2-yl)methyl)-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(3-fluoropyridin-2-yl)ethyl)-4-((5-fluoropyridin-2-yl)methyl)-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(3-fluoropyridin-2-yl)ethyl)-2-methyl-4-(2-(trifluormethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-((5-fluoropyridin-2-yl)methyl)-2-methyl-9-(2-(6-(trifluoromethyl)pyridin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(3-chloropyridin-4-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-fluorophenethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(4-methoxyphenethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(thiophen-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(3-fluorophenethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(4-fluorophenethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(1H-pyrazol-1-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-methoxyphenethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(pyridin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-((tetrahydro-2H-pyran-4-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(3-phenylpropyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-(2-(4-methylthiazol-5-yl)ethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(1H-indol-1-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(1H-benzo[d]imidazol-1-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
methyl 3-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)propanoate
2-methyl-9-(2-morpholinoethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-(4-nitrophenethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-(3-nitrophenethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-(2-nitrophenethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
methyl 4-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)benzoate
2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)-N-phenylacetamide
2-methyl-9-(2-phenoxyethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(pyridin-3-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)benzo[d]oxazol-2(3H)-one
3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5,5]undecan-9-yl)ethyl)benzonitrile
4-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)benzonitrile
9-(2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-(2-morpholino-2-oxoethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecen-3-one
9-(2-methoxyphenethyl)-4-(pyridin-2-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-9-isopentyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(cyclopropylmethyl)-4-(2-fluorophenyl)-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-9-(3-methoxyphenethyl)-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(pyridin-2-yl)ethyl)-4-(pyridin-2-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-phenethyl-4-(pyridin-2-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(thiazol-4-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-9-(2-(6-fluoropyridin-2-yl)ethyl)-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-methyl-9-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
N-methyl-3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)benzenesulfonamide
9-(2-(5-fluoropyridin-2-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(thiazol-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(3-fluoropyridin-2-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(pyridin-2-yl)ethyl)-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-oxo-2-phenylethyl)-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
N-methyl-3-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)-N-phenylpropanamide
2-methyl-9-(2-(pyridin-2-yl)ethyl)-4-(4-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(6-methoxypyridin-2-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(3-nitrophenethyl)-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-((6-aminopyridin-2-yl)methy)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-((5-chloropyridin-2-yl)methyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
tert-butyl (4-(2-(3-oxo-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)thiazol-2-yl)carbamate
N-methyl-4-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)benzenesulfonamide
4-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)benzenesulfonamide
2-methyl-9-(2-(3-nitro-1H-pyrazol-1-yl)ethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(6-methoxypyridin-3-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(5-(trifluoromethyl)pyridin-3-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(6-chloropyridin-3-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(5-fluoropyridin-3-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(5-chloropyridin-3-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
tert-butyl (1-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)-1H-pyrazol-5-yl)carbamate
tert-butyl (4-(2-(4-(2-fluorophenyl)-2-isopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)thiazol-2-yl)carbamate
tert-butyl (4-(2-(13-oxo-12-{[5-(trifluoromethyl)pyridin-2-yl]methyl}-4-oxa-8,12-diazadispiro[2.1.5.3]tridecan-8-yl)ethyl)thiazol-2-yl)carbamate
tert-butyl (4-(2-(2-methyl-3-oxo-4-(4-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)thiazol-2-yl)carbamate
9-(2-isopropoxyethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
6-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)picolinonitrile
2-methyl-9-(2-morpholino-2-oxoethyl)-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-isopropoxyethyl)-2-methyl-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-fluorophenethyl)-2-methyl-4-(4-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
(S)-9-(2-fluorophenethyl)-2-methyl-4-(4-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride
(R)-9-(2-fluorophenethyl)-2-methyl-4-(4-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride
