VETERINARY METHODS FOR USING NITRIC OXIDE IN A PLASMA STATE TO TREAT MEDICAL CONDITIONS AND DISEASES IN ANIMALS
Veterinary methods for administering nitric oxide (NO) in a plasma state to a treatment site associated with an animal are disclosed. A discrete stream of matter is placed in a plasma state, in which the stream has, as part of its content, a desired concentration of NO. The discrete stream of matter is directed at a site of action associated with an animal to achieve a therapeutic result. A method for decontamination of veterinary equipment with NO in a plasma state is also disclosed.
1 . A veterinary method for administering nitric oxide in a plasma state to an animal, the method comprising:
creating a discrete stream of matter that has been put into a state of plasma, in which the stream has, as part of its content, nitric oxide (NO) in a concentration from about 5 ppm to 3500 ppm; and
directing the discrete stream of matter at a site of action associated with an animal to obtain a therapeutic result by at least one of stimulating sub-dermal production of NO, mobilization of NO in a plasma state across and through the dermis, and the direct effect of NO in a plasma state on pathogens.
2 . The method of claim 1 , wherein directing the discrete stream of matter at a site of action comprises positioning a device used to create the discrete stream of matter from 1 to 50 centimeters from the device to the site.
3 . The method of claim 1 , wherein directing the discrete stream of matter at a site of action comprises directing the discrete stream of matter for 1 to 120 seconds for each square centimeter of site area.
4 . The method of claim 1 , wherein the discrete stream of matter is directed to the site over a plurality of discrete application procedures, wherein the plurality of discrete application procedures is from 1 to 200 discrete applications.
5 . The method of claim 1 , further comprising directing the discrete stream of matter to the site over multiple discrete time periods, the time periods separated by from 3 to 168 hours.
6 . The method of claim 1 , wherein the temperature of the stream at contact with the site is from 10 to 60 degrees C.
7 . The method of claim 1 , wherein the velocity of the stream at contact with the site is from 0.05 to 200 meters per second.
8 . The method of claim 1 , wherein the stream of nitric oxide plasma is created using an electric arc discharge device.
9 . The method of claim 1 , wherein the stream of nitric oxide plasma is created using a microwave discharge device.
10 . The method of claim 1 , wherein the stream of nitric oxide plasma is created using a gliding arc discharge device.
11 . The method of claim 1 , wherein the therapeutic result is selected from the list consisting of facilitating vasodilation, alleviating pain associated with osteoarthritis and Rheumatoid Arthritis, combating Gram Positive microorganisms, combating Gram Negative microorganisms, combating fungi and viruses.
12 . The method of claim 1 , wherein the therapeutic result is selected from the list consisting of treating osteoporosis, collagen formation, stem cell signaling, satellite cell differentiation, wound healing, wound management, acne, nerve regeneration, inhibiting cancer cell proliferation, promoting apoptosis, stimulating endogenous nitric oxide production, and stimulating iNOS pathways.
13 . The method of claim 1 , wherein the therapeutic result is selected from the list consisting of maintaining homeostasis in the cardiovascular and respiratory systems, causing vasodilation, easing blood pressure, cleaning the blood, reversing atherosclerosis, preventing cardiovascular diseases, slowing down atherosclerotic plaque deposition on vascular walls, suppressing bacterial infections, suppressing viruses and parasitic attacks, deterring cancer cell growth, reducing pain associated with joint swelling in arthritis, decreasing the risk of cancer, diabetes, myocardial infarction and stroke.
14 . The method of claim 1 , wherein the therapeutic result is selected from the list consisting of facilitating hair-growth, reducing wrinkles, facilitating vasodilation, alleviating pain associated with osteoarthritis and Rheumatoid Arthritis, combating Gram Positive microorganisms, combating Gram Negative microorganisms, combating fungi and viruses.
15 . The method of claim 1 , wherein directing the discrete stream of matter at a site of action is undertaken according to the following criteria:
Minimum
Maximum
Parameter
Value
Value
Distance from exit to site (cm)
1
50
Time of Application (sec/cm 2 )
5
45
Number of treatments
1
10
Length of time between treatments (hours)
3
168
Temperature of plasma stream at contact with
10
60
Site ° C.
Velocity of Plasma Stream at contact with Site
0.05
200
(m/sec)
16 . The method of claim 1 , wherein directing the discrete stream of matter at a site of action is undertaken according to the following criteria:
Minimum
Maximum
Parameter
Value
Value
Distance from exit to site (cm)
1
25
Time of Application (sec/cm 2 )
15
120
Number of treatments
3
50
Length of time between treatments (hours)
12
168
Temperature of plasma stream at contact with
10
60
Site ° C.
