Fluoroquinolones and use thereof to treat bacterial infections

1. A compound of general Formula I:

and pharmaceutically acceptable salts thereof, wherein:

R 1 represents a saturated or unsaturated, substituted or unsubstituted, branched or unbranched alkyl group comprising 4 to 20 carbons atoms, when the alkyl group is substituted, the substituent is selected in the group comprising halo, hydroxyl, nitro, amido, carboxy, amino, cyano, alkoxy, haloalkoxy, or haloalkyl,

R 2 represents a substituent selected from the group comprising hydrogen, alkyl, alkene, alkyne, cycloalkyl, aryl, halo, hydroxyl, oxo, nitro, amido, carboxy, amino, cyano, alkoxy, haloalkoxy, or haloalkyl,

R 3 , R 4 , R 5 and R 6 may be identical or different and each represents a substituent selected from hydrogen, alkyl, alkene, alkyne, cycloalkyl, aryl, halo, hydroxyl, oxo, nitro, amido, carboxy, amino, cyano, alkoxy, haloalkoxy, or haloalkyl,

R 7 represents a substituent selected from hydrogen, alkyl, alkene, alkyne, cycloalkyl, aryl, halo, hydroxyl, oxo, nitro, amido, carboxy, amino, cyano, alkoxy, haloalkoxy, or haloalkyl,

with the condition that the compounds of formula I are not:

7-(4-butylpiperazin-l-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-7-(4-heptylpiperazin-l-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

7-(4-butyl-3-methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-7-(4-hexyl-3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-7-(4-(4-hydroxybuty)piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

with the condition that when R 2 is a hydrogen and R 7 is a fluorine, R 3 , R 4 , R 5 and R 6 are not a methyl group.

2. The compound according to claim 1 , wherein R 1 represents a saturated or unsaturated, substituted or unsubstituted, branched or unbranched alkyl group comprising 5 to 16 carbons atoms.

3. The compound according to claim 1 , wherein R 2 represents a substituent selected from the group comprising hydrogen, methyl, methoxy, ethoxy, chloro and fluoro.

4. The compound according to claim 1 , wherein R 3 , R 4 , R 5 and R 6 are identical and represent each a hydrogen.

5. The compound according to claim 1 , wherein R 7 representsa hydrogen, NH 2 or fluoro.

6. The compound according to claim 1 , having the general formula II corresponding to the general formula I wherein R 7 is a fluorine:

and pharmaceutically acceptable salts thereof.

7. The compound according to claim 1 , having the general formula III corresponding to compounds of general formula II wherein R 3 , R 4 , R 5 and R 6 are identical and represent a hydrogen atom:

and pharmaceutically acceptable salts thereof.

8. The compound according to claim 1 , selected from the group comprising:

1-cyclopropyl-6-fluoro-4-oxo-7-(4-pentylpiperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-7-(4-hexylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-7-(4-octylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-7-(4-nonylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-7-(4-decylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-4-oxo-7-(4-undecylpiperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-7-(4-dodecylpiperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-4-oxo-7-(4-tridecylpiperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-4-oxo-7-(4-tetradecylpiperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-4-oxo-7-(4-pentadecylpiperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-7-(4-hexadecylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(4-pentylpiperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-7-(4-hexylpiperazin-1-yl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-7-(4-heptylpiperazin-1-yl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-8-methoxy-7-(4-octylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-8-methoxy-7-(4-nonylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-7-(4-decylpiperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(4-undecylpiperazin-1- yl)-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-7-(4-dodecylpiperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(4-tridecylpiperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(4-tetradecylpiperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-(4-pentadecylpiperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid,

1-cyclopropyl-6-fluoro-7-(4-hexadecylpiperazin-1-yl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid,

and pharmaceutically acceptable salts thereof.

9. A pharmaceutical composition comprising at least one compound according to claim 1 , or a pharmaceutically acceptable salt, and at least one pharmaceutically acceptable carrier, diluent, excipient and /or adjuvant.

10. The pharmaceutical composition according to claim 9 , further comprising a therapeutic agent and/or active ingredient.

11. A medicament comprising a compound according to claim 1 .

12. The medicament according to claim 11 , further comprising a therapeutic agent and/or active ingredient.