IP Library Granted Patent US 10,761,000
Granted Patent B2
US 10,761,000 · App. 15/320,769 · Granted Sep 1, 2020

Liquid stirring method

Inventors: Shunsuke Sasaki (Tokyo, JP); Yoshihiro Yamashita (Tokyo, JP)
Assignee: HITACHI HIGH-TECH CORPORATION
G01N1/38B01F3/08B01F3/0861B01F11/0074B01F13/00B01F15/02G01N35/02G01N35/1009B01F2215/0037
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Quick Facts
Patent No.
US 10,761,000
App. No.
15/320,769
Granted
Sep 1, 2020
Kind
B2
Abstract

In a liquid stirring method, after a second liquid is discharged into a reaction container accommodating a first liquid from a dispensing probe provided with a dispensing tip at the leading end thereof, a mixture of the first liquid and second liquid in the container is stirred by being sucked out and discharged by the dispensing probe. The number of stirrings through sucking out and discharging is changed according to the total volume of the first liquid and second liquid. If the total volume of the first liquid and second liquid is below a preset threshold, sucking out and discharging is repeated for a prescribed number of times.

Claims (23)

1. A stirring method to stir a mixed liquid comprised of a first liquid and a second liquid in a first container by driving a syringe, the method comprising:

determining, by a control device, whether a total liquid volume of the mixed liquid is greater than a prescribed threshold;

in a case where the total liquid volume of the mixed liquid is greater than the prescribed threshold, performing a first stirring process only once by the control device controlling driving of the syringe, the first stirring process including sucking out the mixed liquid from the first container by controlling driving of the syringe to a first syringe drive amount and discharging the mixed liquid from the syringe into the mixed liquid remaining in the first container by controlling driving of the syringe to a second syringe drive amount, that is greater than the first syringe drive amount; and

in a case where the total liquid volume of the mixed liquid is equal to or less than the prescribed threshold, repeatedly performing a second stirring process for a predetermined number of times by the control device controlling driving of the syringe, the second stirring process including sucking out the mixed liquid from the first container by controlling driving of the syringe to a third syringe drive amount and discharging the mixed liquid from the syringe into the mixed liquid remaining in the first container by controlling driving of the syringe to a fourth syringe drive amount, that is greater than the third syringe drive amount and smaller than the first syringe drive amount,

wherein, in the first stirring process, the mixed liquid sucked out from the first container is smaller than the total liquid amount of the mixed liquid, and

wherein, in the second stirring process, the mixed liquid sucked out from the first container is smaller than the total liquid amount of the mixed liquid.

2. The stirring method according to claim 1 ,

wherein the threshold is 80 μL.

3. The stirring method according to claim 1 ,

wherein the first liquid is a diluted liquid or a reagent and the second liquid is a test body.

4. The stirring method according to claim 1 ,

wherein the second stirring process is performed in a time for performing the first stirring process.

5. An automatic analyzing apparatus comprising:

a container configured to hold a mixed liquid comprised of a first liquid and a second liquid;

a probe and a syringe which are connected by a pipe and are configured to suck and discharge the mixed liquid within the container by driving the syringe; and

a control device programmed to:

determine whether a total liquid volume of the mixed liquid is greater than a prescribed threshold;

in a case where the total liquid volume of the mixed liquid is greater than the prescribed threshold, control the probe and syringe to perform a first stirring process only once by controlling driving of the syringe, the first stirring process including sucking out the mixed liquid from the first container by controlling driving of the syringe to a first syringe drive amount and discharging the mixed liquid from the syringe into the mixed liquid remaining in the first container by controlling driving of the syringe to a second syringe drive amount, that is greater than the first syringe drive amount; and

in a case where the total liquid volume of the mixed liquid is equal to or less than the prescribed threshold, control the probe and syringe to repeatedly perform a second stirring process for a predetermined number of times by controlling driving of the syringe, the second stirring process including sucking out the mixed liquid from the first container by controlling driving of the syringe to a third syringe drive amount and discharging the mixed liquid from the syringe into the mixed liquid remaining in the first container by controlling driving of the to a fourth syringe drive amount, that is greater than the third syringe drive amount and smaller than the first syringe drive amount,

wherein, in the first stirring process, the mixed liquid sucked out from the first container is smaller than the total liquid volume of the mixed liquid, and

wherein, in the second stirring process, the mixed liquid sucked out from the first container is smaller than the total liquid volume of the mixed liquid.

6. The automatic analyzing apparatus according to claim 5 ,

wherein the threshold is 80 μL.

Assignments (2)
CHANGE OF NAME AND ADDRESS Recorded Mar 30, 2020
From: HITACHI HIGH-TECHNOLOGIES CORPORATION
To: HITACHI HIGH-TECH CORPORATION
Reel/Frame 052259/0227 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 21, 2016
From: SASAKI, SHUNSUKE; YAMASHITA, YOSHIHIRO
To: HITACHI HIGH-TECHNOLOGIES CORPORATION
Reel/Frame 041085/0902 →