2-methyl-9-(2-oxo-2-(piperidin-1-yl)ethyl)-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-(2-oxo-2-(piperidin-1-yl)ethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-fluorophenethyl)-2-methyl-4-(2-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(tetrahydro-2H-pyran-4-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(3-methoxyphenethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-phenyl-9-(2-(pyridin-4-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-(methoxymethyl)-9-(2-(pyridin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-(methoxymethyl)-9-(2-methoxyphenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-fluorophenethyl)-4-(2-fluorophenyl)-2-(methoxymethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-isopropyl-9-(2-methoxyphenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
tert-butyl (4-(2-(4-(2-fluorophenyl)-2-methyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)thiazol-2-yl)carbamate
ethyl 3-(2-(4-(2-fluorophenyl)-2-methyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)benzoate
3-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)-N-phenylpropanamide
2-methyl-4-phenyl-9-(2-(pyridin-3-yloxy)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-(2-(2-oxopyrrolidin-1-yl)ethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(1H-pyrazol-4-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-phenethyl-9-phenyl-6-oxa-2,9-diazaspiro[4.5]decan-8-one
9-(2-hydroxy-2-phenylethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
(R)-9-((R)-2-hydroxy-2-phenylethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
(R)-9-((S)-2-hydroxy-2-phenylethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
(S)-9-((S)-2-hydroxy-2-phenylethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
(S)-9-((R)-2-hydroxy-2-phenylethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-benzyl-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-benzyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorobenzyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(3-fluorobenzyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4,9-diphenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(pyridin-2-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(4-fluorobenzyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(pyridin-3-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(thiazol-2-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(thiazol-5-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(pyridin-4-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-((tetrahydro-2H-pyran-4-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(thiazol-4-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-phenethyl-4-(pyridin-4-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(3-methoxybenzyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-phenethyl-4-(thiazol-4-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-((1-benzyl-1H-imidazol-2-yl)methyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-phenethyl-4-(2-(pyridin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-(2-morpholino-2-oxoethyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-((1-methyl-1H-pyrazol-3-yl)methyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-((1-methyl-1H-imidazol-2-yl)methyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-((3-fluoropyridin-2-yl)methyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-((6-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(2-(pyridin-3-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-((5-fluoropyridin-2-yl)methyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-phenethyl-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-phenethyl-4-(2-(pyridin-4-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(3-nitrobenzyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-hydroxy-2-methylpropyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-benzyl-4-(4-fluorophenyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(4-fluorophenyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(3-fluorophenyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-chlorophenyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(pyrazin-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(pyridin-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
ethyl 3-(2-methyl-3-oxo-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)benzoate
2-methyl-4-(3-nitrophenyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-(1-methyl-1H-indazol-3-yl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-(1-methyl-1H-indazol-6-yl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(benzo[d][1,3]dioxol-5-yl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(benzo[d]thiazol-6-yl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(benzo[d]thiazol-2-yl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(pyridin-4-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-methoxyphenyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(6-(trifluoromethyl)pyridin-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(3-fluoropyridin-2-yl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(thiazol-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-4-(1-methyl-1H-pyrazol-4-yl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(6-methoxypyridin-2-yl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(6-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluoropyridin-3-yl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(4-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(2-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(5-fluoropyridin-3-yl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(5-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-methyl-9-phenethyl-4-(3-(trifluoromethyl)pyridin-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-fluorophenethyl)-2-methyl-4-(3-(trifluoromethyl)pyridin-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
(R)-9-(2-fluorophenethyl)-2-methyl-4-(3-(trifluoromethyl)pyridin-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride
(S)-9-(2-fluorophenethyl)-2-methyl-4-(3-(trifluoromethyl)pyridin-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride
