IP Library › Granted Patent US 10,626,137
Granted Patent B2
US 10,626,137 · App. 15/314,792 · Granted Apr 21, 2020

Minimal saponin analogues, synthesis and use thereof

Inventors: David Y. Gin (New York City, NY); Eric K. Chea (New York City, NY); Alberto Fernandez-Tejada (New York City, NY); Derek S. Tan (New York City, NY); Jason S. Lewis (New York City, NY); Jeffrey R. Gardner (New York City, NY); NagaVaraKishore Pillarsetty (Jackson Heights, NY)
Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER
C07H15/256A61K31/704A61K31/7024A61K39/39A61K45/06C07H15/18C07H15/24A61K2039/55577
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Quick Facts
Patent No.
US 10,626,137
App. No.
15/314,792
Granted
Apr 21, 2020
Kind
B2
Abstract

Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.

Claims (6)

1. A compound having the formula:

2. A pharmaceutical composition, comprising: the compound of claim 1 , or a pharmaceutically acceptable salt thereof; and an immunologically effective amount of an antigen.

3. A method for immunizing a subject against an infectious disease, comprising: administering to the subject the pharmaceutical composition of claim 2 .

4. A pharmaceutical composition, comprising: the compound of claim 1 , or a pharmaceutically acceptable salt thereof; and an effective amount of a cytotoxic drug.

5. A method for enhancing the effect of a cytotoxic drug in a subject, comprising:

administering to the subject the pharmaceutical composition of claim 4 .

Assignments (1)
CONFIRMATORY LICENSE Recorded Dec 14, 2016
From: SLOAN-KETTERING INST CAN RESEARCH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 040934/0483 →
Continuity (2)
Provisional Application 62005302 · May 30, 2014
Related Publication 20170096444A1 · Apr 6, 2017
Cited By (1)
US 12,187,755