Composition for enhancing memory and learning function and/or cognitive function
Compositions, foods, and medicaments for enhancing memory and learning function and/or cognitive function are provided. Compositions, foods, and medicaments for improving brain function and particularly enhancing memory and learning function and/or cognitive function can be provided by including a peptide including an amino acid sequence set forth in any one of SEQ ID NOs 1 to 16 as an active ingredient.
1. A method of enhancing memory and learning function or cognitive function, or enhancing memory and learning function and cognitive function, comprising administering a composition comprising a peptide that comprises the amino acid sequence of SEQ ID NO: 13, or a pharmaceutically acceptable salt or solvate thereof, to a subject in need such enhancement.
2. The method according to claim 1 , wherein said peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 4, 7, 8 and 11.
3. The method according to claim 1 , wherein the composition is in the form of a food.
4. The method according to claim 1 , wherein the composition is in the form of a medicament.
5. The method according to claim 1 , wherein the peptide is produced by hydrolysis of a protein contained in a food or food material.
6. The method according to claim 1 , wherein the peptide is obtained by an enzymatic treatment of a milk protein, or of a food or food material containing the milk protein, with an enzymatic agent from a microorganism.
7. The method according to claim 6 , wherein the milk protein or the food or food material containing the milk protein is whey or casein.
8. The method according to claim 6 , wherein the enzymatic agent comprises at least one enzyme from a microbe, wherein said at least one enzyme is from a microbe of a genus selected from the group consisting of Aspergillus, Bacillus and Rhizopus.
9. A method of enhancing microglial phagocytotic activity or anti-inflammatory activity, or enhancing microglial phagocytotic activity and anti-inflammatory activity, comprising administering a composition comprising a peptide that comprises the amino acid sequence of SEQ ID NO: 13, or a pharmaceutically acceptable salt or solvate thereof, to a subject in need such enhancement.
10. The method according to claim 9 , wherein said peptide consists of the amino acid sequence of SEQ ID NO: 13.
11. The method according to claim 1 , wherein said peptide consists of an amino acid sequence selected from the group consisting of SEQ ID NOs: 4, 7, 8, 11 and 13.
12. The method according to claim 9 , wherein the composition is in the form of a food.
13. The method according to claim 9 , wherein the composition is in the form of a medicament.
14. The method according to claim 9 , wherein the peptide is produced by hydrolysis of a protein contained in a food or food material.
15. The method according to claim 9 , wherein the peptide is obtained by an enzymatic treatment of a milk protein, or a food or food material containing the milk protein, with an enzymatic agent from a microorganism.
16. The method according to claim 15 , wherein the milk protein or the food or food material containing the milk protein is whey or casein.
17. The method according to claim 15 , wherein the enzymatic agent comprises at least one enzyme from a microbe, wherein said at least one enzyme is from a microbe of a genus selected from the group consisting of Aspergillus, Bacillus and Rhizopus.