9-(3-aminophenethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(3-aminophenyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(4-aminophenethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-aminophenethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(5-aminopyridin-2-yl)ethyl)-4-(2-fluorophenyl)-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(3-aminopyridin-2-yl)ethyl)-4-(2-fluorophenyl)-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(3-aminobenzyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(2-aminopyridin-3-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(3-aminophenethyl)-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(5-aminopyridin-2-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(3-amino-1H-pyrazol-1-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(2-aminopyridin-3-yl)ethyl)-4-(2-fluorophenyl)-2-isopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(2-aminopyridin-3-yl)ethyl)-2-methyl-4-(4-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
N-(4-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)acetamide
N-(3-(2-methyl-3-oxo-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)phenyl)acetamide
N-(3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)acetamide
(S)—N-(3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)acetamide
(R)—N-(3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)acetamide
N-(2-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)acetamide
N-(3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)isobutyramide
1,1-dimethyl-3-(3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)urea
N-(3-((3-oxo-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methyl)phenyl)acetamide
N-(2-(2-(4-(2-fluorophenyl)-2-methyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)pyridin-3-yl)acetamide
N-(3-(2-(3-oxo-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)acetamide
N-(6-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)pyridin-3-yl)acetamide
N-(2-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)pyridin-4-yl)acetamide
N-(6-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)pyridin-2-yl)acetamide
N-(4-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)pyridin-2-yl)acetamide
N-(3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)methanesulfonamide
N-(2-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)methanesulfonamide
N-(4-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)methanesulfonamide
N-(3-((3-oxo-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methyl)phenyl)methanesulfonamide
N-(3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)propane-2-sulfonamide
1-(3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenyl)urea
1-(6-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)pyridin-2-yl)urea
N-[3-(2-{2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl}ethyl)phenyl]aminosulfonamide
3-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)benzamide
4-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)benzoic acid
3-(2-methyl-3-oxo-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)benzoic acid
3-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)propanoic acid
2-(3-oxo-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-2-yl)acetic acid
N, N-dimethyl-3-(2-methyl-3-oxo-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)benzamide
N, N-dimethyl-2-(3-oxo-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-2-yl)acetamide
N, N-dimethyl-4-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)benzamide
N-methyl-4-(2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)benzamide
3-(2-(4-(2-fluorophenyl)-2-methyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)-N-methylbenzamide
9-(2-hydroxy-2-phenylethyl)-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(6-aminopyridin-3-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-9-(2-(2-hydroxyethoxy)phenethyl)-2-isopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-9-(3-(2-hydroxyethoxy)phenethyl)-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
2-(hydroxymethyl)-9-phenethyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-((1H-imidazol-2-yl)methyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-benzyl-4-(2-hydroxyphenyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-hydroxyphenyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-benzyl-4-(3-hydroxyphenyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(3-hydroxyphenyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-hydroxyphenethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(4-hydroxyphenethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(3-hydroxyphenethyl)-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(4-hydroxyphenyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(3-hydroxyphenyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-hydroxyphenethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-hydroxyphenyl)-2-methyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-9-(2-hydroxyphenethyl)-2-isopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-9-(3-hydroxyphenethyl)-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-hydroxyphenethyl)-4-(pyridin-2-ylmethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-(hydroxymethyl)-9-(2-hydroxyphenethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-(3-hydroxypropyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(2-aminothiazol-4-yl)ethyl)-4-(2-fluorophenyl)-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(2-aminothiazol-4-yl)ethyl)-4-((5-(trifluoromethyl)pyridin-2-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(5-amino-1H-pyrazol-1-yl)ethyl)-2-methyl-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(2-aminothiazol-4-yl)ethyl)-4-(2-fluorophenyl)-2-isopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
9-(2-(2-aminothiazol-4-yl)ethyl)-2-methyl-4-(4-(trifluoromethyl)pyridin-3-yl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-9-phenethyl-2-((tetrahydro-2H-pyran-4-yl)methyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-isopropyl-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-isopropyl-9-(2-(pyridin-2-yl)ethyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