Velocity of Plasma Stream at contact with Site
0.05
200
(m/sec)
17 . The method of claim 1 , wherein directing the discrete stream of matter at a site of action is undertaken according to the following criteria:
Minimum
Maximum
Parameter
Value
Value
Distance from exit to site (cm)
1
45
Time of Application (sec/cm 2 )
1
45
Number of treatments
1
200
Length of time between treatments (hours)
3
168
Temperature of plasma stream at contact with
10
60
Site ° C.
Velocity of Plasma Stream at contact with Site
0.05
200
(m/sec)
18 . The method of claim 1 , wherein directing the discrete stream of matter at a site of action is undertaken according to the following criteria:
Minimum
Maximum
Parameter
Value
Value
Distance from exit to site (cm)
1
45
Time of Application (sec/cm 2 )
10
90
Number of treatments
1
24
Length of time between treatments (hours)
3
168
Temperature of plasma stream at contact with
10
60
Site ° C.
Velocity of Plasma Stream at contact with Site
0.05
200
(m/sec)
19 . The method of claim 1 , wherein directing the discrete stream of matter at a site of action is undertaken according to the following criteria:
Minimum
Maximum
Parameter
Value
Value
Distance from exit to site (cm)
1
45
Time of Application (sec/cm 2 )
5
45
Number of treatments
1
24
Length of time between treatments (hours)
3
168
Temperature of plasma stream at contact with
10
60
Site ° C.
Velocity of Plasma Stream at contact with Site
0.05
200
(m/sec)
20 . The method of claim 1 , wherein directing the discrete stream of matter at a site of action is undertaken according to the following criteria:
Minimum
Maximum
Parameter
Value
Value
Distance from exit to site (cm)
1
50
Time of Application (sec/cm 2 )
5
90
Number of treatments
1
60
Length of time between treatments (hours)
3
168
Temperature of plasma stream at contact with
10
60
Site ° C.
Velocity of Plasma Stream at contact with Site
0.05
200
(m/sec)
21 . The method of claim 1 , wherein the therapeutic result includes infection prevention associated with open wounds, bites, punctures, pre-surgical sites, post-surgical sites, castration, docking, ear cropping, foot trimming or microchip installation.
22 . The method of claim 1 , wherein the therapeutic result includes infection prevention associated with emerging diseases involving bacterial surface infections, fungal surface infections, gum line infections, hoof bacterial infections, infectious foot rot, infection due to disbudding and dehorning, mastitis, skin infections, allergies, skin irritations, strangles related conditions, toenail infections and tusk trimming infections.
23 . The method of claim 1 , wherein the therapeutic result includes alleviation of at least one of trauma, wounds and inflammation associated with arthritis, polyarthritis, edema, joint edema, lameness, muscle inflammation, muscle injury, soft tissue trauma, bruise or contusion.
24 . The method of claim 1 , wherein the therapeutic result comprises combating at least one pathogen selected from the list consisting of Bacillus Necrophorus, Bacteroides melaninogenicus, Bacteroides nodosus, Bacteroides fragilis, Bacteroides splanchnicus, Clostridium septicum, C. chauvoei, C. novyi, C. perfringens, C. septicum, C. sordellii, C. tetani, Campylobacter jejuni, Demodex, Escherichia coli , Follivulitis, Fusobacterium necrophorum, Fusobacterium necrophorum , Gingivitis, Impetigo, Lactobacilus planttarum , Onychomycosis, Paronychia, Peptostreptococcus, Peridontitis, Porphyromonas denticanis, Porphyromonas gulae, Porphyromonas salivosa, Prevotella intermedia, Salmonella enterica Sarcoptes, Staphylococcus aureus, Staphylococcus hyicus, Staphylococcus spp and Streptococcus spp, Streptococcus agalactiae, Streptococcus equi, Streptococcus pyogenes, Tinea Corporsis , and Treponema spp.
25 . A method for disinfecting veterinary equipment using nitric oxide in a plasma state, the method comprising:
creating a discrete stream of matter that has been put into a state of plasma, in which the stream has, as part of its content, nitric oxide (NO) in a concentration from about 5 ppm to 3500 ppm; and
directing the discrete stream of matter at a surface to disinfect the surface.
26 . The method of claim 25 , wherein the surface is selected from the list consisting of a clothing surface, a shoe surface, and a veterinary equipment surface.