4-(2-fluorophenyl)-2-(3-methoxypropyl)-9-phenethyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
N-methyl-2-(2-methyl-3-oxo-4-phenyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)-N-phenylacetamide
(R)-2-benzyl-9-phenyl-6-oxa-2,9-diazaspiro[4.5]decan-8-one
(S)-2-benzyl-9-phenyl-6-oxa-2,9-diazaspiro[4.5]decan-8-one;
optionally as a stereoisomer, including enantiomers and diastereomers, a racemate or in form of a mixture of at least two stereoisomers, including enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof.
20. A process for the preparation of a compound of formula Ia
wherein
Z is —C(O)—;
m is 1;
n is 1, 2 or 3;
R 1 is substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkylaryl, substituted or unsubstituted alkylheterocyclyl or —(CH 2 ) r —W—R 1′ ;
r is 0, 1 or 2;
W is —CH 2 O—, —CH 2 C(O)NR 5′ —, —CH 2 C(O)O—, —CH 2 C(O)— or —C(CH 3 ) 2 O—;
R 1′ is H, —CN, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl or R 5 ;
wherein the aryl, heterocyclyl or cycloalkyl in R 1 or R 1′ , if substituted, also in alkylaryl or alkylheterocyclyl, are substituted with substituents selected from the group consisting of —R 5 , —OR 5 , halogen, —CN, —NO 2 , —NR 5 R 5′″ , —C(O)OR 8 , NR 5 C(O)R 5′ , —C(O)NR 5 R 5′ , —NR 5 S(O) 2 R 5 , ═O, —OCH 2 CH 2 OH, —NR 5 C(O)NR 5′ R 5′″ , —S(O) 2 NR 5 R 5′ , —NR 5 S(O) 2 NR 5 R 5″ , haloalkyl, haloalkoxy, —SR 5 , —S(O)R 5 and —S(O) 2 R 5 ;
and wherein “aryl” is a monocyclic aryl and “heterocyclyl” is a heterocyclic ring system of one or two saturated or unsaturated rings of which at least one ring contains one or more heteroatoms from the group consisting of nitrogen, oxygen and/or sulfur in the ring;
X is a bond, —C(O)O—, —C(O)NR 5 —, —C(O)—, —O— or —C(R 4 R 4′ )—;
R 2 is H, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl or substituted or unsubstituted C 2-6 alkynyl;
wherein the aryl, heterocyclyl or cycloalkyl in R 2 , if substituted, also in alkylaryl, alkylcycloalkyl or alkylheterocyclyl, is substituted with substituents selected from the group consisting of —R, —OR 5 , halogen, —CN, —NO 2 , —NR 5 R 5′″ , —C(O)OR 5 , —NR 5 C(O)R 5′ , —C(O)NR 5 R 5′ , —NR 5 S(O) 2 R 5′ , ═O, —OCH 2 CH 2 OH, —NR 5 C(O)NR 5 R 5″ , —S(O) 2 NR 5 R 5′ , —NR 5 S(O) 2 NR 5′ R 5″ , haloalkyl, -haloalkoxy, —SR 5 , —S(O)R 5 and —S(O) 2 R 5 ;
and wherein “aryl” is a monocyclic aryl and “heterocyclyl” is a heterocyclic ring system of one or two saturated or unsaturated rings of which at least one ring contains one or more heteroatoms from the group consisting of nitrogen, oxygen and/or sulfur in the ring;
R 3 and R 3′ are independently selected from the group consisting of H, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkylaryl, substituted or unsubstituted alkylheterocyclyl, and substituted or unsubstituted alkylcycloalkyl; wherein the aryl, cycloalkyl and heterocyclyl as defined in R 3 , also in alkylaryl, alkylcycloalkyl or alkylheterocyclyl, if substituted, are substituted with substituents selected from the group consisting of —OR 5 , halogen, —CN, haloalkyl, haloalkoxy, —SR 5 , —S(O)R 5 and —S(O) 2 R 5 ;
and wherein “aryl” is a monocyclic aryl and “heterocyclyl” is a heterocyclic ring system of one or two saturated or unsaturated rings of which at least one ring contains one or more heteroatoms from the group consisting of nitrogen, oxygen and/or sulfur in the ring;
R 4 is H, —OR 5 , substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl, substituted or unsubstituted C 2-6 alkynyl, —COOR 5 , —CONR 5 R 5′ , —NR 5 COR 5′ , —NR 5 R 5′″ or substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted cycloalkyl,
wherein the aryl, cycloalkyl and heterocyclyl as defined in R 4 , if substituted, are substituted with substituents selected from the group consisting of —OR 5 , halogen, —CN, haloalkyl, haloalkoxy, —SR 5 , —S(O)R 5 and —S(O) 2 R 5 ;
and wherein “aryl” is a monocyclic aryl and “heterocyclyl” is a heterocyclic ring system of one or two saturated or unsaturated rings of which at least one ring contains one or more heteroatoms from the group consisting of nitrogen, oxygen and/or sulfur in the ring;
R 4′ is H, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl or substituted or unsubstituted C 2-6 alkynyl;
R 5 , R 5′ , and R 5″ are independently selected from the group consisting of H, unsubstituted C 1-6 alkyl, unsubstituted C 2-6 alkenyl, unsubstituted C 2-6 alkynyl, and unsubstituted aryl and unsubstituted alkylaryl;
and wherein “aryl” is a monocyclic aryl;
R 5′″ is H, unsubstituted C 1-6 alkyl, unsubstituted C 2-6 alkenyl, unsubstituted C 2-6 alkynyl or -Boc;
R 8 and R 8′ are independently selected from the group consisting of H, —OR 5 , halogen, substituted or unsubstituted C 1-6 alkyl, substituted or unsubstituted C 2-6 alkenyl and substituted or unsubstituted C 2-6 alkynyl;
wherein
the alkyl, alkenyl and alkynyl as defined in R 1 , R 1′ , R 2 , R 3 , R 3′ , R 4 , R 4′ , R 8 , and R 8′ , if substituted, are substituted with substituents selected from the group consisting of —OR 5 , halogen, —CN, haloalkyl, haloalkoxy, —SR 5 , —S(O)R 5 , —S(O) 2 R 5 , C(O)OR 5 and C(O)NR 5 R 5′ ;
with the proviso that the the following compounds are excluded from formula Ia:
which comprises the steps
(a) reacting a compound of formula Va
with a compound of formula VI
wherein LG is a leaving group,
to obtain a compound of formula VIIa
and
(b) Carrying out a cyclisation of the resulting compound in a suitable solvent, in the presence of a strong base and at a temperature comprised between −78° C. and the reflux temperature.
21. A pharmaceutical composition which comprises the compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
22. 3-(2-methyl-3-oxo-9-phenethyl-11-oxa-4,9-diazaspiro[5.5]undecan-4-yl)benzonitrile, optionally as a stereoisomer, including enantiomers and diastereomers, a racemate or in form of a mixture of at least two stereoisomers, including enantiomers and/or diastereomers, in any mixing ratio, or a corresponding salt thereof.